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Harsimran Minhas

Research Fellow, Faculty of Science

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Biography

Dr Minhas gained her MSc from the University of Leicester in 2015. Her research project focused on developing peptide-oligonucleotide conjugates for DNA-templated synthesis of a protein beta-sheet, under the supervision of Dr Andrew Jamieson. She went on to complete a PhD in the first instance under the supervision of Dr Andrew Jamieson and Professor John Schwabe, developing a peptidomimetic histone deacetylase (HDAC) inhibitor containing an unnatural amino acid. She then moved to work under the supervision of Dr Alison Stuart developing new synthetic methodologies for hypervalent iodine(III)-mediated atom-transfer reactions. In August 2020 she moved to Nottingham for a Research Fellow position in Professor Weng Chan's laboratory.

Expertise Summary

Dr Minhas has a wide range of experience in peptide chemistry including developing a peptidomimetic Histone Deacetylase (HDAC) inhibitor and developing peptide-oligonucleotide conjugates to study Alzheimer's disease. She also has a wealth of experience in hypervalent iodine(III) chemistry and fluorine chemistry, focusing on developing new and efficient methodology to introduce chlorine and fluorine into small molecules. In her final year she gained an interest in hypervalent iodine(III) mediated enantioselective chlorination for pharmaceutical application.

Research Summary

Dr Minhas' research primarily focuses on rational chemical design and a multi-disciplinary approach to investigate biomolecular interactions and developing lead drug candidates. Dr Minhas is… read more

Recent Publications

  • MINHAS, HARSIMRAN K., RILEY, WILLIAM, STUART, ALISON M. and URBONAITE, MARTYNA, 2018. Activation of the hypervalent fluoroiodane reagent by hydrogen bonding to hexafluoroisopropanol ORGANIC & BIOMOLECULAR CHEMISTRY. 16(39), 7170-7173

Current Research

Dr Minhas' research primarily focuses on rational chemical design and a multi-disciplinary approach to investigate biomolecular interactions and developing lead drug candidates. Dr Minhas is interested in developing novel chemical agents capable of attenuating virulence in stapylococcal infections by targeting the staphylococcal quorum sensing system.

  • MINHAS, HARSIMRAN K., RILEY, WILLIAM, STUART, ALISON M. and URBONAITE, MARTYNA, 2018. Activation of the hypervalent fluoroiodane reagent by hydrogen bonding to hexafluoroisopropanol ORGANIC & BIOMOLECULAR CHEMISTRY. 16(39), 7170-7173

School of Pharmacy

University of Nottingham
University Park
Nottingham, NG7 2RD

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