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Understanding First Pass Metabolism This RLO uses sound.

Bypassing First Pass Metabolism

Two ways to bypass first pass metabolism involve giving the drug by sublingual and buccal routes.

The drugs are absorbed by the oral mucosa in both methods. In sublingual administration the drug is put under the tongue where it dissolves in salivary secretions. Nitroglycerine is administered in this way.

In buccal administration the drug is placed between the teeth and the mucous membrane of the cheek. Sublingual and buccal methods both avoid destruction by the GI fluids and first pass effect of the liver

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© 2004 School of Nursing, Midwifery and Physiotherapy,
University of Nottingham.

Content Author: Fiona Bath-Hextall
Developer: Fred Riley
RLO Released: 9 January, 2004
This page updated: 19 August, 2004 1:16 PM