Fabrizio obtained a 5-year Pharmacy degree from Chieti-Pescara University in Italy (2011). After the pre-registration period, Fabrizio worked as a pharmacist before earning an MSc in Drug Delivery at the UCL School of Pharmacy (2015) with a research project focused on the development of tablets fabricated by fused deposition modelling (FDM) 3D printing. During this time Fabrizio's interest in drug delivery and 3D printing grew even more and a PhD in Pharmaceutics clearly became his ambition.
Development of osmotic tablets by 3D printing
Osmotic tablets are composed of a soluble core containing the drug, coated with a semi-permeable membrane. Water enters the tablet following the osmosis principle, and creates an internal pressure that allows the drug to be release through a 1mm orifice. In result, drug release follows a zero-order profile, avoiding plasma concentration peaks and fluctuations. Additionally, the release rate is essentially independent from external factors such as the different pH environment and presence of food in the stomach.
3D printing is an additive manufacturing technology with applications in myriad different fields including the recent production of medicines. The replacement of conventional drug manufacture and distribution could provide patients with personalized tablets fabricated at the point of care to reduce cost and enhance therapy adherence.
Particularly, during the first in human clinical studies, the manufacture on demand of oral formulations that release the drug within the same time, independently from drug content and external factors, would be an invaluable step forward.
Therefore, the aim of this project is to develop 3D printed osmotic formulations.