Nottingham Research Fellow, Faculty of Medicine & Health Sciences
Toshana received her Wellcome Trust PhD from the Astbury Centre for Structural Molecular Biology at the University of Leeds in 2011. Her graduate studies focussed on the structural, biochemical and functional characterisation of hepatitis C virus (HCV) proteins in the laboratories of Professor Mark Harris, Dr Stephen Griffin and Professor Arwen Pearson. The aim was to elucidate fundamental questions about the structure-function relationships of three HCV proteins: NS2-3, p7 and NS5A. Subsequently, she worked on defining the structure of the viroporin p7 and solved one of the first structures of the monomeric protein by solution NMR methods that has been used to rationally design inhibitors of the p7 channel activity.
Toshana then moved to King's College London for her postdoctoral studies in Professor Stuart Neil's laboratory. There she worked on the molecular and cell biology of HIV-1 Vpu and led the studies into the role of interferon induced transmembrane (IFITM) proteins in restricting HIV-1 and the contribution of envelope conformation, as well as the engagement with CD4, on IFITM sensitivity and by inference on HIV-1 envelope entry pathways.
In April 2018, Toshana joined the One Virology Group within the School of Veterinary Medicine and Science as a Nottingham Research Fellow.
Research in the group will focus on understanding the molecular pathways and mechanisms that emerging viruses such as the Arenaviridae, exploit to establish infection and will investigate how they… read more
Research in the group will focus on understanding the molecular pathways and mechanisms that emerging viruses such as the Arenaviridae, exploit to establish infection and will investigate how they circumvent the host innate immune response in order to cross the species barrier.
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