Opportunities are available for DM/PhD studentships and Research Fellowships within the research area of Anaesthesia and Intensive Care. The applicants and fellows are encouraged to discuss plans of their research with Prof Mahajan, Dr Hardman and/or Dr Moppett.
We we welcome new research ideas and help the candidates to develop these into viable projects. The candidates must familiarise themselves with our ongoing research themes, as there are many opportunities for them to participate in any of these.
Our principal research interests relate to vascular reactivity, computer simulation of physiological function, the septic patient, and muscle function in critically ill patients. We have ongoing research programme in the area of patient safety and quality improvement. A number of areas are being addressed including safety culture, medication errors, systems approach and consensus methodology.
Studies of vascular reactivity have included investigation of the effects of anaesthetic agents on cerebral blood flow and laboratory investigations into the effects of substances present in the serum of septic patients on contractility of isolated coronary arteries. A programme of investigation into the potential for a safe and effective cerebral vasodilator to treat patients with cerebrovascular spasm will start shortly.
Very complex computer simulations have been developed to study the lung and the cerebral circulation. These simulations can be used to study extreme conditions which could not be investigated in man. They are also able to avoid the need for animal experimentation.
Recent studies have centred on changes in muscle in critically ill patients, including genetic predisposition to myopathy in critical illness.
Much of our research is conducted in collaboration with other schools within the university.
Research project themes could include:
- Patient safety
- Health services research and patient outcomes
- Hip fracture
- Neurovascular effects of anaesthesia
- Endothelial function and Circulation
- Muscle dysfunction
- Quantifying pulmonary disease states in critical illness
- Computational modelling of pulmonary intervention in critical care
- Computational modelling of clinical scenarios of anaesthesia
- Computational pharmacokinetic investigations
- Goal directed therapy in high-risk patients
- Ultrasound in regional anaesthesia
- Peri-operative risk and outcome
Please see further details on our self-funded vacancies page (filter by "anaesthesia").