I studied for my Bachelor's and Master's Degree majoring in Microbiology from the Department of Microbiology, University of Dhaka, Bangladesh. I grew a keen interest in research during my B.Sc. mini-research project where I studied HBV (Hepatitis B Virus) antibody titers of health care personnel of different diagnostic centers in the city of Dhaka, Bangladesh (2004-2005). Surprisingly more than 12% of carrier rates of HBV were confirmed among the participants. Later, we published a scientific paper in the local biomedical journal. The observed data from my B.Sc. research was timely and impactful and contributed to the national database. It also helped me to determine my career in the field of biomedical research. During my M.Sc. research, I studied closely with my supervisor, Prof. Anwar Hossain on the notorious arsenicosis problem in rural Bangladesh (2006-2007). From my M.Sc. research, I found a distinctive change in common microbial flora in the skin of people suffering from arsenic poison in their drinking water. In 2008, I joined my Ph.D. graduation program at Soonchunhyang University, South Korea. I obtained my Ph.D. in Medicine in 2011. My Ph.D. dissertation focused on the research of developing calcium phosphate-based biomaterials as well as understanding cell-material interaction on the biomaterial surfaces. Soon after receiving my Ph.D. degree, I joined the Department of Environmental Microbiology, Kyonggi University, Suwon, South Korea as a post-doctoral fellow in the June of 2011. Here, my research objective was to evaluate and establish a mixture of high efficient bacteria for controlling malodors and the biodegradability of carcasses through anaerobic and aerobic digesters. In 2013, I joined back to my Ph.D. supervisor's lab and worked there till the end of 2015 as a post-doctoral fellow. In Prof. Ho-Yeon Song's laboratory, I studied various agents including phytochemicals and intermediate bi-products of synthetic novel compounds for their anti-mycobacterial properties. Along with my team-mates, I screened many novel anti-mycobacterial agents and determined their possible mode of action. I also studied the effects of the novel drugs on mycobacterial cell wall mycolic acids through molecular and biochemical analyses. I maintained a wide variety of eukaryotic cell lines and designed and performed experiments to test in vitro cytotoxicity of the drugs as well. In December 2015 I gave up my job, came to the UK with my family, and took my first career break to look after my daughter. Although I took a brief career break for the sake of my family, I was always aware of the concurrent field of Biomedical Sciences in the UK. I found that the University of Nottingham sponsored Daphne Jackson Fellowship would be an excellent opportunity for me to retrain myself and come back into biomedical research. Under this great Fellowship scheme, I joined the School of Pharmacy in November 2020. Currently, I am working on the development of effective treatment of osteomyelitis disease under the supervision of Prof. Felicity Rose and Prof. Miguel Camara.
I received extensive training on different microbiological methods including bacterial cell cultures and propagation methods, extraction, isolation, and maintenance of bacterial DNA, RNA, Proteins, Well wall Mycolic acids, etc. Over the years of experience in different microbiology laboratories, I learned different microbiological, biomolecular, and biochemical analyses associated with different research works. I experienced knowledge in biomedical engineering which includes designing biomaterials and developing regenerative drugs as well as drug delivery systems. Due to my Ph.D. in CaP biomaterials and related works, I received experiences on how to evaluate the mechanical and biological properties of biomaterials as well. During my post-doctoral work, I maintained a wide variety of eukaryotic cell lines, and designed and performed experiments to test in vitro cytotoxicity, related mode of action, expression of proteins or molecules.
Osteomyelitis is a very hard-to-cure disease of bone, mainly caused by pathogenic and opportunistic microorganisms in the nosocomial environment. Just in osteomyelitis, the cost per patient to the… read more
Osteomyelitis is a very hard-to-cure disease of bone, mainly caused by pathogenic and opportunistic microorganisms in the nosocomial environment. Just in osteomyelitis, the cost per patient to the NHS is £60,000 on average. Infectious microbial biofilms usually create complications in the disease progression and protect themselves from antimicrobial treatment. A synergistic application of both antibiotic and quorum sensing inhibitors is very effective against the growth of microbial biofilms. In my current research, I am collaborating with an Industry, Ceramisys Ltd. Ceramisys develops bone graft materials containing hydroxyapatite (HA) and beta-tricalcium phosphate (β-TCP). Thus, my study aims to develop a novel system to combat osteomyelitis using antibiotics and quorum sensing inhibitors (QSI), both contained and released from HA/β-TCP porous granules (Ceramisys Ltd.).
My current research project has been granted by Daphne Jackson Trust and I am closely working with both Prof. Felicity Rose (School of Pharmacy, University of Nottingham) and Prof. Miguel Camara (School of Life Science, University of Nottingham). This study is particularly important to both basic scientists, the pharmaceutical industry, and clinicians because it will reveal a new way to treat infectious diseases caused by microbial biofilms.