Parasite infestations might have a good side. Wild mice from a Nottinghamshire forest have given experts at The University of Nottingham clues as to the importance of some parasites, such as lice, for the conditioning of a “natural” immune system.
Jan Bradley, Professor of Parasitology, said: “Our understanding of mammalian immunology is largely based on rodents reared under highly unnatural pathogen and stress-free conditions. Analysing the immune response in wild populations can give crucial insights into how the immune system functions in its natural context.”
Many health problems in modern humans are caused by over-active immune responses. The immune system should be able to tell the difference between foreign invaders and its own body cells. But sometimes it can mistake self proteins for non self proteins triggering an attack on its own body and causing an autoimmune disease such as arthritis, asthma, diabetes or multiple sclerosis. Or the body can mistake a harmless substance as a threat causing an allergic response.
The authors say some parasites may exert a moderating effect on the function of a key component of the immune system, which could help reduce overall immune reactivity and the risk of developing immune dysfunctions.
Their research, published in the open access journal BMC Biology, links the louse Polyplax serrata to a strong dampening of certain immune responses in wild wood mice. This implies that other mammals, such as modern humans, that develop in artificial environments may have less regulated, overactive immune systems precisely because they are not exposed to parasites throughout their lives.
The researchers speculate that the louse is able to exert some kind of immuno-suppressive effect, possibly directly by secreting some substance into the mice from its saliva, or indirectly by transmitting bacteria or other pathogens.
Professor Bradley said: “Much like laboratory mice, people in developed countries are currently exposed to a very different profile of infections to that encountered by their ancestors. It is possible that the immune dysfunctions we see today are the result of immune systems moulded by evolution for a set of challenges completely different to those encountered in modern times.”
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Notes to editors
: The University of Nottingham is ranked in the UK's Top 10 and the World's Top 100 universities by the Shanghai Jiao Tong (SJTU) and Times Higher (THE) World University Rankings.
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The University provides innovative and top quality teaching, undertakes world-changing research, and attracts talented staff and students from 150 nations. Described by The Times as Britain's “only truly global university”, it has invested continuously in award-winning campuses in the United Kingdom, China and Malaysia. Twice since 2003 its research and teaching academics have won Nobel Prizes. The University has won the Queen's Award for Enterprise in both 2006 (International Trade) and 2007 (Innovation — School of Pharmacy), and was named ‘Entrepreneurial University of the Year’ at the Times Higher Education Awards 2008.
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