1999-2002 PhD in Behavioural Neuroscience Laboratory of Behavioral Neurobiology. Swiss Federal Institute of Technology (ETH) Zürich. PhD program in neuroscience. University & ETH Neuroscience Center Zürich.
1996-1998 Equivalent of a M.S. in Neuroscience and Physiology, University Louis Pasteur, Strasbourg, France & University Laval, Québec, Canada
2013-2016 Research Fellow (research co-investigator on BBSRC grant) School of Psychology University of Nottingham
2009-2012 Leverhulme Trust Research Fellow School of Psychology University of Nottingham
2007-2009 Medical-Research-Scotland Research Fellow Centre for Cognitive and Neural Systems University of Edinburgh
2006 Research Fellow Astellas Institute for Neuroscience University of Edinburgh
2003- 2005 Marie-Curie Research Fellow Department of Experimental Psychology University of Cambridge
1999-2002 Pre-doctoral research assistant Lab of Behavioural Neurobiology Swiss Federal Institute of Technology (ETH) Zurich
Fronto-striatal mechanisms, dopamine, acetylcholine, cognition (attention and executive functions, memory, emotion), animal models, schizophrenia, Alzheimer.
I am interested in the brain mechanisms of cognition and behaviour in health and disorder. A focus of my research is on the brain mechanisms of memory, attention, response control and emotion and on… read more
PEZZE MA, MARSHALL HJ, FONE KC and CASSADAY HJ, 2017. Role of the anterior cingulate cortex in the retrieval of novel object recognition memory after a long delay. Learning & memory (Cold Spring Harbor, N.Y.). 24(7), 310-317 MCGARRITY S, MASON R, FONE KC, PEZZE M and BAST T, 2017. Hippocampal Neural Disinhibition Causes Attentional and Memory Deficits. Cerebral cortex (New York, N.Y. : 1991).
PEZZE, MARIE, MCGARRITY, STEPHANIE, MASON, ROB, FONE, KEVIN C. and BAST, TOBIAS, 2014. Too Little and Too Much: Hypoactivation and Disinhibition of Medial Prefrontal Cortex Cause Attentional Deficits JOURNAL OF NEUROSCIENCE. 34(23), 7931-7946
I am interested in the brain mechanisms of cognition and behaviour in health and disorder. A focus of my research is on the brain mechanisms of memory, attention, response control and emotion and on how dysfunction of these mechanisms contributes to cognitive impairments in disorders, including schizophrenia and age-related cognitive decline. To address these questions I am working with rodent models, where I combine translational behavioural tests (incl. five-choiceserial-reaction-task, classical fear conditioning, startle and PPI testing, water maze assays of spatial learning, spontaneous object recognition assay) with neurobiological methods (incl. neuropharmacological manipulations - systemic and via intracerebral microinfusions; lesions; in vivo microdialysis coupled with HPLC; neuroanatomy - routine stainings, tract tracing, immunohistochemistry; in vivo electrophysiology).
My current project focuses on hippocampal hyperexcitability and early early-stage behavioural and cognitive impairments in a rat model of Alzheimer's.