School of Pharmacy
  • Print
   
   

Staff Listing 

Image of David Pritchard

David Pritchard

Professor of Parasite Immunology, Faculty of Science

Contact

Biography

I graduated from the University of Wales in 1973 with a BSc in Zoology. This was followed with an MSc in Immunology at the University of Birmingham in 1974 and I completed my PhD in Immunology in 1977. In 1977 I joined AstraZeneca, Loughborough, as an Industrial Research Scientist. In 1981 I joined the University of Nottingham as a MRC Postdoctoral Researcher, was promoted to Lecturer in Immunology, School of Biological Sciences, in 1983 and Reader in Immunology in 1991. In 1996 I was awarded a Wellcome Research Leave Fellowship which I undertook at the University of Leicester's Centre for Mechanisms of Human Toxicity. I joined the School of Pharmacy in 1998 as Chair in Parasite Immunology.

Research Summary

I am interested in the way a variety of organisms interact with the human body. Initially, I became interested in how and why nematode parasites stimulated the allergic phenotype. In an industrial… read more

Recent Publications

Current Research

I am interested in the way a variety of organisms interact with the human body. Initially, I became interested in how and why nematode parasites stimulated the allergic phenotype. In an industrial setting, we were then able to exploit this interaction to develop drugs to alter the allergic phenotype. This led me in turn to investigate the evolutionary basis for allergy per se. Through the establishment of tropical research bases, particularly in Papua New Guinea, on Karkar Island, we discovered that the hookworm parasite of humans, Necator americanus, was actually partially controlled by the allergic phenotype. In other words, allergy has value. However, the immunological balance appeared to fall in favour of the parasite. This led to the thesis that worm infection could be used therapeutically to counter-control allergy, and other immunological diseases, a thesis currently under active exploration in a number of laboratories worldwide. In a similar vein, we have studied Pseudomonas aeruginosa, and discovered that its chemical language, quorum sensing (QS), was active in suppressing the immune system, allowing the infection to thrive. Prospective outcomes of this research include the discovery of novel immune suppressive therapeutics, and vaccines against QS. In addition, we have recently discovered how the medicinal maggot Lucilia sericata cleans poorly healing wounds in patients. As a result, we have isolated several potential stand-alone wound management agents.

Recent invitations to speak: 2008 - 2011

Advanced Wound Care Group Discussion, Wounds UK, Harrogate

ESVD/ECVD Brussels

BSP Nottingham

BSACI Nottingham

The American Academy of Allergy, Asthma and Immunology, San Francisco

Innovations in Chronic Wound Management, University of Swansea

IOB/RSC York

ENTO 10 Swansea, Session Chair

ICOPA XII Melbourne, Keynote Speaker

Tanzania RDTC Moshi

Institute of Biology, Sheffield

Royal Society of Medicine London

EACCI, Warsawa

British Society for Parasitology, Session Chair and Speaker. Edinburgh.

British Association for the Advancement of Science, York

Dutch Society for Experimental Dermatology

British Dermatology Society

Ulster Immunology Group (BSI)

Keystone Symposium, Lake Tahoe, USA Pathogenesis and Immune Regulation in Helminth Infections (DNA)

Eijkmann Graduate School Masterclass and Symposium, UMC Utrecht

GA2LEN Paris

Hydra Conference Greece- Molecular and Cellular Biology of Helminth Parasites V (DNA)

Oxford University Biochemical Society (DNA)

Astra Zeneca Site Symposium

Department of Dermatology, University Hospital, Zurich

SIAF, Davos

School of Health Science, University of Swansea

Teaching

David Pritchard's course, B34UAB, The Immunobiology and Chemotherapy of Tropical Parasitic Infection, is attended by large class sizes and is particularly well attended by overseas students.

School of Pharmacy

University of Nottingham
University Park
Nottingham, NG7 2RD

For all enquiries please visit:
www.nottingham.ac.uk/enquiry