Speaker: Dr Po-Wah So ,Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience,Maurice Wohl Clinical Neuroscience Institute,King's College London
Title: 'Rusting with age'
Abstract- My Phenomics lab is investigating the role of iron and inflammation (and peripheral disease) in normal brain ageing and neurodegenerative disease using magnetic resonance imaging (MRI), nuclear magnetic resonance spectroscopy (NMR)-based metabolomics and X-ray fluorescence (XRF)-based elementomics/metallomics alongside behaviour, molecular biology and histology-based techniques.
Iron is essential for life but is detrimental in excess. Brain iron accumulation occurs in ageing, alongside neuroinflammation, and appears even greater in neurodegenerative disease such as Alzheimer’s Disease. Different modes of magnetic resonance imaging (MRI) are sensitive to iron with various specificities and sensitivities. I will show how MRI-R2- and -R2* correlates to in vitro iron measurements by synchrotron radiation-based XRF (SRXRF) of the same brain tissues. Additionally, I will show how regional brain R2 and R2* change with ageing in an experimental model and how these MRI measures relate to both SRXRF iron measures and ferritin immunohistochemistry. Also, I will present the effects of a robust ‘anti-brain ageing’ regimen on substantia nigra MRI-R2 in an experimental model.