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INN Placement Website
This artefact outlines the creation of a new website for Innovation North students holding details of all work placements (short, long term, voluntary, paid).The Institute for Enterprise funded the project and the money helped pay a student to maintain the website for a year
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King Collection - The Unfinished Work - Martin Luther King, Jr. Part Two
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Why Take A Language at GCSE
Why Take A Language at GCSE.
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Chair for Afternoon Session

Li-Huei Tsai, recorded 12/5/12


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DNA topoisomerases

Topoisomerases create temporary strand breaks in DNA, thereby allowing the DNA to ‘swivel’ around the helical axis and releasing torsional strain within the area before resealing the break. With the cellular DNA in a supercoiled state, topoisomerases play a critical role in regulating both how tightly packed DNA is within the cell and the dynamic state of torsional energies during DNA processing. There are two classes of this enzyme: topoisomerase I (topo I) functions by breaking just one
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2.3 Global power demand

In Section 2.2 we calculated a value of 14.3 TW for the average global requirement for primary power in 2002
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10 Risk assessment exercise

After reading this unit you might like to carry out a risk assessment of your office environment or a nearby office and one of the following:

  1. a display-screen user risk assessment;

  2. a laboratory-based risk assessment;

  3. a field-work risk assessment for a proposed field expedition.


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3.4.4 Sediment filling

The lifetime of reservoirs can vary greatly. Many reservoirs have lasted for over a hundred years, but some may be useful for only a much shorter period—fifty years or so — not because of the general deterioration of the dam as it gets older, but because sediment accumulates in the reservoir. Rivers carry large amounts of mud, silt and sand in suspension, particularly during floods, and when a river enters a reservoir it slows down and the sediment carried in suspension is deposited on th
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1 Water underground

Many people have the impression that underground water occupies vast caverns, such as those in the Derbyshire Peak District, flowing from one cavern to another along underground rivers. This is a common misconception: underground caverns are fairly rare, but huge quantities of water exist underground, within rocks. This is because many rocks contain pores, spaces that come in all shapes and sizes. In sediments, and consequently sedimentary rocks, there are often pores between gr
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1.1 Introduction

There are many environmental reasons why coal is a rather undesirable source of energy. Burning it introduces large amounts of gases into the atmosphere that harm the environment in a variety of ways, as well as other, solid waste products. Coal extraction leads to spoil heaps and mines that scar the landscape, land subsidence that affects roads and buildings, and in some cases water pollution.

With apparently so little going for it, why do we rely so much on coal to meet our energy nee
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Learning outcomes

By the end of this unit you should be able to:

  • explain how coal is formed;

  • explain how coal is found and extracted by either surface or underground mines;

  • discuss how geological problems and environmental issues surrounding extraction affect mining;

  • explain the reasons for the decline in the UK’s coal industry.


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4.5 Summary

  1. Targeting sequences at the N-terminus of proteins direct translation across the ER, and act as signals for import to the nucleus, mitochondrion and chloroplasts. Sequences at the C-terminus control traffic through the ER and the Golgi and to peroxisomes.

  2. Glycosylation is directed by signal sequences that act as targets for N-linked glycosylation in the ER and O-linked glycosylation in the Golgi apparatus. Glycosylation and remodelling of polys
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2.5 The endocytic pathways and lysosomes

Endocytosis is the process by which cells internalise molecules from the outside, and it includes pinocytosis, the uptake of small soluble molecules in vesicles, and phagocytosis, the internalisation of large insoluble particles. These are two ends of a spectrum as seen microscopically, but the receptors, the subsequent intracellular trafficking pathways and the fate of the internalised molecules, vary depending on the cell type and its functions. The endocytic pathway co
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3.2 Trimeric G proteins

G proteins are attached to the cytosolic face of the plasma membrane, where they serve as relay proteins between the receptors and their target signalling proteins.

Trimeric G proteins interact with 7TM receptors and are all heterotrimeric, having structurally different α, β and γ subunits. Monomeric G proteins are the small G proteins, such as Ras, which are structurally related to the α subunit of trimeric G proteins.

The three-dimensional structure of trimeric G proteins in
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5.1 Introduction

There are several types of diabetes, including two that are common: Type 1 and Type 2. Type 2 is the most common sort of diabetes. Worldwide, about 90 per cent of people with diabetes have Type 2 and about 10 per cent have Type 1. The other sorts of diabetes account for very small numbers of people.


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10 Managing the BSE/vCJD episode from March 1996

In March 1996, SEAC announced that the CJD Surveillance Unit had identified vCJD as a new human disease, the first death from which occurred in May 1995. SEAC concluded that, although there was no direct evidence of a link, the most likely explanation for vCJD was exposure to BSE before the SBO ban was introduced in 1989. At the time, the strongest evidence for the link was that vCJD was a new TSE in humans (the symptoms of which differed from previously known human TSEs) that had aris
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1.5.7 The signed area under a general velocity–time graph

We have already seen (in Section 3.6) that in the context of uniform motion, the signed area under a particle's velocity–time graph, between two given times, represents the change in the particle's position during that time interval, with a positive area corresponding to displacement in the positive direction. In the
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1.5.3 A note on functions and derivatives

This subsection introduces two crucially important mathematical ideas, functions and derivatives, both of which are used throughout physics.


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1.4.4 The equations of uniform motion

It has already been said that the straight-line graph of any uniform motion can be represented by an equation of the general form

where A and B are constants. Different cases of uniform motion simply correspond to different values for the constants A<
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1.4.3 Initial position and the intercept of the position–time graph

The uniform motion of a particle is such a simple form of motion that apart from enquiring about the particle's velocity, the only other kinematic question you can ask is ‘where was the particle at some particular time?’ The most common way of answering this question is to specify the initial position of the particle, that is, its position at time t = 0 s.

Although it is common to refer to the position at t = 0 as the ‘initial position’ it is also possib
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