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The seAFOod Trial
Leeds University
Leeds Insitute of Molecular Medicine

Systematic Evaluation of Aspirin and Fish Oil Bowel Polyp Prevention Trial

Welcome to the seAFOod Trial website

The seAFOod Polyp Prevention Trial is a large multi-centre trial being conducted in conjunction with the national Bowel Cancer Screening Programme in hospitals in England. The aim is to find out if an omega-3 fatty acid called EPA found naturally in fish oil, on its own or in combination with aspirin, can prevent the development of bowel polyps, which are small growths on the bowel lining.

The standard treatment to identify and remove bowel polyps is a colonoscopy, a camera test of the large bowel. The removal of bowel polyps reduces future bowel cancer risk but it is not 100% effective at preventing bowel cancer. That is why we want to find a more effective way to reduce bowel polyps and so reduce future bowel cancer risk.

One option is to treat patients with drugs or food supplements (this is called chemoprevention) after bowel polyps have been removed. We hope that this type of treatment may reduce the number of colonoscopies needed, and may even remove the need for repeat colonoscopy in some patients.

The trial is funded by the Efficacy and Mechanism Evaluation Programme (EME) which is funded by the Medical Research Council (MRC) and the National Institute for Health Research (NIHR), which is part of the NHS.

The Trial, which opened to recruitment in October 2011, has now closed to recruitment with a total of 709 participants. The Trial has 1 year left to follow up current participants and collect data, to be analysed and published.

Last updated : Monday, June 20, 2016 3:18 PM