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The seAFOod Trial
Leeds University
Leeds Insitute of Molecular Medicine

Systematic Evaluation of Aspirin and Fish Oil Bowel Polyp Prevention Trial

About the Trial

The seAFOod Polyp Prevention Trial was a large multi-centre trial being conducted in conjunction with the national Bowel Cancer Screening Programme in hospitals in England. The aim was to find out if an omega-3 fatty acid called EPA found naturally in fish oil, on its own or in combination with aspirin, can prevent the development of bowel polyps, which are small growths on the bowel lining. A proportion (estimated to be 1 in 20) of these polyps may turn into bowel (colon) cancer over a 5-10 year period. If we can prevent growth of these polyps we can reduce the chance of developing bowel cancer in the future.

The trial was funded by the Efficacy and Mechanism Evaluation (EME) Programme, a Medical Research Council (MRC) UK and National Institute for Health Research (NIHR) partnership (Project 09/100/25).

Trial Update - September 2018

The trial was opened to recruitment in October 2011 and closed to recruitment in June 2016 with the last follow-up visit carried out in June 2017. In total 709 participants took part in the trial.

We are currently in the process of writing the final report and preparing to publish our findings in a peer reviewed scientific journal. Links to all publications will be provided on this website as soon as they become available. Watch this space. We have also been in contact with sites about archiving and the close-out process, if you have not yet heard from us, please get in touch by emailing

We would like to thank everyone who has been involved in the trial over the years, we couldn't have done it without all of your help.

The seAFOod Team

Trial Update - November 2018

Trial Publication
We are very proud to announce the results have been published in one of the world’s leading scientific journals, The Lancet, and it is now a pleasure to be able to share the findings with you. Please find the links to the Lancet Paper and the NIHR Journal Entry below or check the Publications and Related Articles section of the website.

NIHR Journal Entry
The Lancet Paper

Participant Results Summary
If you took part in the trial, a summary of the results can be found here.

Last updated : Friday, September 7, 2018 12:28 PM