Biomaterials Discovery

RC1: Moving from 2D to 3D Materials Discovery Methods


In this section of the project we are developing new methods to create material libraries for screening with 3D architectures, including particles and topographically patterned materials. Computational methods to take screening data and develop structure-property relationships are under development and being applied in this research challenge. A sound basis for the methods to be employed in the rest of the project has been laid. 

Video: Formation of acrylate droplets in a T-junction chip (10k fps)

Video: Formation of acrylate droplets in a flow focusing chip (20k fps) 

Future Focus:

Progressing from proof-of-principle experiments to ChemoTopo Chip samples will occur by verification of the prechip functionalisation route for a larger range of materials. The focus will then be on scale up of ChemoTopo Chip production with hit monomers from previous cell studies to be tested by other RCs.

For maximum production capacity, the microfluidics setup will be automated and parallelisation used. Polymeric surfactants are being investigated as alternatives to standard surfactants used to stabilise particles which is carried over into the particles. Deep Neural Network software will be developed to create more predictive models.

Next Generation Biomaterials Discovery

Advanced Materials and Healthcare Technologies, School of Pharmacy, The University of Nottingham
University Park
Nottingham, NG7 2RD

telephone: +44 (0) 115 846 6246