Stephanie Lax

Contact

• workApplied Health Research Building
  University Park
  Nottingham
  NG7 2RD
  UK
• work0115 846 8631
• Stephanie.Lax@nottingham.ac.uk

Research Summary

My research priority has been a landmark Cochrane systematic review of topical corticosteroids in eczema, including 104 trials, and containing more detailed safety data than similar reviews. It is… read more

Recent Publications

• BENSON CS, SHAH A, STANWORTH SJ, FRISE CJ, SPIBY H, LAX SJ, MURRAY J and KLEIN AA, 2021. The effect of iron deficiency and anaemia on women’s health Anaesthesia. 76(Suppl 4), 84-95
• MUSTERS, AH, MASHAYEKHI, S, FLOHR, C, DRUCKER, AM, GERBENS, L, FERGUSON, J, IBBOTSON, S, DAWE, RS, GARRITSEN, F, BROUWER, M, LIMPENS, J, LAX, SJ, HARVEY, J, and SPULS, PI, 2021. Phototherapy for atopic eczema Cochrane Database of Systematic Reviews.
• WANG, SOPHIA S., CARRINGTON, MARY, BERNDT, SONJA I., SLAGER, SUSAN L., BRACCI, PAIGE M., VOUTSINAS, JENNA, CERHAN, JAMES R., SMEDBY, KARIN E., HJALGRIM, HENRIK, VIJAI, JOSEPH, MORTON, LINDSAY M., VERMEULEN, ROEL, PALTIEL, ORA, VAJDIC, CLAIRE M., LINET, MARTHA S., NIETERS, ALEXANDRA, DE SANJOSE, SILVIA, COZEN, WENDY, BROWN, ELIZABETH E., TURNER, JENNIFER, SPINELLI, JOHN J., ZHENG, TONGZHANG, BIRMANN, BRENDA M., FLOWERS, CHRISTOPHER R., BECKER, NIKOLAUS, HOLLY, ELIZABETH A., KANE, ELEANOR, WEISENBURGER, DENNIS, MAYNADIE, MARC, COCCO, PIERLUIGI, ALBANES, DEMETRIUS, WEINSTEIN, STEPHANIE J., TERAS, LAUREN R., DIVER, W. RYAN, LAX, STEPHANIE J., TRAVIS, RUTH C., KAAKS, RUDOLPH, RIBOLI, ELIO, BENAVENTE, YOLANDA, BRENNAN, PAUL, MCKAY, JAMES, DELFAU-LARUE, MARIE-HÉLÈNE, LINK, BRIAN K., MAGNANI, CORRADO, ENNAS, MARIA GRAZIA, LATTE, GIANCARLO, FELDMAN, ANDREW L., DOO, NICOLE WONG, GILES, GRAHAM G., SOUTHEY, MELISSA C., MILNE, ROGER L., OFFIT, KENNETH, MUSINSKY, JACOB, ARSLAN, ALAN A., PURDUE, MARK P., ADAMI, HANS-OLOV, MELBYE, MADS, GLIMELIUS, BENGT, CONDE, LUCIA, CAMP, NICOLA J., GLENN, MARTHA, CURTIN, KAREN, CLAVEL, JACQUELINE, MONNEREAU, ALAIN, COX, DAVID G., GHESQUIÈRES, HERVÉ, SALLES, GILLES, BOFETTA, PAULO, FORETOVA, LENKA, STAINES, ANTHONY, DAVIS, SCOTT, SEVERSON, RICHARD K., LAN, QING, BROOKS-WILSON, ANGELA, SMITH, MARTYN T., ROMAN, EVE, KRICKER, ANNE, ZHANG, YAWEI, KRAFT, PETER, CHANOCK, STEPHEN J., ROTHMAN, NATHANIEL, HARTGE, PATRICIA and SKIBOLA, CHRISTINE F., 2018. HLA Class I and II Diversity Contributes to the Etiologic Heterogeneity of Non-Hodgkin Lymphoma Subtypes Cancer Research. 78(14), 4086-4096
• SMITH A, CROUCH S, LAX SJ, LI J, PAINTER D, HOWELL D, PATMORE R, JACK A and ROMAN E, 2015. Lymphoma incidence, survival and prevalence 2004-2014: sub-type analyses from the UK's Haematological Malignancy Research Network British Journal of Cancer. 112(9), 1575-84

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Current Research

My research priority has been a landmark Cochrane systematic review of topical corticosteroids in eczema, including 104 trials, and containing more detailed safety data than similar reviews. It is part of the ECO project; a £2.4m NIHR Programme Grant for Applied Research to support self-care for eczema. I have also been part of the international team delivering a Cochrane review of phototherapy for atopic eczema and am currently working on a network meta-analysis of topical anti-inflammatory treatments for eczema.

In addition, I have been involved in a community engagement project to improve lay eczema knowledge and promote appropriate emollient and topical corticosteroid use, with professional orchestra Sinfonia Viva and Birmingham City University (BCU), funded by an NIHR Knowledge Mobilisation fellowship. The Dragon In My Skin book and film, with soundtrack developed during virtual workshops with children and families affected by eczema, premiered on 27th March 2021. A curriculum-linked resource pack for Key Stage 1 also accompanies the book and animation and has been distributed to around 800 schools in the Midlands.

Outside of CEBD, I am a service-user co-applicant on PANDA (Primary prevention of maternal ANaemia to avoid preterm delivery and other Adverse outcomes), an £2.4m NIHR Programme Grant.

Past Research

Whilst at the University of York, I was involved in the development of software for estimation of disease prevalence from incomplete longitudinal data: Crouch S, Lax SJ, Lacy SE. 'rprev: estimating disease prevalence from registry data', Comprehensive R Archive Network, first released 2nd September 2016. Details of how to obtain up-to-date code can be found here, with a user guide here.

Working towards my PhD at the University of Nottingham, I conducted a cross-sectional study of T helper cell subsets throughout the lifetime, employing clustering techniques to analyse multicolour flow cytometry datasets.

• BENSON CS, SHAH A, STANWORTH SJ, FRISE CJ, SPIBY H, LAX SJ, MURRAY J and KLEIN AA, 2021. The effect of iron deficiency and anaemia on women’s health Anaesthesia. 76(Suppl 4), 84-95
• MUSTERS, AH, MASHAYEKHI, S, FLOHR, C, DRUCKER, AM, GERBENS, L, FERGUSON, J, IBBOTSON, S, DAWE, RS, GARRITSEN, F, BROUWER, M, LIMPENS, J, LAX, SJ, HARVEY, J, and SPULS, PI, 2021. Phototherapy for atopic eczema Cochrane Database of Systematic Reviews.
• WANG, SOPHIA S., CARRINGTON, MARY, BERNDT, SONJA I., SLAGER, SUSAN L., BRACCI, PAIGE M., VOUTSINAS, JENNA, CERHAN, JAMES R., SMEDBY, KARIN E., HJALGRIM, HENRIK, VIJAI, JOSEPH, MORTON, LINDSAY M., VERMEULEN, ROEL, PALTIEL, ORA, VAJDIC, CLAIRE M., LINET, MARTHA S., NIETERS, ALEXANDRA, DE SANJOSE, SILVIA, COZEN, WENDY, BROWN, ELIZABETH E., TURNER, JENNIFER, SPINELLI, JOHN J., ZHENG, TONGZHANG, BIRMANN, BRENDA M., FLOWERS, CHRISTOPHER R., BECKER, NIKOLAUS, HOLLY, ELIZABETH A., KANE, ELEANOR, WEISENBURGER, DENNIS, MAYNADIE, MARC, COCCO, PIERLUIGI, ALBANES, DEMETRIUS, WEINSTEIN, STEPHANIE J., TERAS, LAUREN R., DIVER, W. RYAN, LAX, STEPHANIE J., TRAVIS, RUTH C., KAAKS, RUDOLPH, RIBOLI, ELIO, BENAVENTE, YOLANDA, BRENNAN, PAUL, MCKAY, JAMES, DELFAU-LARUE, MARIE-HÉLÈNE, LINK, BRIAN K., MAGNANI, CORRADO, ENNAS, MARIA GRAZIA, LATTE, GIANCARLO, FELDMAN, ANDREW L., DOO, NICOLE WONG, GILES, GRAHAM G., SOUTHEY, MELISSA C., MILNE, ROGER L., OFFIT, KENNETH, MUSINSKY, JACOB, ARSLAN, ALAN A., PURDUE, MARK P., ADAMI, HANS-OLOV, MELBYE, MADS, GLIMELIUS, BENGT, CONDE, LUCIA, CAMP, NICOLA J., GLENN, MARTHA, CURTIN, KAREN, CLAVEL, JACQUELINE, MONNEREAU, ALAIN, COX, DAVID G., GHESQUIÈRES, HERVÉ, SALLES, GILLES, BOFETTA, PAULO, FORETOVA, LENKA, STAINES, ANTHONY, DAVIS, SCOTT, SEVERSON, RICHARD K., LAN, QING, BROOKS-WILSON, ANGELA, SMITH, MARTYN T., ROMAN, EVE, KRICKER, ANNE, ZHANG, YAWEI, KRAFT, PETER, CHANOCK, STEPHEN J., ROTHMAN, NATHANIEL, HARTGE, PATRICIA and SKIBOLA, CHRISTINE F., 2018. HLA Class I and II Diversity Contributes to the Etiologic Heterogeneity of Non-Hodgkin Lymphoma Subtypes Cancer Research. 78(14), 4086-4096
• SMITH A, CROUCH S, LAX SJ, LI J, PAINTER D, HOWELL D, PATMORE R, JACK A and ROMAN E, 2015. Lymphoma incidence, survival and prevalence 2004-2014: sub-type analyses from the UK's Haematological Malignancy Research Network British Journal of Cancer. 112(9), 1575-84
• FRANKS, H.A., WANG, Q., LAX, S.J., COLLINS, M.K., ESCORS, D., PATEL, P.M. and JACKSON, A.M., 2014. Novel function for the p38-MK2 signalling pathway in circulating CD1c+ (BDCA-1+) myeloid dendritic cells from healthy donors and advanced cancer patients: inhibition of p38 enhances IL-12 whilst suppressing IL-10 International Journal of Cancer. 134(3), 575-586
• WANG Q, FRANKS HA, LAX S, EL REFAEE M, MALECKA A, SHAH S, SPENDLOVE I, GOUGH M, SEEDHOUSE C, SRINIVASAN M, PATEL PM and JACKSON AM, 2013. The Ataxia Telangiectasia Mutated Kinase pathway Regulates IL-23 Expression by Human Dendritic Cells: ATM regulates IL-23 in human DC Journal of Immunology. 190(7), (In Press.)