RLO: Volume of Distribution

Please answer the following five questions. When you've completed the quiz, click the Close Window button at the bottom to return to the RLO.

A high degree of plasma protein binding can result in restricted drug distribution.
1. TRUE
2. FALSE
Very lipid soluble drugs can be readily distributed into tissues.
1. TRUE
2. FALSE
A drug with a large volume of distribution which has been taken in overdose can be readily removed by dialysis. (Remember: dialysis only removes free drug from the plasma.)
1. TRUE
2. FALSE
Calculated loading dose is primarily dependent upon volume of distribution and desired concentration.
1. TRUE
2. FALSE
Dose = Vd * desired concentration. What is the dose of gentamicin required to obtain a peak level of 20 mg/L in a 60 kg patient? (The Vd for gentamicin is 0.25 L/kg.)
1. 5 mg
2. 15 mg
3. 300 mg
4. 500 mg