Pages 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 207 208 209 210 211 212 213 214 215 216 217 218 219 220 221 222 223 224 225 226 227 228 229 230 231 232 233 234 235 236 237 238 239 240 241 242 243 244 245 246 247 248 249 250 251 252 253 254 255 256 257 258 259 260 261 262 263 264 265 266 267 268 269 270 271 272 273 274 275 276 277 278 279 280 281 282 283 284 285 286 287 288 289 290 291 292 293 294 295 296 297 298 299 300 301 302 303 304 305 306 307 308 309 310 311 312 313 314 315 316 317 318 319 320 321 322 323 324 325 326 327 328 329 330 331 332 333 334 335 336 337 338 339 340 341 342 343 344 345 346 347 348 349 350 351 352 353 354 355 356 357 358 359 360 361 362 363 364 365 366 367 368 369 370 371 372 373 374 375 376 377 378 379 380 381 382 383 384 385 386 387 388 389 390 391 392 393 394 395 396 397 398 399 400 401 402 403 404 405 406 407 408 409 410 411 412 413 414 415 416 417 418 419 420 421 422 423 424 425 426 427 428 429 430 431 432 433 434 435 436 437 438 439 440 441 442 443 444 445 446 447 448 449 450 451 452 453 454 455 456 457 458 459 460 461 462 463 464 465 466 467 468 469 470 471 472 473 474 475 476 477 478 479 480 481 482 483 484 485 486 487 488 489 490 491 492 9827 result(s) returned

7.6 Who should estimate?

The person managing the project is not necessarily the best one to prepare the estimates, although they should be closely involved, both as a source of information and because they need a clear understanding of what the estimates mean and what the estimators assume about outputs, inputs and the transformation process. If there are others who have more experience or more knowledge about some of the areas of work, these people may be the best ones to make estimates for the project or parts of i
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Community Discussion on Open Sharing and OpenCourseWare
Who could have guessed that a Florentine omelet played a role in the origins of the OpenCourseWare initiative? A breakfast meeting in a New York “greasy spoon” was one of the seminal moments shaping OCW, according to William G. Bowen, who dined with Charles Vest and discussed Mellon Foundation support for the initiative. Bowen prais
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2.5 Summary
In this unit you will learn how advances in genetics could change the way in which diseases are diagnosed and managed. The advent of predictive medicine, based on more detailed DNA profiling of individual genotypes using technologies like gene chips, rather than screening for one gene at a time, may shift the relationship between doctor and patient. People will be seeking advice on how to manage their susceptibilities or genetic risks, rather than looking for treatment for an already existing di
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2.4 Current UK provision
In this unit you will learn how advances in genetics could change the way in which diseases are diagnosed and managed. The advent of predictive medicine, based on more detailed DNA profiling of individual genotypes using technologies like gene chips, rather than screening for one gene at a time, may shift the relationship between doctor and patient. People will be seeking advice on how to manage their susceptibilities or genetic risks, rather than looking for treatment for an already existing di
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2.2.4 Longer-term considerations
In this unit you will learn how advances in genetics could change the way in which diseases are diagnosed and managed. The advent of predictive medicine, based on more detailed DNA profiling of individual genotypes using technologies like gene chips, rather than screening for one gene at a time, may shift the relationship between doctor and patient. People will be seeking advice on how to manage their susceptibilities or genetic risks, rather than looking for treatment for an already existing di
Author(s): The Open University

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2.2.3 Cystic fibrosis
In this unit you will learn how advances in genetics could change the way in which diseases are diagnosed and managed. The advent of predictive medicine, based on more detailed DNA profiling of individual genotypes using technologies like gene chips, rather than screening for one gene at a time, may shift the relationship between doctor and patient. People will be seeking advice on how to manage their susceptibilities or genetic risks, rather than looking for treatment for an already existing di
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2.2.1 Phenylketonuria
In this unit you will learn how advances in genetics could change the way in which diseases are diagnosed and managed. The advent of predictive medicine, based on more detailed DNA profiling of individual genotypes using technologies like gene chips, rather than screening for one gene at a time, may shift the relationship between doctor and patient. People will be seeking advice on how to manage their susceptibilities or genetic risks, rather than looking for treatment for an already existing di
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2.2 Population screening for genetic disease: the precedents
In this unit you will learn how advances in genetics could change the way in which diseases are diagnosed and managed. The advent of predictive medicine, based on more detailed DNA profiling of individual genotypes using technologies like gene chips, rather than screening for one gene at a time, may shift the relationship between doctor and patient. People will be seeking advice on how to manage their susceptibilities or genetic risks, rather than looking for treatment for an already existing di
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2.1 Predictive medicine?
In this unit you will learn how advances in genetics could change the way in which diseases are diagnosed and managed. The advent of predictive medicine, based on more detailed DNA profiling of individual genotypes using technologies like gene chips, rather than screening for one gene at a time, may shift the relationship between doctor and patient. People will be seeking advice on how to manage their susceptibilities or genetic risks, rather than looking for treatment for an already existing di
Author(s): The Open University

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1.1 What is the future of healthcare?
In this unit you will learn how advances in genetics could change the way in which diseases are diagnosed and managed. The advent of predictive medicine, based on more detailed DNA profiling of individual genotypes using technologies like gene chips, rather than screening for one gene at a time, may shift the relationship between doctor and patient. People will be seeking advice on how to manage their susceptibilities or genetic risks, rather than looking for treatment for an already existing di
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3.1 Protein diversity

Of course, our bodies can't just be made up of squidgy bubbles of phospholipid, or we would collapse in a heap on the floor! Stiffer frameworks, both inside and outside the cells, also exist and help to define shape and add strength. These frameworks are formed largely from structural proteins, a class of polymeric materials that form fibres and filaments to provide mechanical support for cells and tissues. Structural proteins are made inside cells but are often then moved into the spa
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2 Construction with lipids

The cell membrane is constructed from lipids. Chemically, lipids are a rather varied group of compounds that include all the substances you might already think of as fats or oils. What they have in common is that they are all insoluble in polar liquids like water, but soluble in organic (carbon-based) solvents: by this I mean the sort of smelly solvents you tend to find in paints, glues and degreasing agents; chloroform is one example. Lipids make up the fatty components of living organisms a
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8 Drawing up the implementation plan

Once the detailed planning and risk assessments have been carried out, you are ready to assemble your implementation plan. A typical implementation plan, including diagrams and charts where appropriate, will contain:

  • a description of the background to the project;

  • its goals and objectives in terms of intended outputs and/or outcomes;

  • the resource implications (budget, personnel – including any training requirements
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3.2 The project plan

Although there are many approaches to planning a project, there are seven elements that are normally included in a project plan:

  • a work breakdown structure to show separate tasks and activities;

  • the team structure and responsibilities of key people;

  • an estimate of effort and duration for each task;

  • a schedule to show the sequence and timing of activities;

  • details of resources to be al
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4.3.2 Network externalities and increasing returns to scale

The reader should ask herself the following question: Would I subscribe to a telephone service knowing that nobody else subscribes to a telephone service?

The answer should be: Of course not! What use will anyone have from having a telephone when there is no one to talk to?

(Shy, 2001, p. 3)

The uncertainty surrounding production in the introductory phase, which places such importance on
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3.5 Centre for studies on inclusive education (CSIE)

In an English context, the influence of the Salamanca Statement can be seen in the work of the Centre for Studies on Inclusive Education (CSIE), which defines inclusive education as principally a human rights issue. CSIE's manifesto, Ten Reasons for Inclusion, states in its headline that ‘Inclusive education is a human right, it's good education and it makes good social sense’ (CSIE, 2004a). The manifesto then expands on the ‘human rights’ issue by providing a
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Leading Innovation
Since innovation is “not necessarily always predictable,” Daniel Vasella declines to discuss it in a systematic way, and instead, focuses on a case study of one of his company’s flagship pharmaceuticals, Gleevec. The discovery, development and marketing of this drug, which fights the rare chronic myeloid leukemia (CM
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The Phenology Handbook
A guide to phenological monitoring for students, teachers, families, and nature enthusiasts. Phenology is the observation and measurement of events in time. The passing of the seasons is one of the most familiar phenomena on Earth. Consider, for example, the onset of spring in temperate climates. As winter ends, our surroundings burst with new life — forest canopies fill with vibrant greens, flocks of birds migrate in formation to northern breeding grounds, and brilliant wildflowers and their
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Nucleic acids and chromatin
This unit helps you understand the properties of nucleotides and how they contribute to secondary and tertiary structures of nucleic acids at the molecular level. You will learn about the different composition and roles of nucleic acids in the cell, their interactions with each other and the use of ribozymes, aptamers, antisense and hybridization as tools in molecular research. The unit covers the function of DNA packaging within the cell, the interactions between the DNA double helix and the nu
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Globalization of Science: Opportunities for Competitive Advantage from Science in China, India and B
When Fiona Murray visited research centers in China recently, scientists greeted her quizzically: “People were baffled about what a business school professor was doing in stem cell and gene sequencing labs,” Murray says.

As it turns out, Murray’s tour was integral to her own MIT Sloan research exploring how

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