School of Veterinary Medicine and Science
   
   
  
 

Image of Tania Dottorini

Tania Dottorini

Assistant Professor in Bioinformatics, Faculty of Medicine & Health Sciences

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Biography

I am an Assistant Professor in Bioinformatics at the Nottingham School of Veterinary Medicine and Science (since June, 2016). Previously, I was a research fellow at the Imperial College London (2011 - 2016). My research themes include the development of novel bioinformatics solutions to understand and diagnose infectious diseases in animals and humans. I have extensive experience with vector-borne diseases, in particular malaria and the reproductive biology of Anopheles. I obtained my Laurea Degree in Biological Sciences from the University of Perugia and a PhD degree in Structural Biology and Bioinformatics from the University of Rome Tor Vergata.

Expertise Summary

My current interests are in the development of original methods and algorithms to gain deeper insight in biological problems related to animal health and welfare and develop diagnostic tools. To this purpose in my research I try to merge different disciplines and knowledge/skills, including: supervised and unsupervised machine learning methods to develop predictive models and solve data mining tasks, in particular in scenarios involving large-data; analysis of -omics data including genomics (functional genomics, comparative genomics), proteomics (structural genomics, immunoproteomics), transcriptomics (RNA-seq, microarray), analysis of regulatory networks. I have extensive experience in structural biology using experimental approaches such as crystallography, and using bioinformatics, including: homology modelling, threading and ab initio. I work on 3D structure determination, protein-protein and protein-ligand docking analysis, comparative 3D structure analysis, interacting amino acid residues, clefts and cavities in proteins and predict biochemical function from the 3D structure. I am proficient in the analysis of next-generation sequencing (NGS) data including: quality control, mapping (genome guided and de novo assembly), and differential expression; post-processing analysis for the annotation, interpretation and identification of relevant profiles and/or patterns.

Recent Publications

  • HALL, A. B., PAPATHANOS, P. A., SHARMA, A., CHENG, C., AKBARI, O. S., ASSOUR, L., BERGMAN, N. H., CAGNETTI, A., CRISANTI, A., DOTTORINI, T., FIORENTINI, E., GALIZI, R., HNATH, J., JIANG, X., KOREN, S., NOLAN, T., RADUNE, D., SHARAKHOVA, M. V., STEELE, A., TIMOSHEVSKIY, V. A., WINDBICHLER, N., ZHANG, S., HAHN, M. W., PHILLIPPY, A. M., EMRICH, S. J., SHARAKHOV, I. V., TU, Z. J. and BESANSKY, N. J., 2016. Radical remodeling of the Y chromosome in a recent radiation of malaria mosquitoes. Proc Natl Acad Sci U S A.
  • CANAVESE, M., DOTTORINI, T. and CRISANTI, A., 2015. VEGF and LPS synergistically silence inflammatory response to Plasmodium berghei infection and protect against cerebral malaria. Pathog Glob Health. 109(6), 255-65
  • NEAFSEY, D. E., WATERHOUSE, R. M., ABAI, M. R., AGANEZOV, S. S., ALEKSEYEV, M. A., ALLEN, J. E., AMON, J., ARCA, B., ARENSBURGER, P., ARTEMOV, G., ASSOUR, L. A., BASSERI, H., BERLIN, A., BIRREN, B. W., BLANDIN, S. A., BROCKMAN, A. I., BURKOT, T. R., BURT, A., CHAN, C. S., CHAUVE, C., CHIU, J. C., CHRISTENSEN, M., COSTANTINI, C., DAVIDSON, V. L., DELIGIANNI, E., DOTTORINI, T., DRITSOU, V., GABRIEL, S. B., GUELBEOGO, W. M., HALL, A. B., HAN, M. V., HLAING, T., HUGHES, D. S., JENKINS, A. M., JIANG, X., JUNGREIS, I., KAKANI, E. G., KAMALI, M., KEMPPAINEN, P., KENNEDY, R. C., KIRMITZOGLOU, I. K., KOEKEMOER, L. L., LABAN, N., LANGRIDGE, N., LAWNICZAK, M. K., LIRAKIS, M., LOBO, N. F., LOWY, E., MACCALLUM, R. M., MAO, C., MASLEN, G., MBOGO, C., MCCARTHY, J., MICHEL, K., MITCHELL, S. N., MOORE, W., MURPHY, K. A., NAUMENKO, A. N., NOLAN, T., NOVOA, E. M., O'LOUGHLIN, S., ORINGANJE, C., OSHAGHI, M. A., PAKPOUR, N., PAPATHANOS, P. A., PEERY, A. N., POVELONES, M., PRAKASH, A., PRICE, D. P., RAJARAMAN, A., REIMER, L. J., RINKER, D. C., ROKAS, A., RUSSELL, T. L., SAGNON, N., SHARAKHOVA, M. V., SHEA, T., SIMAO, F. A., SIMARD, F., SLOTMAN, M. A., SOMBOON, P., STEGNIY, V., STRUCHINER, C. J., THOMAS, G. W., TOJO, M., TOPALIS, P., TUBIO, J. M., UNGER, M. F., VONTAS, J., WALTON, C., WILDING, C. S., WILLIS, J. H., WU, Y. C., YAN, G., ZDOBNOV, E. M., ZHOU, X., CATTERUCCIA, F., CHRISTOPHIDES, G. K., COLLINS, F. H., CORNMAN, R. S., CRISANTI, A., DONNELLY, M. J., EMRICH, S. J., FONTAINE, M. C., GELBART, W., HAHN, M. W., HANSEN, I. A., HOWELL, P. I., KAFATOS, F. C., KELLIS, M., LAWSON, D., LOUIS, C., LUCKHART, S., MUSKAVITCH, M. A., RIBEIRO, J. M., RIEHLE, M. A., SHARAKHOV, I. V., TU, Z., ZWIEBEL, L. J. and BESANSKY, N. J., 2015. Mosquito genomics. Highly evolvable malaria vectors: the genomes of 16 Anopheles mosquitoes. Science. 347(6217), 1258522
  • DOTTORINI, T., PERSAMPIERI, T., PALLADINO, P., BAKER, D. A., SPACCAPELO, R., SENIN, N. and CRISANTI, A., 2013. Regulation of Anopheles gambiae male accessory gland genes influences postmating response in female. FASEB J. 27(1), 86-97

School of Veterinary Medicine and Science

University of Nottingham
Sutton Bonington Campus
Leicestershire, LE12 5RD

telephone: +44 (0)115 951 6116
fax: +44 (0)115 951 6415
email: veterinary-enquiries@nottingham.ac.uk