Physiology, Pharmacology and Neuroscience
 

Vincent Wilson

Associate Professor and Reader in Autonomic Pharmacology, Faculty of Medicine & Health Sciences

Contact

  • workRoom E34b The University of Nottingham Medical School
    Queen's Medical Centre
    Nottingham
    NG7 2UH
    UK
  • work0115 82 30189
  • fax0115 82 30142

Research Summary

Interests

  • The effect of dietary flavonoids and manipulation cellular cholesterol on vascular function
  • Autonomic neurotransmission in vascular and gastrointestinal muscle.
  • Bacterial products and the interaction between immune systems and the vasculature

Techniques

  • Isometric tension recording of large and small blood vessels (wire myography).
  • Radioligand binding and cyclic nucleotide measurements in smooth muscle.
  • Flow cytometry.

Projects

  • The effect of statins and manipulation of cellular cholesterol on smooth muscle, endothelial and nervous functionPharmacological strategies for treating faecal incontinence and haemorrhoids (Norgine and Pfizer, UK)
  • An integrated assessment of the ability of dietary flavonoids to improve vascular function (BBSRC)
  • Steroids and sepsis: Development of an in vitro human model to evaluate the effects of glucocorticoids on vascular reactivity (European Anaesthetic Society).

Centre Collaborators

  • Dr. William Dunn
  • Dr. Ravi Mahajan
  • Dr. Moira Taylor

UK Collaborators

  • Professor John Scholefield (Department of Surgery University of Nottingham).
  • Professor D, Pritchard (School of Pharmaceutical Sciences, University of Nottingham).
  • Dr David Hughes (BBSRC Insitute of Food Research, Colney Lane Norwich)

International Collaborators

  • Dr James Brock (Prince of Wales Medical Research Institute, Sydney, Austraila).

Recent Publications

  • DRAKE, T. M., 2018. Association between peri-operative angiotensin-converting enzyme inhibitors and angiotensin-2 receptor blockers and acute kidney injury in major elective non-cardiac surgery: a multicentre, prospective cohort study ANAESTHESIA. 73(10), 1214-1222
  • LOHSIRIWAT, VARUT, SCHOLEFIELD, JOHN H., WILSON, VINCENT G. and DASHWOOD, MICHAEL R., 2017. Endothelin-1 and its receptors on haemorrhoidal tissue: a potential site for therapeutic intervention BRITISH JOURNAL OF PHARMACOLOGY. 174(7), 569-579
  • BEED M, BRINDLEY PG, MAHAJAN R, JUTTNER I, CAMPION-SMITH J and WILSON VG, 2016. The association between prior statin use and long-term outcomes after critical care admission. Journal of critical care. 35, 63-8
  • RAYMENT SJ, SIMPSON JAD, EAMES T, ACHESON AG, DASHWOOD MR, HENRY Y, GRUSS H, SCHOLEFIELD JH and WILSON VG, 2014. Dual effects of α2 -adrenoceptors in modulating myogenic tone in sheep isolated internal anal sphincter. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. 26(8), 1095-103

Future Research

I have a long-standing interest in the pharmacological properties of isolated blood vessels, with particular interest in the factors that influence the functional expression of the receptors negatively-coupled to adenylyl cyclase and the activity of compounds of microbial origin.

Physiology, Pharmacology and Neuroscience

School of Life Sciences
University of Nottingham
Medical School
Queen's Medical Centre
Nottingham NG7 2UH