Research in this theme focuses on understanding how to get a particular molecular therapy into patients effectively and efficiently. We look at new processes for formulating molecules into medicines and for understanding these formulation processes.
Examples include: real-time chemical imaging and mechanistic modelling of tablet dissolution; micro-array formats for formulation screening at the nano-gram scale; stabilising amorphous solid dispersions; and controlling crystallisation.
Characterisation approaches include: spectroscopy (infra-red and Raman); X-ray diffraction; optical imaging and image analysis; and thermal characterisation (differential scanning calorimetry and thermo-gravimetric analysis).
Molecular informatics approaches are also used to develop predictive models about how a particular molecule will interact with excipients in a formulation.
Tres, F. et al. Mol. Pharmaceutics, 2015, 12 (5), pp 1512–1522
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