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Shruti Mittal

Research Fellow, Faculty of Science

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Biography

Dr. Shruti Mittal obtained her Bachelors and Masters degree in Zoology from University of Delhi, India in 2010. She received her PhD in Biophysics from University of Delhi (2015) under the supervision of Dr. Laishram Rajendrakumar Singh before moving to University of Paris, France for working towards her first postdoctoral project with Dr. David Tareste from 2016-2018. Dr. Mittal was then appointed as a Postdoctoral Research Associate at University of Oxford, UK in a 3-year MRC funded project that was a blend of biophysics and molecular biology.

Expertise Summary

Dr. Mittal has extensive expertise in the following:

- Recombinant protein expression and purification using different systems (Bacterial and Mammalian)

- Protein-free and Proteoliposome preparation via (i) Dialysis; (ii) Extrusion; (iii) Sonication.

- Lipid-protein interaction using Float-up assay, ELISA based assays (including Lipid Snoopers) and Flow Cytometry

- Protein structure, stability, thermal and chemical denaturation studies using optical probes

Teaching Summary

Dr. Mittal's teaching interests are in Biochemistry and Molecular Biology.

Research Summary

Helicobacter pylori (Hp) infects half of the world's population and is the leading cause of peptic ulceration and gastric adenocarcinoma, especially in low-income countries where the prevalence of Hp… read more

Recent Publications

Current Research

Helicobacter pylori (Hp) infects half of the world's population and is the leading cause of peptic ulceration and gastric adenocarcinoma, especially in low-income countries where the prevalence of Hp is very high compared to high-income countries. Additionally, there is a rising failure of drugs to eradicate Hp infections due to steadily increasing antimicrobial resistance. Aiming at reducing the burden of antibiotic resistant Hp infections, Dr. Mittal's current research is focused at creating an innovative and efficient targeted liposomal delivery system that can be used to target the increasing resistance of Hp.

Past Research

Dr. Mittal's research career in biophysics began while working towards her doctoral degree (2011-2015; Thesis title: Investigating Protein Folding and Aggregation under Conditions Mimicking Intracellular Crowded Environment) under the mentorship of Dr. Laishram RajendraKumar Singh at University of Delhi, India. The overall focus of her doctoral project aimed at investigating how protein structure, stability and aggregation are modulated under conditions mimicking the crowded intracellular environment using various spectroscopic techniques and thermodynamic approaches.

Dr. Mittal's postdoctoral project at University of Paris, France was a blend of biophysics and biochemistry, primarily focused on understanding how different lipids affect membrane fusion involving the preparation of artificial membranes (liposomes and proteoliposomes) followed by monitoring their fusion by FRET-based lipid-mixing assay.

Dr. Mittal's role as a Postdoctoral Research Associate at University of Oxford involved investigating lipid-protein interaction in the context of Notch signalling via ELISA based assays (including Lipid Snoopers) and Flow Cytometry.

School of Pharmacy

University of Nottingham
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Nottingham, NG7 2RD

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