Neuroscience at Nottingham
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Vincent Wilson

Associate Professor and Reader in Autonomic Pharmacology, Faculty of Medicine & Health Sciences

Contact

  • workRoom E34b The University of Nottingham Medical School
    Queen's Medical Centre
    Nottingham
    NG7 2UH
    UK
  • work0115 82 30189
  • fax0115 82 30142

Research Summary

Interests

  • The effect of dietary flavonoids and manipulation cellular cholesterol on vascular function
  • Autonomic neurotransmission in vascular and gastrointestinal muscle.
  • Bacterial products and the interaction between immune systems and the vasculature

Techniques

  • Isometric tension recording of large and small blood vessels (wire myography).
  • Radioligand binding and cyclic nucleotide measurements in smooth muscle.
  • Flow cytometry.

Projects

  • The effect of statins and manipulation of cellular cholesterol on smooth muscle, endothelial and nervous functionPharmacological strategies for treating faecal incontinence and haemorrhoids (Norgine and Pfizer, UK)
  • An integrated assessment of the ability of dietary flavonoids to improve vascular function (BBSRC)
  • Steroids and sepsis: Development of an in vitro human model to evaluate the effects of glucocorticoids on vascular reactivity (European Anaesthetic Society).

Centre Collaborators

  • Dr. William Dunn
  • Dr. Ravi Mahajan
  • Dr. Moira Taylor

UK Collaborators

  • Professor John Scholefield (Department of Surgery University of Nottingham).
  • Professor D, Pritchard (School of Pharmaceutical Sciences, University of Nottingham).
  • Dr David Hughes (BBSRC Insitute of Food Research, Colney Lane Norwich)

International Collaborators

  • Dr James Brock (Prince of Wales Medical Research Institute, Sydney, Austraila).

Recent Publications

  • DRAKE, T. M., 2018. Association between peri-operative angiotensin-converting enzyme inhibitors and angiotensin-2 receptor blockers and acute kidney injury in major elective non-cardiac surgery: a multicentre, prospective cohort study ANAESTHESIA. 73(10), 1214-1222
  • LOHSIRIWAT, VARUT, SCHOLEFIELD, JOHN H., WILSON, VINCENT G. and DASHWOOD, MICHAEL R., 2017. Endothelin-1 and its receptors on haemorrhoidal tissue: a potential site for therapeutic intervention BRITISH JOURNAL OF PHARMACOLOGY. 174(7), 569-579
  • BEED M, BRINDLEY PG, MAHAJAN R, JUTTNER I, CAMPION-SMITH J and WILSON VG, 2016. The association between prior statin use and long-term outcomes after critical care admission. Journal of critical care. 35, 63-8
  • RAYMENT SJ, SIMPSON JAD, EAMES T, ACHESON AG, DASHWOOD MR, HENRY Y, GRUSS H, SCHOLEFIELD JH and WILSON VG, 2014. Dual effects of α2 -adrenoceptors in modulating myogenic tone in sheep isolated internal anal sphincter. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. 26(8), 1095-103

Future Research

I have a long-standing interest in the pharmacological properties of isolated blood vessels, with particular interest in the factors that influence the functional expression of the receptors negatively-coupled to adenylyl cyclase and the activity of compounds of microbial origin.

Neuroscience at Nottingham

The University of Nottingham
Address line two
Nottingham, postcode


telephone: +44 (0) 115 XXX XXXX
email: research-group-email@nottingham.ac.uk