The hepatic portal vein and hepatic artery deliver oxygen and nutrients into the blood sinusoids. This close relationship between the hepatocytes and surrounding blood enables many metabolic processes to take place.
Blood flows out of the sinusoids into the central vein, removing detoxified substances and metabolic end products. The central vein ultimately reunites with the hepatic vein transporting these substances out of the liver.
Bile that is produced by the hepatocytes drains into tiny canals called bile canaliculi (singular canaliculus). These drain into bile ducts located around the lobule perimeter.