PhD Student - Behavioural Neuroscience, Faculty of Science
Too little and too much: impact of functional inhibition and disinhibition of the medial prefrontal cortex on cognitive flexibility assessed using an operant strategy-shifting task
Attentional performance requires balanced medial prefrontal cortex (mPFC) activity, with functional inhibition or disinhibition (by micro-infusion of GABA agonist muscimol or antagonist picrotoxin, respectively) causing impairments (Pezze et al., 2014, JNeurosci). Cognitive flexibility has also been suggested to require balanced mPFC activity (Brady & Floresco, 2016, JoVE). To confirm this, my research examines how mPFC muscimol and picrotoxin affect cognitive flexibility in Lister-hooded rats, using an operant strategy-shifting task involving shifts from egocentric-spatial to cue light-based responses or vice versa (Brady & Floresco, 2016).
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