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Margareta Clarke

PhD student, Faculty of Science

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Biography

Following my graduation with a degree in Neuroscience from the University of Nottingham, I became a research assistant at the Division of Clinical Neurology, Queen's Medical Centre in Nottingham. During that time I assisted in the running of studies at the department including patient recruitment and writing up grant/ethics applications. I was actively involved in studies exploring cognition and the 'central vein sign' in multiple sclerosis (MS). The following year I started my PhD in the same department and commenced work on four projects which focus on exploring the role of MRI in MS research.

Expertise Summary

Due to the diverse theme of my PhD, which focuses on brain atrophy, white matter and cortical lesions, and utilises both histology, ultra-high field and clinical MR, I have learnt to work with a variety of tools and software packages and became knowledgeable about the pathology of MS. My four PhD projects focus on: (1) The use of non-standardised, routine, clinical MRI in brain atrophy estimation; (2) The effect of grey matter lesions on cortical thickness; (3) STAR MS: a prospective study to evaluate the usefulness of the 'central vein sign' in patients with diagnostic uncertainty and (4) The central vein sign in MS and other disorders; a multi-centre MAGNIMS study. As part of my PhD, I have been able to work in collaborations with researchers from the UK and abroad.

My main research interests include quantitative MRI and how clinical MR images can be used for research purposes. I am especially interested in how we can utilise MRI to predict disease progression in MS patients.

Research Summary

I am a final year PhD student in the School of Psychology and the Division of Clinical Neuroscience. My PhD explores the hallmarks of MS including brain atrophy, white matter and cortical lesions. My… read more

Selected Publications

Current Research

I am a final year PhD student in the School of Psychology and the Division of Clinical Neuroscience. My PhD explores the hallmarks of MS including brain atrophy, white matter and cortical lesions. My four PhD projects focus on: (1) The use of non-standardised, routine, clinical MRI in brain atrophy estimation; (2) The effect of grey matter lesions on cortical thickness; (3) STAR MS: a prospective study to evaluate the usefulness of the 'central vein sign' in patients with diagnostic uncertainty and (4) The central vein sign in MS and other disorders; a multi-centre MAGNIMS study.

School of Psychology

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