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Reusable Learning Object

Understanding First Pass Metabolism This RLO uses sound.

Drug Absorption

The drug is absorbed from the GI tract and passes via the portal vein into the liver where some drugs are metabolised. Sometimes the result of first pass metabolism means that only a proportion of the drug reaches the circulation.

First pass metabolism can occur in the gut and the liver. For example, first pass metabolism occurs in the gut for benzylpenicillin and insulin and in the liver for propranolol, lignocane, chloromethiasole and GTN.

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© 2004 School of Nursing, Midwifery and Physiotherapy,
University of Nottingham.

Content Author: Fiona Bath-Hextall
Developer: Fred Riley
RLO Released: 9 January, 2004
This page updated: 16 October, 2013 1:09 PM