School of Pharmacy
   
   
  

Publications by the Molecular Therapeutics and Formulation division

 

  1. Bioreducible cross-linked core polymer micelles enhance in vitro activity of methotrexate in breast cancer. Biomaterials Science 2017 DOI: 10.1039/c6bm00888g Gulfam, M.; Matini, T.; Monteiro, P. F.; Riva, R.; Collins, H.; Spriggs, K. A.; Howdle, S. M.; Jérôme, C. and Alexander, C. 
  2. Tumour regression and improved gastrointestinal tolerability from controlled release of SN-38 from novel polyoxazoline-modified dendrimers. Journal of Controlled Release 2017 247, 73-85.Hare, J. I.; England, R. M.; Barnes, J. R.; Wilson, J.; Smith, A.; Kemmitt, P. D.; Strittmatter, N.; Waring, M. J.; Alexander, C.; Barry, S. T. and Ashford, M. B. 
  3. A novel DFP tripeptide motif interacts with the coagulation factor XI apple 2 domainBlood 2016, 127(23), 2915-23.Wong, Szu S, Ostergaard, Soren, Hall, Gareth, Li, Chan, Williams, Philip M, Stennicke, Henning And Emsley, Jonas. 
  4. Linking in Vitro Lipolysis and Microsomal Metabolism for the Quantitative Prediction of Oral Bioavailability of BCS II Drugs Administered in Lipidic Formulations. Mol. Pharmaceutics, 2016, 13 (10), pp 3526–3540.Benito-Gallo P, Marlow M, Zann V, Scholes P, Gershkovich P. 
  5. Taha DA, De Moor CH, Barrett DA, Lee JB, Gandhi RD, Hoo CW, Gershkovich P. The role of acid-base imbalance in statin-induced myotoxicity. Transl Res. 2016 Aug; 174:140-160.e14.
  6. PEGylation of paclitaxel largely improves its safety and anti-tumor efficacy following pulmonary delivery in a mouse model of lung carcinoma.J Control Release. 2016 Oct 10;239:62-71. doi: 10.1016/j.jconrel.2016.08.008 Luo T, Loira-Pastoriza C, Patil HP, Ucakar B, Muccioli GG, Bosquillon C, Vanbever R. 
  7. One-pot RAFT and fast polymersomes assembly: a “beeline ” from monomers to drug-loaded nanovectorsPolym. Chem., 2016, Advance Article DOI: 10.1039/C6PY01292B. Mastrotto, F.; Breen, A.; Sicilia, G.; Johnstone, G. A.; Marsh, G. E.; Murdan, S.; Grainger-Boultby, C.; Russell, N.; Alexander, C. and Mantovani, G. 
  8. Amphiphilic block copolymers from renewable monomers: prediction and characterisation of core chemistry effects on indomethacin encapsulation and release.J. Mater. Chem. B, 2016, Accepted Manuscript. DOI: 10.1039/C6TB01839D Kakde, D.; Taresco, V.; Bansal, K. K.; Magennis, E. P.; Howdle, S. M.; Irvine, D. J.; Mantovani, G. and Alexander, C. 
  9. Synthesis, Characterisation and Evaluation of In Vitro Toxicity in Hepatocytes of Linear Polyesters with Varied Aromatic and Aliphatic Co-monomersJournal of Controlled Release (2016) doi:10.1016/j.jconrel.2016.08.003 in press.Kakde, D.; Powell, L. G.; Bansal, K. K.; Howdle, S. M.; Irvine, D. J.; Mantovani, G.; Millar, G.; Dailey, L. A.; Stone, V.; Johnston, H. J. and Alexander, C. 
  10. Synthesis of 19F Nucleic Acid–Polymer Conjugates as Real-Time MRI Probes of Biorecognition.Polymer. Chemistry, 2016, 7, 2180 – 2191. Selected for Inside Front Cover. Sicilia, G.; Davis, A. L.; Spain, S. G.; Magnusson, J. P.; Boase, N. R. B.; Thurecht, K. J. and Alexander, C. 
  11. Variation in structure and properties of poly(glycerol adipate) via control of chain branching during enzymatic synthesisPolymer Accepted manuscript (unedited version) available online: 17-FEB-2016 DOI: 10.1016/j.polymer.2016.02.036 Taresco V., Creasey R.G. ,Kennon J., Mantovani G., Alexander C., Burley J.C.,Garnett M.C. 
  12. The effect of protein concentration on the viscosity of a recombinant albumin solution formulationRSC Advances. 2016, 6, 15143-15154.Domingues-Goncalves, A.; Alexander, C.; Roberts, C. J.; Spain, S. G.; Uddin, S.; Allen, S. 
  13. Live Imaging of Cellular Internalization of Single Colloidal Particle by Combined Label-Free and Fluorescence Total Internal Reflection Microscopy,  Molecular  Pharmaceutics, 2015, 12 (11), 3862–3870. Gerard D. Byrne, Driton Vllasaliu, Franco H. Falcone, Michael G. Somekh and Snjezana Stolnik, 
  14. Structural basis of Lewisb antigen binding by the Helicobacter pylori adhesin BabAScience  Advances 2015 (1) e1500315 DOI: 10.1126/sciadv.1500315. N Hage, T Howard, Chris Phillips, C Brassington, R Overman, J Debreczeni, P Gellert , S Stolnik, G S Winkler, F H  Falcone, 
  15. An internal ribosome entry site in the 5' untranslated region of epidermal growth factor receptor allows hypoxic expression.Oncogenesis. 2015 Jan 26;4:e134. doi: 10.1038/oncsis.2014.43. Webb TE, Hughes A, Smalley DS, Spriggs KA. 
  16. The malignant phenotype in breast cancer is driven by eIF4A1-mediated changes in the translational landscape.Cell Death Dis. 2015 Jan 22;6:e1603. doi:10.1038/cddis.2014.542 Modelska A, Turro E, Russell R, Beaton J, Sbarrato T, Spriggs K, Miller J, Gräf S, Provenzano E, Blows F, Pharoah P, Caldas C, Le Quesne J. 
  17. 3D printing of five-in-one dose combination polypill with defined immediate and sustained release profilesJOURNAL OF CONTROLLED RELEASE 2015  Volume: 217   Pages: 308-314 Khaled, Shaban A.; Burley, Jonathan C.; Alexander, Morgan R.; et al. 
  18. Monitoring the Dissolution Mechanisms of Amorphous Bicalutamide Solid Dispersions via Real-Time Raman Mapping.MOLECULAR PHARMACEUTICS 2015  Volume: 12   Issue: 5   Pages: 1512-1522 Tres, Francesco; Patient, Jamie D.; Williams, Philip M.; et al. 
  19. Microprocessor mediates transcriptional termination of long noncoding RNA transcripts hosting microRNAs.Nat. Struc. Mol. Biol. (2015) 22: 319-327. Dhir, A., Dhir, S., Proudfoot, N.J. and Jopling, C.L. 
  20. Genome-wide analysis of PAPS1-dependent polyadenylation identifies novel roles for functionally specialized poly(A) polymerases in Arabidopsis thaliana.PLOS Genetics, 11, e1005474. Kappel, C., Trost, G., Czesnick, H., Ramming,A., Kolbe, B., Vi, S.L. Bispo,C.,. Becker, J.D. De Moor, C.H. and Lenhard, M. (2015) 
  21. Insights into the influence of the cooling profile on the reconstitution times of amorphous lyophilized protein formulations European Journal of Pharmaceutics and Biopharmaceutics. 2015, 96, 247-254. Beech, K. E., Biddlecombe, J. G., Van der Walle, C. F., Stevens, l. A., Rigby, S. P., Burley, J. C. and Allen, S. 
  22. Mechanisms of Nanoparticle Internalization and Transport Across an Intestinal Epithelial Cell Model: Effect of Size and Surface ChargeMolecular Pharmaceutics 2014 ( 11) 4363–4373 Bannunah AM, D Vllasaliu, J Lord and S Stolnik, 
  23. Multiplexing spheroid volume, resazurin and acid phosphatase viability assays for high-throughput screening of tumour spheroids and stem cell neurospheres.PLoS One 2014 9(8): e103817. doi:10.1371/journal.pone.0103817 Ivanov, D.; Parker, T.; Walker, D.; Alexander, C.; Ashford, M.; Gellert, P. and Garnett, M. C. 
  24. Use of humanised rat basophilic leukaemia cell line RS-ATL8 for the assessment of allergenicity of Schistosoma mansoni proteins.PLoS Negl Trop Dis. 2014 Sep 25;8(9):e3124. doi: 10.1371/journal.pntd.0003124. Wan D, Ludolf F, Alanine DG, Stretton O, Ali Ali E, Al-Barwary N, Wang X, Doenhoff MJ, Mari A, Fitzsimmons CM, Dunne DW, Nakamura R, Oliveira GC, Alcocer MJ, Falcone FH. 
  25. Bacteria-instructed synthesis of polymers for self-selective microbial binding and labelling.Nature Materials 2014, 13, 748–755. Magennis, E. P.; Fernandez-Trillo, F.; Sui, S.; Spain, S. G.; Bradshaw, D.; Churchley, D.; Mantovani, G.; Winzer, K. and Alexander, C. 
  26. The P body protein LSm1 contributes to stimulation of hepatitis C virus translation, but not replication, by microRNA-122.Nuc. Acids Res.  (2014) 42: 1257-1269. Roberts, A.P.E., Doidge, R., Tarr, A.W. and Jopling, C.L. 
  27. Inhibition of polyadenylation reduces inflammatory gene inductionRNA  18, 2236-2250.Kondrashov, A., Meijer, H.A., Barthet-Barateig, A., Parker, H.N., Khurshid, A., Tessier, S., Sicard, M., Knox, A.J., Pang, L. and De Moor, C.H. (2012).

 

 

 

 

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