Assistant Professor, Faculty of Medicine & Health Sciences
Numerous bacterial pathogens employ specialized secretion systems to interact with and modify the host cellular environment. Our research is focused on the functional characterisation of two such… read more
Numerous bacterial pathogens employ specialized secretion systems to interact with and modify the host cellular environment. Our research is focused on the functional characterisation of two such secretion systems; the type III secretion system (T3SS) of the pediatric diarrheal pathogen enteropathogenic Escherichia coli (EPEC), and two functionally disparate type IV secretion systems (T4SS) of the gastric pathogen Helicobacter pylori. Working within the Centre for Biomolecular Sciences (CBS) building (http://www.nottingham.ac.uk/cbs/index.aspx), we use an extensive array of molecular and protein biochemical techniques, together with in vitro models of infection, epifluorescence microscopy and comprehensive bioinformatics analyses. Our main projects aim to dissect key stages in the host-pathogen interaction by characterisation of major bacterial virulence determinants which promote successful host colonisation and predispose towards disease.
Projects presently include:
Informal enquiries from overseas students regarding self-funded postgraduate (PhD) study within the group are welcome at any time.
The University of Nottingham
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Nottingham, NG7 2UH
telephone: +44 (0) 115 82 31090
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