I am an Assistant Professor in Bioinformatics at the Nottingham School of Veterinary Medicine and Science (since June, 2016). Previously, I was a research fellow at the Imperial College London (2011 - 2016). My research themes include the development of novel bioinformatics solutions to understand and diagnose infectious diseases in animals and humans. I have extensive experience with vector-borne diseases, in particular malaria and the reproductive biology of Anopheles. I obtained my Laurea Degree in Biological Sciences from the University of Perugia and a PhD degree in Structural Biology and Bioinformatics from the University of Rome Tor Vergata.
My current interests are in the development of original methods and algorithms to gain deeper insight in biological problems related to animal health and welfare and develop diagnostic tools. To this purpose in my research I try to merge different disciplines and knowledge/skills, including: supervised and unsupervised machine learning methods to develop predictive models and solve data mining tasks, in particular in scenarios involving large-data; analysis of -omics data including genomics (functional genomics, comparative genomics), proteomics (structural genomics, immunoproteomics), transcriptomics (RNA-seq, microarray), analysis of regulatory networks. I have extensive experience in structural biology using experimental approaches such as crystallography, and using bioinformatics, including: homology modelling, threading and ab initio. I work on 3D structure determination, protein-protein and protein-ligand docking analysis, comparative 3D structure analysis, interacting amino acid residues, clefts and cavities in proteins and predict biochemical function from the 3D structure. I am proficient in the analysis of next-generation sequencing (NGS) data including: quality control, mapping (genome guided and de novo assembly), and differential expression; post-processing analysis for the annotation, interpretation and identification of relevant profiles and/or patterns.
WALTON E, CASEY C, MITSCH J, VÁZQUEZ-DIOSDADO JA, YAN J, DOTTORINI T, ELLIS KA, WINTERLICH A and KALER J, 2018. Evaluation of sampling frequency, window size and sensor position for classification of sheep behaviour. Royal Society open science. 5(2), 171442 TIAN AL, LU M, CALDERÓN-MANTILLA G, PETSALAKI E, DOTTORINI T, TIAN X, WANG Y, HUANG SY, HOU JL, LI X, ELSHEIKHA HM and ZHU XQ, 2018. A recombinant Fasciola gigantica 14-3-3 epsilon protein (rFg14-3-3e) modulates various functions of goat peripheral blood mononuclear cells. Parasites & vectors. 11(1), 152
HALL, A. B., PAPATHANOS, P. A., SHARMA, A., CHENG, C., AKBARI, O. S., ASSOUR, L., BERGMAN, N. H., CAGNETTI, A., CRISANTI, A., DOTTORINI, T., FIORENTINI, E., GALIZI, R., HNATH, J., JIANG, X., KOREN, S., NOLAN, T., RADUNE, D., SHARAKHOVA, M. V., STEELE, A., TIMOSHEVSKIY, V. A., WINDBICHLER, N., ZHANG, S., HAHN, M. W., PHILLIPPY, A. M., EMRICH, S. J., SHARAKHOV, I. V., TU, Z. J. and BESANSKY, N. J., 2016. Radical remodeling of the Y chromosome in a recent radiation of malaria mosquitoes. Proc Natl Acad Sci U S A.