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Lluϊsa Pérez-García

Anne McLaren Research Fellow, Faculty of Science

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Biography

Lluïsa Pérez-García received her Pharmacy degree and PhD from the Universitat de Barcelona, for which she received full honours and the special prize of the University as well as the Rhône Poulenc prize for young scientists. After a two year stay at the University of Birmingham (UK) in Fraser Stoddart`s group she moved to the School of Pharmacy at the Universitat de Barcelona where she gained a post as tenured lecturer (1994) and then became an Associate Professor in the Organic Chemistry Laboratory of the School Pharmacy (1997). In 2009 she was accredited to full professor, and in the academic year 2015-16 she spent a sabbatical year at the University of Nottingham, where she has been recently appointed as an Anne McLaren Research fellow (September 2017).

In a management role, for five years (2004-2008) she was Vice-Dean of Research at the Faculty of Pharmacy and Deputy of the Vice-Rector of Scientific Policy at the University of Barcelona, being in charge of doctoral studies within the University

Expertise Summary

Research. Her interdisciplinary research experience is in synthetic, structural, medicinal and supramolecular chemistries. Her doctoral thesis involved the synthesis of heterocyclic betaines, of interest as anti-parasitic agents as well as building blocks for the construction of macrocyclic structures. During her two years as a postdoc in Birmingham she worked on the self-assembly of mechanically interlocked structures, such as catenanes and rotaxanes, as molecular switches. Back at the University of Barcelona she directed many research projects, including the preparation of anion binding macrocycles, the synthesis of new streptavidin ligands, and the search of nanobiosensors for pharmaceutical applications. Her current interests are mainly in the field of nanobiomedicine, and include the use of nanoparticles and hydrogels for drug delivery of anticancer agents -especially using photodynamic therapy-, and the bio-functionalization of micro- and nanoparticles to study, tag and actuate inside living cells (multiplexing materials).

Teaching. Dr Pérez-García has a long teaching record and also experience in teaching innovation in the University of Barcelona, and she has experience in teaching management as well as in new learning techniques and new techniques for pedagogy.

She has been involved in many research and innovative teaching projects, in many cases as the coordinator. Also, she has experience organizing international conferences (membership in the steering and/or programme committee).

Management. She has taken different research related institutional responsibilities in academia, including roles as Vice-Dean of Research at the Faculty of Pharmacy, Deputy of the Vice-Rector of Scientific Policy at the University of Barcelona, Member of the Directive Council of the Doctoral School-UB, and Member of the Directive Council of the IN2UB Institute of Nanoscience and Nanotechnology-UB.

Teaching Summary

Her teaching interests concentrate on transmitting to the students the relevance of deeply understanding, at the molecular level, the chemical and biological processes involved in the design,… read more

Research Summary

Her multidisciplinary research relies on the study of new materials with specific properties in the fields of organic, supramolecular and therapeutical chemistries. In particular, supramolecular… read more

Selected Publications

Her teaching interests concentrate on transmitting to the students the relevance of deeply understanding, at the molecular level, the chemical and biological processes involved in the design, preparation, characterization and use of pharmaceuticals and nanostructured materials for biological applications, especially for therapeutic purposes. She usually teaches Medicinal Chemistry at the undergraduate level, and Nanochemistry and Nanomedicine at the postgraduate level, in Master courses such as Nanoscience and Nanotechnology, Biomedical engineering, or Research, development and control of medicines.

Current Research

Her multidisciplinary research relies on the study of new materials with specific properties in the fields of organic, supramolecular and therapeutical chemistries. In particular, supramolecular chemistry is regarded as a tool to build up nanomaterials -through a bottom-up approach-, of interest in Nanomedicine. As such, it includes the bio-functionalization of inorganic and metallic surfaces with natural and synthetic receptors to obtain micro- and nanotools capable of interacting with biological material and sensing its function.

The overall objective is to prepare cellular sensors to monitor different cellular parameters in living cells, one the challenges being real-time monitoring. We also aim to understand and control the interaction between the so-prepared micro-and nanoplatforms and living matter. The two main approaches involve the preparation and testing of: a) tools to manipulate living cells from the outside, exploiting the interaction of bio-functionalized particles to modify some of the cell properties or functions either chemically or mechanically, and b) tools to be entirely introduced inside living cells, either as tags, sensors or actuators.

Some of her ongoing projects involve the preparation of silicon and gold nanoparticles as well as supramolecular hydrogels for drug delivery purposes, recently focusing on their application for Photodynamic Therapy. Also, the design and preparation of immobilized molecular switches for transporting and delivering intracellular cargos, and exploring different external stimuli triggering the on/off mechanism.

Specific research topics include:

  • Supramolecular chemistry
  • Template synthesis and self-assembly in organic synthesis
  • Anion recognition
  • Bio-functionalization of surfaces
  • Bio-Functionalization of micronanotools for tagging and actuate in living cells
  • Chemosensors and anions deliverers
  • Synthesis of intracellular sensors
  • Gold nanoparticles and hydrogels for drug delivery
  • Molecular machines and switches
  • Porphyrins for photodynamic therapy
  • Pharmaceuticals based on ionic liquids

Researcher unique identifiers:

Researcher ID: H-4384-2013

Orcid Number: 0000-0003-2031-4405

School of Pharmacy

University of Nottingham
University Park
Nottingham, NG7 2RD

For all enquiries please visit:
www.nottingham.ac.uk/enquiry