2.4 Receptor inactivation As with all signalling components, receptors need to be switched off as well as on. Receptor inactivation can operate in several ways including removal of the ligand by degradation or sequestration, and desensitization of the target cell. Binding of a ligand to its receptor is a reversible process, as the ligand will ultimately dissociate from the receptor and may be degraded. Acetylcholine is a good example of a signal regulated in this way; it is degraded by the enzyme cholinesterase
Models of Design Requirement
Case studies show that significant proportions of design errors and failures are linked to poor requirement specification during both early stages of design and as changes occur. Computational requirements engineering as a front-end to design iterations is a promising area addressing theseproblems. In other design disciplines, such as in software engineering, requirement engineering has given significant product improvements. In this paper, we present a state-space representation of requirement
Leafy Spurge Weed Invasion
This video segment from Evolution: "Extinction!" explores the invasion of western U.S. grasslands by a Eurasian weed called leafy spurge. Brought to this country in the 1800s, leafy spurge has progressively taken over grazing land from the native grasses. Ranchers have begun to eradicate the weed, using one of its natural enemies: the flea beetle. Closed captioning included. Run time 04:44.
1.2 Nucleic acids: genetic, functional and structural roles in the cell The first role that one immediately thinks about for nucleic acids is that of an inherited genetic material, principally in the form of DNA. In some cases, the inherited genetic material is RNA instead of DNA. For example, almost 60% of all characterised viruses have RNA genomes and these are more common in plant viruses than in animal viruses. There is considerable variation in the amount of genetic material present within organisms (Author(s):
All About Your Body! | Human Body Compilation
The human body is a complicated thing! To be able to move, fight off diseases, and even see colors, lots of different systems and organs need to work together. Squeaks' robot body is pretty complicated, too, so Jessi has put together a bunch of videos about your body as she makes sure he's in tip-top shape! (15:11)
Literary Festival 2016: United Nations on Trial [Audio]
Speaker(s): The Hon. Mr Justice Jay, Gráinne Mellon, Professor Gerry Simpson, Paul Clark, Natalie Samarasinghe, Dr Nazila Ghanea, Professor Francoise Hampson, Antony Loewenstein, Carne Ross | The Charter of the United Nations, drafted in 1945, pledged in the name of the peoples of the United Nations to save us from the scourge of war; to reaffirm faith in human rights and the dignity and worth of all; to promote social progress and better standards of life in conditions of freedom. One does not
6.4 Case history: the Topper boat Replacement of one polymeric material by another may be undertaken entirely for manufacturing reasons, and this is what happened in the redesign of the Topper dinghy for thermoplastic polymer. The dinghy was originally designed for hand lay-up GRP in 1969 by Ian Proctor, a well known designer of small boats and yachts (Figure 61
4 Introduction (Please refer to Reading 4: Learning to act: managing and systems practice, by Andy Lane) This course teaches some aspects of systems thinking and practice. But what does it mean to be a systems practitioner, and is it different to being a manager? This reading attempts to answer those questions. First, I believe a good systems practitioner will be more competent at handling complex situations, more capable of managing their working and domestic lives, and more able to learn not only ho
John Adams and the Boston Massacre
Fame without Honor is the key phrase in this interesting look at John Adams as done by an actor using the president's writings to show how he acted and why. Very good, but this 4:38 video is best used to show the times and the nature of Adams.
4.2 Social dynamics Yet another type of diagram is given in this section. Take a preliminary look at Figure 7, which is a way of illustrating the relationshi 3.4 Converting units by using a formula It is sometimes necessary to convert from one unit of measurement to another. You can use a formula in order to do this. Use the formula 1 pint = 0.5683 litres (to 4 s.f.) to calculate the number of litres in 8 pints (or 1 gallon). Give your answer to 3 significant 1 Why is information security important? This course introduces you to information security and its management. A succinct definition of information security might run as follows: Information security is the collection of technologies, standards, policies and management practices that are applied to information to keep it secure. But why is it important to secure information? And how should its security be managed? To SP.769 Photovoltaic Solar Energy Systems (MIT) Inside Cancer 2.2 The classic six-stage project management model This model also consists of stages, but, unlike the sequential flow of the project life-cycle, the six-stage model assumes that some stages are carried out simultaneously. In particular, the model (Figure 3) assumes that communications will take place throughout the project. It also assumes that team building, leading and motivatio Suffer the children as schoolhouse hit in Aleppo Summary of Section 2 Nucleic acids are intrinsically highly flexible molecules. The chemical properties of nucleic acid components are primary determinants in structure formation. The formation of nucleic acid structures is driven by base pairing and stacking interactions between the hydrophobic bases. In DNA, these interactions drive the formation of the double helix, whose structure is maintained under torsional stress by twisting. RNA second 2.4 Analysis of nucleic acids by electrophoresis and hybridisation Nucleic acids can be separated according to size by gel electrophoresis, most commonly performed using a horizontal gel (Figure 7a). This is in contrast to the vertical gel electrophoresis set-up, which is generally used for analysis of proteins. The size of DNA molecules is usually expressed in terms of the number of 3.2 Trimeric G proteins G proteins are attached to the cytosolic face of the plasma membrane, where they serve as relay proteins between the receptors and their target signalling proteins. Trimeric G proteins interact with 7TM receptors and are all heterotrimeric, having structurally different α, β and γ subunits. Monomeric G proteins are the small G proteins, such as Ras, which are structurally related to the α subunit of trimeric G proteins. The three-dimensional structure of trimeric G proteins in Onderzoekend leren : Case Based Learning Deze website omvat multimediacases (videobeelden en reflectietaken) om analyse en discussie op gang te trekken in de didactiek van onderzoekend leren. Iedere case kenmerkt een gelijkaardige structuur:
Example 11
This class will study the behavior of photovoltaic solar energy systems, focusing on the behavior of "stand-alone" systems. The design of stand-alone photovoltaic systems will be covered. This will include estimation of costs and benefits, taking into account any available government subsidies. Introduction to the hardware elements and their behavior will be included.
Dr Momna Hejmadi, Dr Andrew Chalmers and Dr Lorenzo Caggiano summarise some of the latest developments in cancer research. This lecture was delivered as part of our MOOC (Massive Open Online Course), 'Inside Cancer: how genes influence cancer development'. https://www.futurelearn.com/courses/inside-cancer
A schoolhouse is hit in Aleppo as President Bashar al-Assad's forces make gains outside Damascus. Deborah Lutterbeck reports.
Subscribe: http://smarturl.it/reuterssubscribe
More updates and breaking news: http://smarturl.it/BreakingNews
Reuters tells the world's stories like no one else. As the largest international multimedia news provider, Reuters provides coverage around the globe and across topics including business, financial, national, and international news. For over 160 years, Reuters
