Click on the 'Start Sequence' button to show this animation (5 second intervals).

Infection occurs – infectious cell releases toxins/mediators

White cell
responds
(monocyte)

Reaction initiates cytokines,
tumour necrosis factor and interleukins

More mediators released by TNF
and interleukins which affect the endothelial
lining – increasing capillary permeability

Tissue factor produced – produces prothrombin
which induces thrombin

Thrombin helps produce
clots in micro-vasculature

Platelets activated
– to address
endothelium injury

Fibrinolysis

Microvascular
coagulopathy