Recent publications from the School of Pharmacy. The most recent publications are shown first.
Upper critical solution temperature thermo-responsive polymer brushes and a mechanism for controlled cell attachment
New found hope for antibiotic discover: lipid II inhibitors
5-Hydroxyethyl-3-tetradecanoyltetramic acid represents a novel treatment for intravascular catheter infections due to Staphylococcus aureus
MiR137 is an androgen regulated repressor of an extended network of Transcriptional coregulators
Starting antidepressant use:a qualitative synthesis of UK and Australian data
Effectiveness of the New Medicine Service in community pharmacies in England. BMJ Quality and Safety 2015
Receptor Crosslinking: A General Method to Trigger Internalization and Lysosomal Targeting of Therapeutic Receptor:Ligand Complexes
Structural basis of Lewisb antigen binding by the Helicobacter pylori adhesin BabA
Synthesis of 19F nucleic acid–polymer conjugates as real-time MRI probes of biorecognition
New biomaterials from renewable resources – amphiphilic block copolymers from δ-decalactone
Systemic in vivo delivery of siRNA to tumours using combination of polyethyleneimine and transferrin–polyethyleneimine conjugates
Investigating the Impact of ‘Better Care Better Value’ prescribing policy on the Utilisation of Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers for Treating Hypertension in the UK Primary Care Setting.: longitudinal quasi-experimental design.
Discovery of a Novel Polymer for Human Pluripotent Stem Cell Expansion and Multilineage Differentiation
The enzyme activities of Caf1 and Ccr4 are both required for deadenylation
by the human Ccr4–Not nuclease module
Triblock Copolymer Nanovesicles for pH-Responsive Targeted Delivery and Controlled Release of siRNA to Cancer Cells
In vitro properties of designed antimicrobial peptides that exhibit potent antipneumococcal activity and produces synergism in combination with penicillin
Heparin molecularly imprinted surfaces for the attenuation of complement activation in blood
Cost-Effectiveness of a Specialist Geriatric Medical Intervention for Frail Older People Discharged from Acute Medical Units: Economic Evaluation in a Two-Centre Randomised Controlled Trial (AMIGOS)
A Survey of Pharmacy Education in Thailand
Synthesis of New DPP-4 Inhibitors Based on a Novel Tricyclic Scaffold
Characterisation of human saliva as a platform for oral dissolution medium development
Kinetic Analysis of Antagonist-Occupied Adenosine-A3 Receptors Within Membrane Microdomains of Individual Cells Provides Evidence of Receptor Dimerization and Allosterism
Revealing cytokine-induced changes in the extracellular matrix with secondary ion mass spectrometry
A facile approach to tryptophan derivatives for the total synthesis of argyrin analogues
The development and validation of the Satisfacton Questionnaire for Osteoporosis Prevention in Malaysia
Materials for stem cell factories of the future (PDF)
Materials for the stem cell factories of the future are discussed in this review article by Celiz et al. published in Nature Materials (June 2014).
Well-defined materials are required to allow cell banking and to provide the raw material for reproducible differentiation into lineages for large-scale drug-screening programs and clinical use. Yet more than 1 billion cells are needed for each patient to replace losses during heart attack, multiple sclerosis and diabetes. Producing this number of cells is challenging, and a rethink of the current predominant cell-derived substrates is needed to provide technology that can be scaled to meet the needs of millions of patients a year. The role of materials discovery is explored and a methodology proposed to develop the necessary materials.
Dissolution methodology for taste masked oral dosage forms
“It’s easier in pharmacy”: why some patients prefer to pay for flu jabs rather than use the National Health Service
Structure and Catalytic Regulatory Function of Ubiquitin Specific Protease 11 N-Terminal and Ubiquitin-like Domains
Targeting Staphylococcus aureus Quorum Sensing with Non-Peptidic Small Molecule Inhibitors
Programmable polymer-DNA hydrogels with dual input and multiscale responses
Giovanna Sicilia, Christine Grainger-Boultby, Nora Francini, Johannes P. Magnusson, Aram O. Saeed, Francisco Fernández-Trillo, Sebastian G. Spain and
, 2013, Advance Article
DOI: 10.1039/C3BM60126A 04 Oct 2013
The Identification of Seniors at Risk (ISAR) score to predict clinical outcomes and health service costs in older people discharged from UK acute medical units
Judi Edmans, Lucy Bradshaw , John R. F. Gladman , Matthew Franklin , Vladislav Berdunov , Rachel Elliott and Simon P. Conroy
Age Ageing (2013) doi: 10.1093/ageing/aft054
First published online: May 10, 2013
Oral Treatment Targeting the Unfolded Protein Response Prevents Neurodegeneration and Clinical Disease in Prion-Infected Mice
Julie A. Moreno, Mark Halliday, Colin Molloy, Helois Radford, Nicholas Verity, Jeffrey M. Axten, Catharine A. Ortori, Anne E. Willis, Peter M. Fischer, David A. Barrett and Giovanna R. Mallucci.
Sci Transl Med 5, 206ra138 (2013)
Harnessing patients’ awareness of adverse reactions to the drugs they take. Chapter in Ziebland S, Coulter A, Calabrese JD. Understanding and Using Health Experiences . Oxford University Press, Oxford 2013.
Distribution and Visualisation of Chlorhexidine Within the Skin Using ToF-SIMS: A Potential Platform for the Design of More Efficacious Skin Antiseptic Formulations,
Pharmaceutical research, 30 (7) 1896-905 (2013) Judd, A.M., Scurr, D.J., Heylings, J.R., Wan, K.-W., Moss, G.P.
Mapping the Pharyngeal and Intestinal pH of Caenorhabditis elegans and Real-Time Luminal pH Oscillations Using Extended Dynamic Range pH-Sensitive Nanosensors
ACS Nano, 2013, 7 (6), pp 5577–5587
Veeren M. Chauhan, Gianni Orsi, Alan Brown ,David I. Pritchard , and Jonathan W. Aylott
PRAME Is a Golgi-Targeted Protein That Associates with the Elongin BC Complex and Is Upregulated by Interferon-Gamma and Bacterial PAMPs
Frances R. Wadelin, Joel Fulton, Hilary M. Collins, Nikolaos Tertipis, Andrew Bottley, Keith A. Spriggs, Franco H. Falcone, David M. Heery*
PLOS ONE www.plosone.org Feb 2013 Vol 8 Issue 2 e58052
This paper has been rated as highly accessed due to the very high number of downloads in the first few weeks:
HM Collins, MK Abdelghany, M Messmer, B Yue, SE Deeve, KB Kindle, K Mantelingu, A Aslam, GS Winkler, TK Kundu, DM Heery.
Differential effects of garcinol and curcumin on histone and p53 modifications in tumour cells. BMC Cancer.2013, 13:37. DOI: 10.1186/1471-2407-13-37 URL: http://www.biomedcentral.com/1471-2407/13/37
Electrospun PLGA fibre sheets incorporating fluorescent nanosensors: self-reporting scaffolds for application in tissue engineering H. C. Harrington, F. R. A. J. Rose, Y. Reinwald, L. D. K. Buttery, A. M. Ghaemmaghamic and J. W. Aylott Analyt.Methods 2013 ,5 ,68
Short description: Self-reporting scaffolds, consisting of polymer fibres containing nanosensors, offer the potential of in situ, real-time assessment of the microenvironment in 3D constructs during the tissue growth process
Combinatorial discovery of polymers resistant to bacterial attachment
Andrew L Hook, Chien-Yi Chang, Jing Yang, Jeni Luckett, Alan Cockayne,
Steve Atkinson, Ying Mei, Roger Bayston, Derek J Irvine, Robert Langer,
Daniel G Anderson, Paul Williams, Martyn C Davies & Morgan R Alexander
Nature Biotechnology Volume: 30, Pages: 868–875
Year published: (2012)
Anti-Fas/CD95 and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) differentially regulate apoptosis in normal and neoplastic human basophils.
Förster A, Falcone FH, Gibbs BF, Preussner LM, Fiebig BS, Altunok H, Seeger JM, Cerny-Reiterer S, Rabenhorst A, Papenfuss K, Valent P, Kashkar H, Hartmann K,
The following paper was highlighted Paper of the Week in Polymer Chemistry:
Well-defined Polymeric Vesicles with High Stability and Modulation of Cell Uptake by a Simple Coating Protocol.
Yaşayan, G.; Redhead, M.; Magnusson, J. P.; Spain, S. G.; Allen, S.; Davies, M. C.; Alexander, C and Fernandez-Trillo, F. Polymer Chemistry 2012, 3, 2596-2604. (RSC ‘Hot’ article)
Synthetic peptides derived from an N-terminal domain of the E2 protein of GB virus C in the study of GBV-C/HIV co-infection.
Fernández, L., Chan, W.C., Egido, M., Gómara, M.J. and Haro, I. (2012), J. Pept. Sci., 18, 326-335.
Methicillin resistance reduces the virulence of HA-MRSA by interfering with the agr quorum sensing system.
Ruskin, J.K., Edwards, A.M., Bowden, M.G., Brown, E.L., Piozzi, C., Waters, E., Chan, W.C., Williams, P., O’Gara, J. and Massey, R.C. (2012), J. Infect. Dis., 205, 798-806.
Professional skills development in a resource-poor setting: the case of pharmacy in Malawi
Zoe Lim , C. Anderson , S. McGrath
International Journal of Educational Development 32 (2012) 654–664
A pharmacist-led information technology intervention for medication errors (PINCER): a multicentre, cluster randomised, controlled trial and cost-effectiveness analysis Prof Anthony J Avery MD, Sarah Rodgers PhD , Prof Judith A Cantrill MSc, Sarah Armstrong PhD, Kathrin Cresswell PhD, Martin Eden MRes, Prof Rachel A Elliott PhD, Rachel Howard PhD, Prof Denise Kendrick DM, Caroline J Morris PhD h, Prof Robin J Prescott PhD, Glen Swanwick, Matthew Franklin MSc, Koen Putman PhD, Matthew Boyd PhD, Prof Aziz Sheikh PhD
The Lancet, Volume 379, Issue 9823, Pages 1310 - 1319, 7 April 2012
This paper has been highlighted by Molecular Pharmaceutics: 'Please enjoy this free sample issue of Molecular Pharmaceutics', your source for the latest, high-quality research at the interface of drug discovery and drug development.
Multicomponent Synthetic Polymers with Viral-Mimetic Chemistry for Nucleic Acid Delivery Mahmoud Soliman, Rujikan Nasanit, Samer R. Abulateefeh, Stephanie Allen, Martyn C. Davies, Simon S. Briggs, Leonard W. Seymour, Jon A. Preece, Anna M. Grabowska, Susan A. Watson and Cameron Alexander
Molecular Pharmaceutics 2012, 9, 1−13
Surface engineered substrates for improved human pluripotent stem cell culture under fully defined conditions.Saha, K.; Mei, Y.; Reisterer, C. M.; Pyzocha, N.; Yang, J.; Muffat, J.; Mitalipova, M.; Davies, M. C.; Alexander, M. R.; Langer, R.; Anderson, D. G.; Jaenisch, R., Proc. Natl. Acad. Sci. USA 2011, 108, (46), 18714-18719.
Saha, K.; Mei, Y.; Reisterer, C. M.; Pyzocha, N.; Yang, J.; Muffat, J.; Mitalipova, M.; Davies, M. C.; Alexander, M. R.; Langer, R.; Anderson, D. G.; Jaenisch, R., .
Protein Unfolding under Force: Crack Propagation in a Network
de Graff, Adam M. R.; Shannon, Gareth; Farrell, Daniel W.; Williams, Philip M.; Thorpe, M. F. BIOPHYSICAL JOURNAL Vol 101, Issue 3 Pages 736-744 DOI:10.1016/j.bpj.2011.05.072 Published: AUG 3 2011
Dr Roger Knaggs (Chair of UKCPA Pain Management Group) and Professor David Taylor and Dr Jennifer Gill (UCL School of Pharmacy) “Relieving Persistent Pain: Improving Health Outcomes”
Multicomponent Synthetic Polymers with Viral-Mimetic Chemistry for Nucleic Acid Delivery
Mahmoud Soliman, Rujikan Nasanit, Samer R. Abulateefeh, Stephanie Allen, Martyn C. Davies, Simon S. Briggs, Leonard W. Seymour, Jon A. Preece, Anna M. Grabowska, Susan A. Watson and Cameron Alexander
Molecular Pharmaceutics, 2012, 9, 1−13
This paper describes the first time dual action materials have been prepared that can bind bacterial signals as well as bacterial cells. The citation in Angewandte reads:
“Double agents: Dual-action polymers are able to sequester rapidly the marine organism Vibrio harveyi from suspension, while at the same time quenching bacterial quorum sense (QS) signals (see picture). The potency of the polymers is assessed by cell aggregation experiments and competitive binding assays against a QS signal precursor, and their effect on bacterial behavior is shown by means of bioluminescence.”
Synthetic Polymers for Simultaneous Bacterial Sequestration and Quorum Sense Interference
Xuan Xue, Dr. George Pasparakis, Dr. Nigel Halliday, Dr. Klaus Winzer, Prof. Steven M. Howdle, Dr. Christopher J. Cramphorn, Prof. Neil R. Cameron, Dr. Paul M. Gardner, Prof. Benjamin G. Davis, Dr. Francisco Fernández-Trillo, Prof. Cameron Alexander
Angewandte Chemie International Edition
Volume 50, Issue 42, pages 9852–9856, October 10, 2011
Directed Differentiation of Human Embryonic Stem Cells to Interrogate the Cardiac Gene Regulatory Network
Dixon James E.; Dick Emily; Rajamohan Divya; et al.
MOLECULAR THERAPY Volume: 19 Issue: 9 Pages: 1695-1703 DOI: 10.1038/mt.2011.125
Factors affecting the formation of insulin amyloid spherulites
Michael I. Smith, Vito Foderà, James S. Sharpa, Clive J. Roberts, Athene M. Donald
Colloids and Surfaces B: Biointerfaces
The importance of direct patient reporting of suspected adverse drug reactions: a patient perspective
Claire Anderson, Janet Krska, Elizabeth Murphy & Anthony Avery on behalf of the Yellow Card Study Collaboration
British Journal of Clinical Pharmacology 1365 -2125 April 2011
Polymer control of ligand display on gold nanoparticles for multimodal switchable cell targeting
Francesca Mastrotto, Paolo Caliceti, Vincenzo Amendola, Sara Bersani, Johannes Pall Magnusson, Moreno Meneghetti, Giuseppe Mantovani, Cameron Alexander and Stefano Salmaso
Chem. Commun., 2011, 47, 9846–9848
Protein Unfolding under Force: Crack Propagation in a Network
Adam M. R. de Graff, Gareth Shannon, Daniel W. Farrell, Philip M. Williams, and M. F. Thorpe
Biophysical Journal Volume 101 August 2011 736–744
A recent publication about Raman mapping:
Confocal Raman Microscope Mapping of a Kofler Melt; Alkhalil, A; Nanubolu, JB; Roberts, CJ; Aylott JW and Burley JC; CRYSTAL GROWTH & DESIGN Volume: 11 Issue: 2 Pages: 422-430 Published: 2011
"We demonstrated for the first time the use of Raman mapping to investigate the formation of co-crystals of nicotinamide and flurbiprofen. This opens up the possibility of rapid and automated screening of new pharmaceutical dosage forms."
Reddy TRK, Li C, Guo X, Myrvang HK, Fischer PM, Dekker L V . Design, Synthesis, and SAR Exploration of 1-Substituted 4-Aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one Analogs as Inhibitors of the Annexin A2–S100A10 Protein Interaction. Journal of Medicinal Chemistry, (2011) 54, 2080-2094
Patient Education and Counselling 83 (2011) 423-431
Analysis of pharmacist-patient communication using the Calgary-Cambridge guide N Greenhill, C Anderson, A Avery, A Pilnick
miR-122 activates hepatitis C virus translation by a specialized mechanism requiring particular RNA components Roberts, APE, Lewis, AP, Jopling, CL.Nucleic Acids Research ( 2011 ) doi: 10.1093/nar/gkr426
Sequence determinants for the tandem recognition of UGU and CUG rich RNA elements by the two N—terminal RRMs of CELF1
Nucleic Acids Research (2011)
John Edwards, Emilie Malaurie, Alexander Kondrashov, Jed Long, Cornelia H. de Moor, Mark S. Searle, and Jonas Emsley
End-stapled homo and hetero collagen triple helices: A click chemistry approach.
Byrne, C., McEwan, P.A., Emsley, J., Fischer, P.M. and Chan, W.C.* (2011) Chemical Communications, 47, 2589-2591.
A recent publication on the Anti AIDS drug Etravirine
Physicochemical properties of the amorphous drug, cast films and spray dried powders to predict formulation probability of success for solid dispersions: Etravirine
Weuts I, Van Dycke F, Voorspoels J, De Cort S, Stokbroekx S, Leemans R, Brewster ME, Xu D, Segmuller B, Turner YT, Roberts CJ, Davies MC, Qi S, Craig DQ, Reading M.
Journal of Pharmaceutical Sciences 100, NO. 1, JANUARY 2011
Effect of pay for performance on the management and outcomes of hypertension in the United Kingdom: interrupted time series study
Brian Serumaga, Harvard Medical School fellow in pharmaceutical policy research, Dennis Ross-Degnan, associate professor and director of research, Anthony J Avery, professor, Rachel A Elliott, professor, Sumit R Majumdar, professor, Fang Zhang, statistician and instructor, Stephen B Soumerai, professor
BMJ 2011; 2011; 342:d108 (Published 25 January 2011)
Parallel Scanning Near-Field Photolithography: The Snomipede
Ehtsham ul Haq, Zhuming Liu, Yuan Zhang, Shahrul A. Alang Ahmad, Lu-Shin Wong, Steven P. Armes, Jamie K. Hobbs, Graham J. Leggett, Jason Micklefield, Clive J. Roberts, and John M. R. Weaver
Nano Lett., Article ASAP
Publication Date (Web): October 14, 2010
Understanding chemotherapy treatment pathways of advanced colorectal cancer patients to inform an economic evaluation in the United Kingdom
FH Shabaruddin, RA Elliott, JW Valle, WG Newman and K Payne
British Journal of Cancer (2010) 103, 315 – 323 (impact factor 4.85, 33/127 Oncology).
Leucine-rich repeat protein PRAME: expression, potential functions and clinical implications for leukaemia.
Wadelin F, Fulton J, McEwan PA, Spriggs KA, Emsley J, Heery DM.
Molecular Cancer. 2010 Aug 27;9(1):226.
Engineering Embryonic Stem-Cell Aggregation Allows an Enhanced Osteogenic Differentiation In Vitro
Author(s): Gothard D, Roberts SJ, Shakesheff KM, et al.
Source: TISSUE ENGINEERING PART C-METHODS Volume: 16 Issue: 4 Pages: 583-595 Published: AUG 2010.
Responsive polyelectrolyte complexes for triggered release of nucleic acid therapeutics
Soliman, M.; Allen, S.; Davies, M. C. and Alexander, C.
Chemical Communications 2010,46, 5421-5433.
Subcellular localisation of the p40phox component of NADPH oxidase involves direct interactions between the Phox homology domain and F-actin
Dongmin Shaoa, Anthony W. Segala and Lodewijk V. Dekker
The International Journal of Biochemistry and Cell Biology Vol 42 Issue 10 Oct 2010 p1736-1743
Combinatorial Development of Biomaterials for Clonal Growth of Human Pluripotent Stem Cells.
Mei, Y.; Saha, K.; Bogatyrev, S. R.; Yang, J.; Hook, A. L.; Kalcioglu, I.; Cho, S.-W.; Mitalipova, M.; Pyzocha, N.; Rojas, F.; Vliet, K. J. V.; Davies, M. C.; Alexander, M. R.; Langer, R.; Jaenisch, R.; Anderson, D. G.,
Nature Materials 2010, 9, 768-778.
Community pharmacists’ views on adverse drug reactions reporting in Malaysia: a pilot study
Kang-Nee Ting, Dane Michael Stratton-Powell and Claire Anderson
Pharmacy World & Science: Volume 32, Issue 3 (2010), Page 339
The extended release properties of HPMC matrices in the presence of dietary sugars
Hywel D Williams, Robert Ward, Ian J Hardy, Colin D Melia
Journal of Controlled Release 138 (2009) 251-259
5-Carboxyfluorescein tagged N-phenylanthranilamide as a tracer reagent for fluorescence polarization: a robust method to screen MAPK pathway allosteric inhibitors.
Rezvani, Z.N., Mayer, R.J. and Chan, W.C.(2010) Chem. Commun., 46, 2043-2045
'MOZ-TIF2 Mediated Destruction of CBP/p300 is Blocked by Calpain Inhibitor 2'
is now published online in Leukemia
p38 MAPK/MK2-mediated induction of miR-34c following DNA damage prevents Myc-dependent DNA replication.
Cannell IG, Kong YW, Johnston SJ, Chen ML, Collins HM, Dobbyn HC, Elia A, Kress TR, Dickens M, Clemens MJ, Heery DM, Gaestel M, Eilers M, Willis AE, Bushell M.
Proc Natl Acad Sci U S A . 2010 Mar 8. [Epub ahead of print]PMID: 20212154 [PubMed - as supplied by publisher]
Structure and function of factor XI.
Emsley J, McEwan PA, Gailani D.
Blood . 2010 Jan 28. [Epub ahead of print]PMID: 20110423 [PubMed - as supplied by publisher]
Alyamani, N. A., Smith, M. D., Williams, D. J. and Petty, R. D. (2010). “Predictive biomarkers for personalised anti-cancer drug use: discovery to clinical implementation ”, European Journal of Cancer , 46(5), 869-879, 2010.
High throughput methods applied in biomaterial development and discovery
Biomaterials 31 (2010) 187–198
Andrew L. Hook , Daniel G. Anderson , Robert Langer , Paul Williams , Martyn C. Davies , Morgan R. Alexander
A Novel role for a transcription factor in regulating genomic integrity
Gene Promoters Direct MicroRNA Action
Learning to prescribe - pharmacists’ experiences of supplementary prescribing training in England
Switch the light on: Nanoparticles for protease sensing
Understanding the language of cell-to-cell communication in Staphylococcus aureus
Cells in Gels
How protein molecules aggregate to form fibres
Proteins under pressure: a new way to design drugs!
Study of a cancer-causing protein provides new insights into the way proteins are made by the cell
Medicine use reviews: community pharmacists believe they’re good for pharmacy but struggle to fit them in to their other work
Developing a bandage for the eye