RC2: Systems Based Advanced Drug Delivery
This section of the project focuses on chemistries for new self-assembling delivery vehicles, and formulation of new particulates with enhanced drug compatibility using structure-informed nanoparticle libraries.This involves targeting and delivery for complex anti-cancer therapeutics, and innovative antimicrobials, including anti-virulence agents in dynamic controlled matrices for new anti-resistance therapies.
Polymers synthesised in RC2 have to date been tested for tolerability in a proposed cancer application, but these materials will be useful to other RCs. Drug delivery monomers already prepared are suitable for conjugation of multiple drugs for RC4 to create antimicrobial delivery systems. The degradable cross-linker synthesised can also be used in RC3 for degradable microparticles and in RC4 for degradable antimicrobials.
Future work will be on two main areas; the attachment of drugs to the current polymer libraries in RC1 (thus far we have used a model hydrophobic unit only), and the expansion of chemistries utilised in the polymer libraries to enable control of biodistribution, targeting and clearance. A second linker chemistry for both drug attachment and biodegradability will be explored further.
These chemistries will be incorporated into the same second generation polymer libraries already ongoing in RC1, in order to provide a diverse library of materials with different degradation profiles to address different biological requirements in RC2, 3 and 4.