School of Pharmacy

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Alice Brookes

Postgraduate Research Student,

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Biography

Alice obtained her MChem Chemistry with a Year in Industry from the University of Leicester in 2018, completing her one year industrial placement at RSSL (Reading Scientific Services Ltd.). During her placement, Alice conducted HPLC analysis to quantify vitamins, proteins and sweeteners, and worked on a project to develop a new quantitative RP-HPLC method to be validated. During her master's year, Alice worked in the Biotechnology Group, under the supervision of Dr Elena Piletska. The project involved using molecularly imported monomers (MIPs) to compare cell surface proteins between cell lines resistant to and non-resistant to DLBCL (diffuse large B-cell lymphoma) treatments, ibrutinib and tirabrutinib.

Alice joined the CDT in Advanced Therapeutics and Nanomedicines in 2018 and undertook two research training projects. The first was under the supervision of Dr Maria Marlow, Dr Mischa Zelzer and Dr Lisa White, where she worked on evaluating the viability of cells within hydrogels. The second project was conducted at Upperton Pharma Solutions, and involved stabilising proteins for spray drying via the addition of excipients.

Teaching Summary

During her time at the University of Nottingham, Alice has led undergraduate teaching laboratories in both the Pharmacy and Chemistry departments. She has also been involved in outreach opportunities… read more

Research Summary

PhD Title: Combining Advanced in vivo and ex vivo Imaging to Understand and to Optimize Biodistribution and Site-Specific Targeting of Drugs.

Supervisors: Dr Pavel Gershkovich, Dr Tracey Bradshaw, Professor Morgan Alexander and Dr David Scurr.

Alice's PhD project focuses on the use of cannabinoids and syntehtic derivatives to treat glioblastoma multiforme. This involves the synthesis of cannabinoid derivatives, the in vitro assessment of molecules, including the anti-cancer activtity and investigating the mechanisms of action by 3D OrbiSIMS. This work also investigates the in vivo delivery of cannabinoids to the brain after oral administration, determining the anatomical regions with high CBD delivery by HPLC-UV analysis and ex vivo 3D OrbiSIMS.

During her PhD, Alice has shared her work both internally and externally, most recently with an oral presentation and poster at the UKICRS (UK and Ireland Controlled Reslease Society) symposium in October 2021.

During her time at the University of Nottingham, Alice has led undergraduate teaching laboratories in both the Pharmacy and Chemistry departments. She has also been involved in outreach opportunities which involve teaching students from primary school through to sixth form on various pharmacy and chemistry-related topics. Alice has also created a project for and supervised a Masters student through their project during her PhD.

School of Pharmacy

University of Nottingham
University Park
Nottingham, NG7 2RD

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