Speaker : Dr Natalie Adams, Postdoctoral Researcher, Clinical Neurosciences, Cambridge University
Title : Towards a mechanistic understanding of cognitive deficits in frontotemporal dementia.
Abstract: Continuing developments in the modelling of non-invasive imaging data are bringing us closer to the goals of translational neuroscience. Using increasingly realistic biophysical models and the high temporal resolution of magnetic signals from the brain that MEG provides, we are now also incorporating information from other imaging modalities to enrich our models and provide insight into how pathology develops, mechanistically. This work focuses on frontotemporal dementia, which has a huge diversity of symptoms overlapping across different subsets of the disease. We demonstrate the facility for generative modelling to take us from the behavior of our participants right down to the local circuit synapse, bridging an understanding between these levels. And finally, by employing acute pharmacological intervention we can probe brain networks in the context of pathology-specific deficits to understand how drugs effects are manifested in functional networks.