Centre of Evidence Based Dermatology
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Systematic reviews on eczema

Do you struggle to find the latest evidence about major skin disorders and their treatments? If so, our maps of systematic reviews are for you.

This page is a mapping by topic of systematic reviews on eczema (atopic eczema) published since the 2000 HTA Systematic review of treatments for atopic eczema. The systematic reviews were found in the searches for our Annual Evidence Updates and CEBD Evidence Updates. Links are given to the PubMed abstract, or the original publication if not in PubMed.

It is important to appraise the quality of systematic reviews before applying to practice—we recommend the AMSTAR tool, which is very quick and easy to use.

We hope you find this resource useful and welcome feedback.

Eczema1

Atopic eczema (© CEBD)

 

Copyright © 2017 The University of Nottingham, on behalf of the Centre of Evidence Based Dermatology. ALL RIGHTS RESERVED.
Please reference this resource (as a web page citation) if you use it for research or publications.

 

Epidemiology and aetiology

Prevalence
 
Aetiology

2017 Interleukin 31 and skin diseases: A systematic review

2017 Is the atopic march related to confounding by genetics and early life environment? A systematic review of sibship and twin data

2017 The role of the skin microbiome in atopic dermatitis: a systematic review

2017 Interleukin-31 pathway and its role in atopic dermatitis: A systematic review

2017 Interleukin 4 -590C/T (rs2243250) polymorphism is associated with increased risk of atopic dermatitis: A meta-analysis of case-control studies

2017 Overview of systematic reviews in allergy epidemiology

2016 Skin absorption through atopic dermatitis skin: a systematic review

2016 A systematic review of the role of interleukin-17 and the interleukin-20 family in inflammatory allergic skin diseases

2016 Environmental factors associated with altered gut microbiota in children with eczema: A systematic review

2016 Prevalence and odds of Staphylococcus aureus carriage in atopic dermatitis: a systematic review and meta-analysis

2015 The role of yeast in atopic dermatitis revisited: A critical appraisal

2015 Twin studies of atopic dermatitis: interpretations and applications in the filaggrin era

2015 Biomarkers for atopic dermatitis: a systematic review and meta-analysis

2015 Interrelationships between atopic disorders in children: A meta-analysis based on ISAAC questionnaires

2015 RANTES gene polymorphisms are not associated with rheumatoid arthritis and atopic dermatitis: a meta-analysis

2015 Microorganism-induced exacerbations in atopic dermatitis: a possible preventive role for vitamin D?

2015 Factors that predict remission of infant atopic dermatitis: a systematic review

2014 Are the concepts of induction of remission and treatment of subclinical inflammation in atopic dermatitis clinically useful?

2014 The relationship between interleukin-18 polymorphisms and allergic disease: a meta-analysis

2014 CD14 polymorphisms, microbial exposure and allergic diseases: a systematic review of gene-environment interactions

2014 Autoimmunity in atopic dermatitis: biomarker or simply epiphenomenon?

2013 Association between the IL10 -1082A>G (rs1800896) single-nucleotide polymorphism and atopic dermatitis: a systematic review and meta-analysis

2012 Does "autoreactivity" play a role in atopic dermatitis?

2011 Atopic dermatitis and the hygiene hypothesis revisited

2009 Meta-analysis of genome-wide linkage studies of atopic dermatitis

2009 Filaggrin gene defects and risk of developing allergic sensitisation and allergic disorders: systematic review and meta-analysis

2009 Meta-analysis of filaggrin polymorphisms in eczema and asthma: robust risk factors in atopic disease

2007 Toward a major risk factor for atopic eczema: meta-analysis of filaggrin polymorphism data

2007 The role of the intestinal microbiota in the development of atopic disorders

2006 What causes worsening of eczema? A systematic review

2005 Atopic dermatitis and the 'hygiene hypothesis': too clean to be true?

2004 How atopic is atopic dermatitis?

 
Risk factors

2017 Early life antibiotic exposure increases the risk of developing allergic symptoms later in life: A meta-analysis

2017 Systematic review and meta-analysis of human skin diseases due to particulate matter

2017 Association between atopic manifestations and eosinophilic esophagitis: A systematic review and meta-analysis

2017 Allergic diseases in children with attention deficit hyperactivity disorder: a systematic review and meta-analysis

2017 Overview of systematic reviews in allergy epidemiology

2016 Meta-analysis of antenatal infection and risk of asthma and eczema

2016 Timing of allergenic food introduction to the infant diet and risk of allergic or autoimmune disease: A systematic review and meta-analysis

2016 Fish intake during pregnancy or infancy and allergic outcomes in children: a systematic review and meta-analysis

2016 Association of atopic dermatitis with smoking: A systematic review and meta-analysis

2016 Environmental factors associated with altered gut microbiota in children with eczema: A systematic review

2016 A systematic review of vigorous physical activity in eczema

2016 The march from early life food sensitization to allergic disease: a systematic review and meta-analyses of birth cohort studies

2016 Maternal vitamin D status and childhood asthma, wheeze, and eczema: A systematic review and meta-analysis

2016 Prenatal maternal stress and atopic diseases in the child: a systematic review of observational human studies

2016 Intestinal microbiota and allergic diseases: A systematic review

2016 The association between phthalate exposure and atopic dermatitis with a discussion of phthalate induced secretion of interleukin-1β and thymic stromal lymphopoietin

2015 Interrelationships between atopic disorders in children: A meta-analysis based on ISAAC questionnaires

2015 Twin studies of atopic dermatitis: interpretations and applications in the filaggrin era

2015 Is folate status a risk factor for asthma or other allergic diseases?

2015 Association of atopic dermatitis with being overweight and obese: a systematic review and metaanalysis

2015 Association between atopic dermatitis and autism spectrum disorders: a systematic review

2015 The influence of childhood traffic-related air pollution exposure on asthma, allergy and sensitization: a systematic review and a meta-analysis of birth cohort studies

2015 A systematic review of socioeconomic position in relation to asthma and allergic diseases

2015 Association of vitiligo and alopecia areata with atopic dermatitis: A systematic review and meta-analysis

2015 Exposure to 'farming' and objective markers of atopy: a systematic review and meta-analysis

2015 Factors that predict remission of infant atopic dermatitis: a systematic review

2015 Volatile organic compounds and risk of asthma and allergy: a systematic review

2014 Active or passive exposure to tobacco smoking and allergic rhinitis, allergic dermatitis, and food allergy in adults and children: a systematic review and meta-analysis

2014 CD14 polymorphisms, microbial exposure and allergic diseases: a systematic review of gene-environment interactions

2014 Birth weight and atopic dermatitis: systematic review and meta-analysis

2014 Guidelines of care for the management of atopic dermatitis: section 1. Diagnosis and assessment of atopic dermatitis (AAD guideline)

2013 Pet exposure and risk of atopic dermatitis at the pediatric age: a meta-analysis of birth cohort studies

2013 Does early life exposure to antibiotics increase the risk of eczema? A systematic review

2013 Obesity - a promoter of allergy?

2012 Impact of ambient temperature on children's health: a systematic review

2012 Perinatal cat and dog exposure and the risk of asthma and allergy in the urban environment: a systematic review of longitudinal studies

2012 Exposure to cats: update on risks for sensitization and allergic diseases

2012 Caesarean section delivery and atopic dermatitis - meta-analysis of observational studies PDF

2011 Association between biomarker-quantified antioxidant status during pregnancy and infancy and allergic disease during early childhood: a systematic review

2011 Association between domestic mould and mould components, and asthma and allergy in children: A systematic review

2011 Atopic dermatitis and the hygiene hypothesis revisited

2011 Respiratory and allergic health effects of dampness, mold, and dampness-related agents: a review of the epidemiologic evidence

2010 Is there a rural/urban gradient in the prevalence of eczema? A systematic review

2008 A bidirectional relationship between psychosocial factors and atopic disorders: a systematic review and meta-analysis

2008 Caesarean delivery and risk of atopy and allergic disease: meta-analyses

2007 Atopic eczema in under 12s: diagnosis and management (NICE guideline)

2007 The role of furry pets in eczema: a systematic review

2007 The role of the intestinal microbiota in the development of atopic disorders

2006 What causes worsening of eczema? A systematic review

2005 Atopic dermatitis and the 'hygiene hypothesis': too clean to be true?

2004 No epidemiological evidence for infant vaccinations to cause allergic disease

1998 Health effects of passive smoking. 5. Parental smoking and allergic sensitisation in children

 
Co-morbidities

2017 Risk factors in preschool children for predicting asthma during the preschool age and the early school age: A systematic review and meta-analysis

2017 The association between atopic dermatitis and hand eczema: a systematic review and meta-analysis

2017 Autoimmune diseases involving skin and intestinal mucosa are more frequent in adolescents and young adults suffering from atopic dermatitis

2017 Is the atopic march related to confounding by genetics and early life environment? A systematic review of sibship and twin data

2017 Contact allergy in children with atopic dermatitis: a systematic review

2017 Factors predicting persistence of early wheezing through childhood and adolescence: a systematic review of the literature

2017 Association between atopic manifestations and eosinophilic esophagitis: A systematic review and meta-analysis

2017 Association between atopic dermatitis and contact sensitization: A systematic review and meta-analysis

2017 Allergic diseases in children with attention deficit hyperactivity disorder: a systematic review and meta-analysis

2017 Allergy is associated with reduced risk of glioma: A meta-analysis

2017 Association of atopic diseases and attention-deficit/hyperactivity disorder: A systematic review and meta-analyses

2017 Overview of systematic reviews in allergy epidemiology

2017 Allergy reduces the risk of meningioma: a meta-analysis

2016 Eczema and educational attainment - a systematic review

2016 Career advice for young allergy patients

2016 Skin absorption through atopic dermatitis skin: a systematic review

2016 Evidence from a large-scale meta-analysis indicates eczema reduces the incidence of glioma

2016 Atopic dermatitis, naevi count and skin cancer risk: A meta-analysis

2016 A systematic review of vigorous physical activity in eczema

2016 The march from early life food sensitization to allergic disease: a systematic review and meta-analyses of birth cohort studies

2016 Does atopic dermatitis cause food allergy? A systematic review

2016 Prevalence and odds of Staphylococcus aureus carriage in atopic dermatitis: a systematic review and meta-analysis

2015 Interrelationships between atopic disorders in children: A meta-analysis based on ISAAC questionnaires

2015 Association between atopic dermatitis and autism spectrum disorders: a systematic review

2015 Risk of lymphoma in patients with atopic dermatitis and the role of topical treatment: A systematic review and meta-analysis

2015 [Nonallergic comorbidities of atopic dermatitis] (in German)

2015 Association of vitiligo and alopecia areata with atopic dermatitis: A systematic review and meta-analysis

2014 Guidelines of care for the management of atopic dermatitis: section 1. Diagnosis and assessment of atopic dermatitis (AAD guideline)

2014 Guidelines of care for the management of atopic dermatitis: Section 4. Prevention of disease flares and use of adjunctive therapies and approaches (AAD guideline)

2014 Nonallergic comorbidities of atopic eczema: an overview of systematic reviews

2011 Allergy and risk of glioma: a meta-analysis

2011 Inverse association between eczema and meningioma: a meta-analysis

2011 Association between allergies and multiple sclerosis: a systematic review and meta-analysis

2010 Is atopic disease a risk factor for attention-deficit/hyperactivity disorder? A systematic review

2010 The association between atopy and childhood/adolescent leukemia: a meta-analysis

2008 Alexithymia and dermatology: the state of the art

2007 Atopic eczema in under 12s: diagnosis and management (NICE guideline)

2007 Atopy and risk of brain tumors: a meta-analysis

2007 Risk of developing asthma in young children with atopic eczema: a systematic review

2006 Atopic dermatitis and cancer risk

2005 Is atopy a protective or a risk factor for cancer? A review of epidemiological studies

2003 A meta-analysis of the association between childhood type 1 diabetes and atopic disease

 
Diagnosis & evaluation

2017 Severity assessments used for inclusion criteria and baseline severity evaluation in atopic dermatitis clinical trials: a systematic review

2017 Systematic review of diagnostic criteria used in atopic dermatitis randomized controlled trials

2016 Recent trends in disease severity and quality of life instruments for patients with atopic dermatitis: A systematic review

2016 Strategies used for measuring long-term control in atopic dermatitis trials: A systematic review

2016 Measurement properties of quality-of-life measurement instruments for infants, children and adolescents with eczema: a systematic review

2016 Atopic dermatitis, atopic eczema or eczema? A systematic review, meta-analysis and recommendation for uniform use of "atopic dermatitis"

2016 Evaluation of the measurement properties of symptom measurement instruments for atopic eczema: a systematic review

2016 A systematic review of Investigator Global Assessment (IGA) in atopic dermatitis (AD) trials: Many options, no standards

2016 Eczema trials: quality of life instruments used and their relation to patient-reported outcomes. A systematic review

2016 Measurement properties of adult quality-of-life measurement instruments for eczema: a systematic review

2016 Reporting of symptoms in randomised controlled trials of atopic eczema treatments: a systematic review

2015 Systematic review on the definition of allergic diseases in children: The MeDALL Study

2015 Biomarkers for atopic dermatitis: a systematic review and meta-analysis

2014 Guidelines of care for the management of atopic dermatitis: section 1. Diagnosis and assessment of atopic dermatitis (AAD guideline)

2014 Are the concepts of induction of remission and treatment of subclinical inflammation in atopic dermatitis clinically useful?

2014 How are eczema 'flares' defined? A systematic review and recommendation for future studies

2013 Assessment of clinical signs of atopic dermatitis: a systematic review and recommendation

2012 Prospective registration and outcome-reporting bias in randomized controlled trials of eczema treatments: a systematic review

2012 How should an incident case of atopic dermatitis be defined? A systematic review of primary prevention studies

2011 Health outcome measures in atopic dermatitis: a systematic review of trends in disease severity and quality-of-life instruments 1985-2010

2011 Management of atopic eczema in primary care (SIGN guideline) PDF

2008 Diagnostic criteria for atopic dermatitis: a systematic review

2007 Atopic eczema in under 12s: diagnosis and management (NICE guideline)

2007 What are the best outcome measurements for atopic eczema? A systematic review

2006 What is meant by a "flare" in atopic dermatitis? A systematic review and proposal

2004 How atopic is atopic dermatitis?

2003 Measuring atopic dermatitis severity in randomized controlled clinical trials: what exactly are we measuring?

2000 Outcome measures of disease severity in atopic eczema

 
Disease impact & treatment cost-effectiveness

2017 The use of decision-analytic models in atopic eczema: A systematic review and critical appraisal

2017 The impact of atopic dermatitis on work life - a systematic review

2017 Frequency and management of sleep disturbance in adults with atopic dermatitis: A systematic review

2017 Topical corticosteroid phobia in atopic dermatitis: A systematic review

2017 Global skin disease morbidity and mortality: An update from the Global Burden of Disease Study 2013

2017 Itch intensity in moderate-to-severe plaque psoriasis versus atopic dermatitis: A meta-analysis

2017 Measuring the impact of dermatological conditions on family and caregivers: a review of dermatology-specific instruments

2016 Parental, child, and adolescent experience of chronic skin conditions: A meta-ethnography and review of the qualitative literature

2016 Eczema and educational attainment - a systematic review

2016 Career advice for young allergy patients

2016 Skin absorption through atopic dermatitis skin: a systematic review

2016 Recent trends in disease severity and quality of life instruments for patients with atopic dermatitis: A systematic review

2016 Persistence of atopic dermatitis (AD): A systematic review and meta-analysis

2016 Measurement properties of adult quality-of-life measurement instruments for eczema: a systematic review

2016 Quality of life impact of childhood skin conditions measured using the Children's Dermatology Life Quality Index (CDLQI): a meta-analysis

2016 Eczema trials: quality of life instruments used and their relation to patient-reported outcomes. A systematic review

2014 Guidelines of care for the management of atopic dermatitis: section 1. Diagnosis and assessment of atopic dermatitis (AAD guideline)

2008 A bidirectional relationship between psychosocial factors and atopic disorders: a systematic review and meta-analysis

2008 Sleep disruptions in parents of children and adolescents with chronic illnesses: prevalence, causes, and consequences

2008 The socioeconomic impact of atopic dermatitis in the United States: a systematic review

2007 Atopic eczema in under 12s: diagnosis and management (NICE guideline)

2003 Treatment of atopic dermatitis and impact on quality of life: a review with emphasis on topical non-corticosteroids

 
Trial methodology
 


Prevention

Maternal diet

2017 Vitamin D supplementation in primary allergy prevention: systematic review of randomized and non-randomized studies

2017 Prenatal intake of vitamins and allergic outcomes in the offspring: A systematic review and meta-analysis

2017 Overview of systematic reviews in allergy epidemiology

2016 Omega-3 Fatty Acids and Maternal and Child Health: An Updated Systematic Review

2016 Fish intake during pregnancy or infancy and allergic outcomes in children: a systematic review and meta-analysis

2016 Maternal vitamin D status and childhood asthma, wheeze and eczema: a systematic review and meta-analysis

2016 Omega-3 long-chain PUFA intake during pregnancy and allergic disease outcomes in the offspring: a systematic review and meta-analysis of observational studies and randomized controlled trials

2016 World Allergy Organization-McMaster University Guidelines for Allergic Disease Prevention (GLAD-P): Prebiotics

2015 Maternal prenatal and/or postnatal n-3 long chain polyunsaturated fatty acids (LCPUFA) supplementation for preventing allergies in early childhood (Cochrane Review)

2015 Maternal nutrition during pregnancy and risk of asthma, wheeze, and atopic diseases during childhood: a systematic review and meta-analysis

2015 Probiotics for the prevention of allergy: a systematic review and meta-analysis of randomized controlled trials

2015 World Allergy Organization-McMaster University Guidelines for Allergic Disease Prevention (GLAD-P): Probiotics

2014 Does maternal diet during pregnancy and lactation affect outcomes in offspring? A systematic review of food-based approaches

2014 Maternal folate exposure in pregnancy and childhood asthma and allergy: a systematic review

2013 Diet and allergic diseases among population aged 0 to 18 years: myth or reality?

2012 Maternal dietary antigen avoidance during pregnancy or lactation, or both, for preventing or treating atopic disease in the child (Cochrane Review)

2012 Impact of maternal supplementation with probiotics during pregnancy on atopic eczema in childhood - a meta-analysis

2012 Probiotics supplementation during pregnancy or infancy for the prevention of atopic dermatitis: a meta-analysis

2012 The impact of vitamin D in pregnancy on extraskeletal health in children: A systematic review

2011 The effect of perinatal omega-3 fatty acid supplementation on inflammatory markers and allergic diseases: a systematic review

2011 Overview of Reviews. The prevention of eczema in infants and children: an overview of Cochrane and non-Cochrane reviews

2011 BMJ Clinical Evidence - Eczema

2011 Management of atopic eczema in primary care (SIGN guideline) PDF

2010 Diagnosing and managing common food allergies: a systematic review

2010 Prevalence, natural history, diagnosis, and treatment of food allergy: a systematic review of the evidence

2008 Systematic review and evidence-based consensus guideline on prevention of allergy and atopic eczema of the German Network on Allergy Prevention (ABAP)

2002 Complementary/alternative medicine in dermatology: evidence-assessed efficacy of two diseases and two treatments

2000 Systematic review of treatments for atopic eczema

 
Breastfeeding

2017 Association of breast milk fatty acids and allergic disease outcomes - a systematic review

2017 Overview of systematic reviews in allergy epidemiology

2015 Breastfeeding and asthma and allergies: a systematic review and meta-analysis

2012 Optimal duration of exclusive breastfeeding (Cochrane Review)

2011 Overview of Reviews. The prevention of eczema in infants and children: an overview of Cochrane and non-Cochrane reviews

2011 BMJ Clinical Evidence - Eczema

2011 Management of atopic eczema in primary care (SIGN guideline) PDF

2010 Diagnosing and managing common food allergies: a systematic review

2010 Prevalence, natural history, diagnosis, and treatment of food allergy: a systematic review of the evidence

2010 A systematic review of the importance of milk TGF-beta on immunological outcomes in the infant and young child

2009 Exclusive breastfeeding and incident atopic dermatitis in childhood: a systematic review and meta-analysis of prospective cohort studies

2009 The long-term effects of breastfeeding on asthma and atopic disease

2008 Systematic review and evidence-based consensus guideline on prevention of allergy and atopic eczema of the German Network on Allergy Prevention (ABAP)

2007 Breastfeeding and maternal and infant health outcomes in developed countries

2004 The optimal duration of exclusive breastfeeding: a systematic review

2001 Breast-feeding and the onset of atopic dermatitis in childhood: a systematic review and meta-analysis of prospective studies

2000 Systematic review of treatments for atopic eczema

 
Dietary & supplements (for prevention)

2017 Prebiotics for the prevention of allergies: a systematic review and meta-analysis of randomized controlled trials

2017 Vitamin D supplementation in primary allergy prevention: systematic review of randomized and non-randomized studies

2017 Infant formulas containing hydrolysed protein for prevention of allergic disease and food allergy (Cochrane Review - TEMPORARILY WITHDRAWN DUE TO DATA ERROR)

2017 Overview of systematic reviews in allergy epidemiology

2016 Omega-3 fatty acids and maternal and child health: An updated systematic review

2016 Polyunsaturated fatty acid supplementation in infancy for the prevention of allergy

2016 Fish intake during pregnancy or infancy and allergic outcomes in children: a systematic review and meta-analysis

2016 Timing of allergenic food introduction to the infant diet and risk of allergic or autoimmune disease: A systematic review and meta-analysis

2016 Synbiotics for prevention and treatment of atopic dermatitis: a meta-analysis of randomized clinical trials

2016 Hydrolysed formula and risk of allergic or autoimmune disease: systematic review and meta-analysis

2016 World Allergy Organization-McMaster University Guidelines for Allergic Disease Prevention (GLAD-P): Prebiotics

2015 Probiotics and primary prevention of atopic dermatitis: a meta-analysis of randomized controlled studies

2015 Long-term effect of early-life supplementation with probiotics on preventing atopic dermatitis: A meta-analysis

2015 Probiotics for prevention of atopic diseases in infants: systematic review and meta-analysis

2015 Probiotics for the prevention of allergy: a systematic review and meta-analysis of randomized controlled trials

2015 World Allergy Organization-McMaster University Guidelines for Allergic Disease Prevention (GLAD-P): Probiotics

2014 Comparative probiotic strain efficacy in the prevention of eczema in infants and children: a systematic review and meta-analysis

2014 The importance of allergen avoidance in high risk infants and sensitized patients: a meta-analysis study

2013 Prebiotics in infants for prevention of allergy (Cochrane Review)

2013 Meta-analysis of probiotics and/or prebiotics for the prevention of eczema

2013 Effect of nutrient supplementation on atopic dermatitis in children: a systematic review of probiotics, prebiotics, formula, and fatty acids

2013 Diet and allergic diseases among population aged 0 to 18 years: myth or reality?

2013 The use of prebiotics during the first year of life for atopy prevention and treatment

2012 [Preventative effects of probiotics for infantile eczema and atopic eczema: A systematic review] (in Chinese) PDF

2012 Probiotics supplementation during pregnancy or infancy for the prevention of atopic dermatitis: a meta-analysis

2012 [Meta-analysis of probiotics preventing allergic diseases in infants] (in Chinese)

2012 Are organic foods safer or healthier than conventional alternatives? A systematic review

2011 Overview of Reviews. The prevention of eczema in infants and children: an overview of Cochrane and non-Cochrane reviews

2011 Supplementation of infant formula with probiotics and/or prebiotics: A systematic review and comment by the ESPGHAN committee on nutrition

2011 Atopy risk in infants and children in relation to early exposure to fish, oily fish, or long-chain omega-3 fatty acids: a systematic review

2011 BMJ Clinical Evidence - Eczema

2011 Management of atopic eczema in primary care (SIGN guideline) PDF

2011 Nutrients and foods for the primary prevention of asthma and allergy: systematic review and meta-analysis

2010 Nutrition-related health effects of organic foods: a systematic review

2010 [Meta analysis of lactic acid bacteria as probiotics for the primary prevention of infantile eczema] (in Chinese)

2010 Meta-analysis of the evidence for a partially hydrolyzed 100% whey formula for the prevention of allergic diseases

2010 Diagnosing and managing common food allergies: a systematic review

2010 Prevalence, natural history, diagnosis, and treatment of food allergy: a systematic review of the evidence

2010 Partially hydrolyzed 100% whey protein infant formula and reduced risk of atopic dermatitis: a meta-analysis

2010 Partially hydrolyzed 100% whey protein infant formula and atopic dermatitis risk reduction: a systematic review of the literature

2009 Omega 3 and 6 oils for primary prevention of allergic disease: systematic review and meta-analysis

2008 Meta-analysis of clinical trials of probiotics for prevention and treatment of pediatric atopic dermatitis

2008 Systematic review and evidence-based consensus guideline on prevention of allergy and atopic eczema of the German Network on Allergy Prevention (ABAP)

2008 Probiotics for the treatment or prevention of atopic dermatitis: a review of the evidence from randomized controlled trials

2007 Probiotics in infants for prevention of allergic disease and food hypersensitivity (Cochrane Review)

2007 The efficacy of amino acid-based formulas in relieving the symptoms of cow's milk allergy: a systematic review

2006 Formulas containing hydrolysed protein for prevention of allergy and food intolerance in infants (Cochrane Review)

2006 Soy formula for prevention of allergy and food intolerance in infants (Cochrane Review)

2006 Systematic review of the relationship between early introduction of solid foods to infants and the development of allergic disease

2005 Atopic dermatitis and the 'hygiene hypothesis': too clean to be true?

2005 A systematic review of the role of hydrolyzed infant formulas in allergy prevention

2001 Prospective cohort studies using hydrolysed formulas for allergy prevention in atopy-prone newborns: a systematic review

2000 Systematic review of treatments for atopic eczema

 
Aeroallergen reduction (for prevention)
 
Other prevention
 


Topical treatments

Topical corticosteroids

2017 Topical corticosteroid phobia in atopic dermatitis: A systematic review

2016 Efficacy and safety of wet wrap therapy for patients with atopic dermatitis: a systematic review and meta-analysis

2016 What is the evidence-base for atopic eczema treatments? A summary of published randomised controlled trials

2016 Systematic review of published trials: long-term safety of topical corticosteroids and topical calcineurin inhibitors in pediatric patients with atopic dermatitis

2016 Scoping systematic review of treatments for eczema

2016 Systematic review and meta-analysis of randomized clinical trials (RCTs) comparing topical calcineurin inhibitors with topical corticosteroids for atopic dermatitis: A 15-year experience

2015 Topical corticosteroid-induced skin atrophy: a comprehensive review

2015 Safety of topical corticosteroids in pregnancy (Cochrane Review)

2015 A systematic review of topical corticosteroid withdrawal ("steroid addiction") in patients with atopic dermatitis and other dermatoses

2015 Risk of lymphoma in patients with atopic dermatitis and the role of topical treatment: A systematic review and meta-analysis

2014 Guidelines of care for the management of atopic dermatitis: section 2. Management and treatment of atopic dermatitis with topical therapies (AAD guideline)

2014 Guidelines of care for the management of atopic dermatitis: Section 4. Prevention of disease flares and use of adjunctive therapies and approaches (AAD guideline)

2012 Relieving the pruritus of atopic dermatitis: a meta-analysis

2011 A systematic review of tacrolimus ointment compared with corticosteroids in the treatment of atopic dermatitis

2011 Efficacy and tolerability of proactive treatment with topical corticosteroids and calcineurin inhibitors for atopic eczema: systematic review and meta-analysis of randomized controlled trials

2011 BMJ Clinical Evidence - Eczema

2011 Management of atopic eczema in primary care (SIGN guideline) PDF

2007 Atopic eczema in under 12s: diagnosis and management (NICE guideline)

2007 A systematic review of the safety of topical therapies for atopic dermatitis

2005 Topical corticosteroids for atopic eczema: clinical and cost effectiveness of once-daily vs. more frequent use

2004 Clinical and cost-effectiveness of once-daily versus more frequent use of same potency topical corticosteroids for atopic eczema: a systematic review and economic evaluation

2003 Treatment of atopic dermatitis and impact on quality of life: a review with emphasis on topical non-corticosteroids

2000 Systematic review of treatments for atopic eczema

 
Topical calcineurin inhibitors

2016 What is the evidence-base for atopic eczema treatments? A summary of published randomised controlled trials

2016 Systematic review of published trials: long-term safety of topical corticosteroids and topical calcineurin inhibitors in pediatric patients with atopic dermatitis

2016 How clinically relevant are treatment comparisons of topical calcineurin inhibitor trials for atopic eczema?

2016 Scoping systematic review of treatments for eczema

2016 Systematic review and meta-analysis of randomized clinical trials (RCTs) comparing topical calcineurin inhibitors with topical corticosteroids for atopic dermatitis: A 15-year experience

2015 Topical tacrolimus for atopic dermatitis (Cochrane Review)

2015 Efficacy and safety of tacrolimus versus pimecrolimus for the treatment of atopic dermatitis in children: a network meta-analysis

2015 Systematic review on the efficacy, safety, and cost-effectiveness of topical calcineurin inhibitors in atopic dermatitis

2015 Risk of lymphoma in patients with atopic dermatitis and the role of topical treatment: A systematic review and meta-analysis

2014 Guidelines of care for the management of atopic dermatitis: section 2. Management and treatment of atopic dermatitis with topical therapies (AAD guideline)

2014 Guidelines of care for the management of atopic dermatitis: Section 4. Prevention of disease flares and use of adjunctive therapies and approaches (AAD guideline)

2014 [RETRACTED ARTICLE - Pimecrolimus cream 1% in the management of atopic dermatitis in pediatric patients: a meta-analysis]

2012 Relieving the pruritus of atopic dermatitis: a meta-analysis

2011 Efficacy and tolerance of tacrolimus and pimecrolimus for atopic dermatitis: A meta-analysis

2011 A systematic review of tacrolimus ointment compared with corticosteroids in the treatment of atopic dermatitis

2011 Efficacy and tolerability of proactive treatment with topical corticosteroids and calcineurin inhibitors for atopic eczema: systematic review and meta-analysis of randomized controlled trials

2011 BMJ Clinical Evidence - Eczema

2011 Management of atopic eczema in primary care (SIGN guideline) PDF

2010 Two topical calcineurin inhibitors for the treatment of atopic dermatitis in pediatric patients: a meta-analysis of randomized clinical trials

2010 An approach to pruritus in atopic dermatitis: a critical systematic review of the tacrolimus ointment literature

2009 Topical calcineurin inhibitors in atopic dermatitis: a systematic review and meta-analysis

2008 Meta-analysis of tacrolimus ointment for atopic dermatitis in pediatric patients

2007 Atopic eczema in under 12s: diagnosis and management (NICE guideline)

2007 Topical pimecrolimus for eczema (Cochrane Review)

2007 Efficacy and tolerability of topical tacrolimus in the treatment of atopic dermatitis: a systematic review of randomized controlled trials

2007 A systematic review of the safety of topical therapies for atopic dermatitis

2006 Review of pimecrolimus cream 1% for the treatment of mild to moderate atopic dermatitis

2005 Efficacy and tolerability of topical pimecrolimus and tacrolimus in the treatment of atopic dermatitis: meta-analysis of randomised controlled trials

2005 The effectiveness and cost-effectiveness of pimecrolimus and tacrolimus for atopic eczema: a systematic review and economic evaluation

2004 Topical calcineurin inhibitors in the treatment of atopic dermatitis: a meta-analysis of current evidence

2003 Treatment of atopic dermatitis and impact on quality of life: a review with emphasis on topical non-corticosteroids

2000 Systematic review of treatments for atopic eczema

 
Emollients
 
Topical antimicrobials
 
Occlusive therapies
 
Other topical treatments
 


Systemic treatments

Systemic corticosteroids
 
Systemic immune modulators
 
Immunotherapy/desensitisation

2016 What is the evidence-base for atopic eczema treatments? A summary of published randomised controlled trials

2016 Scoping systematic review of treatments for eczema

2016 Specific allergen immunotherapy for the treatment of atopic eczema: a Cochrane systematic review

2016 Specific allergen immunotherapy for the treatment of atopic eczema (Cochrane Review)

2015 Sublingual immunotherapy in the treatment of atopic dermatitis: a systematic review using the GRADE system

2014 Efficacy and safety of systemic treatments for moderate-to-severe atopic dermatitis: a systematic review

2014 Guidelines of care for the management of atopic dermatitis: Section 4. Prevention of disease flares and use of adjunctive therapies and approaches (AAD guideline)

2013 Efficacy of allergen-specific immunotherapy for atopic dermatitis: a systematic review and meta-analysis of randomized controlled trials

2013 Specific immunotherapy in the treatment of atopic dermatitis: a systematic review using the GRADE system

2012 Evidences of efficacy of allergen immunotherapy in atopic dermatitis: an updated review

2012 Relieving the pruritus of atopic dermatitis: a meta-analysis

2012 Omalizumab beyond asthma

2011 SIT beyond respiratory diseases

2010 Off-label use of efalizumab in dermatology

2007 Atopic eczema in under 12s: diagnosis and management (NICE guideline)

2007 Systemic treatment of severe atopic eczema: a systematic review

2006 Does allergen-specific immunotherapy represent a therapeutic option for patients with atopic dermatitis?

2000 Systematic review of treatments for atopic eczema

 
Systemic antimicrobials
 
Anti-histamine/anti-allergic
 
Dietary & supplements (for treatment)

2017 The role of elimination diets in atopic dermatitis - A comprehensive review

2017 Probiotics for the treatment of atopic dermatitis in children: A systematic review and meta-analysis of randomized controlled trials

2017 Probiotics, prebiotics, and synbiotics for the treatment and prevention of adult dermatological diseases

2016 Vitamin D status and efficacy of vitamin D supplementation in atopic dermatitis: A systematic review and meta-analysis

2016 What is the evidence-base for atopic eczema treatments? A summary of published randomised controlled trials

2016 Complementary and alternative medicine for atopic dermatitis: An evidence-based review

2016 Scoping systematic review of treatments for eczema

2016 Synbiotics for prevention and treatment of atopic dermatitis: a meta-analysis of randomized clinical trials

2016 Vitamin D and atopic dermatitis: A systematic review and meta-analysis

2015 Microorganism-induced exacerbations in atopic dermatitis: a possible preventive role for vitamin D?

2014 Effectiveness of vitamin D supplementation in the management of atopic dermatitis: A review of current evidence

2014 Effects of probiotics for the treatment of atopic dermatitis: a meta-analysis of randomized controlled trials

2014 Guidelines of care for the management of atopic dermatitis: Section 4. Prevention of disease flares and use of adjunctive therapies and approaches (AAD guideline)

2013 Effect of nutrient supplementation on atopic dermatitis in children: a systematic review of probiotics, prebiotics, formula, and fatty acids

2013 Effect of the use of probiotics in the treatment of children with atopic dermatitis; a literature review

2013 Oral evening primrose oil and borage oil for eczema (Cochrane Review)

2012 Relieving the pruritus of atopic dermatitis: a meta-analysis

2012 Dietary supplements for established atopic eczema (Cochrane Review)

2011 BMJ Clinical Evidence - Eczema

2011 Management of atopic eczema in primary care (SIGN guideline) PDF

2010 Diagnosing and managing common food allergies: a systematic review

2010 Prevalence, natural history, diagnosis, and treatment of food allergy: a systematic review of the evidence

2009 Probiotics for the treatment of eczema: a systematic review

2009 Dietary exclusions for improving established atopic eczema in adults and children: systematic review

2008 Probiotics for treating eczema (Cochrane Review)

2008 Efficacy of probiotics in the treatment of pediatric atopic dermatitis: a meta-analysis of randomized controlled trials

2008 Meta-analysis of clinical trials of probiotics for prevention and treatment of pediatric atopic dermatitis

2008 Probiotics for the treatment or prevention of atopic dermatitis: a review of the evidence from randomized controlled trials

2008 Dietary exclusions for established atopic eczema (Cochrane Review)

2007 Atopic eczema in under 12s: diagnosis and management (NICE guideline)

2006 What causes worsening of eczema? A systematic review

2005 Atopic dermatitis and the 'hygiene hypothesis': too clean to be true?

2004 Dietary treatment of childhood atopic eczema/dermatitis syndrome (AEDS)

2004 Oral essential fatty acid supplementation in atopic dermatitis-a meta-analysis of placebo-controlled trials

2002 Complementary/alternative medicine in dermatology: evidence-assessed efficacy of two diseases and two treatments

2000 Systematic review of treatments for atopic eczema

 
Other systemic treatments

2017 Are biologics efficacious in atopic dermatitis? A systematic review and meta-analysis

2017 A systematic review of ustekinumab in the treatment of atopic dermatitis

2017 Adverse events of dupilumab in adults with moderate-to-severe atopic dermatitis: A meta-analysis

2017 Risk of infection in patients with atopic dermatitis treated with dupilumab: A meta-analysis of randomized controlled trials

2017 Efficacy and safety of dupilumab for the treatment of adult atopic dermatitis: A meta-analysis of randomized clinical trials

2017 Tofacitinib, an oral Janus kinase inhibitor: Perspectives in dermatology

2016 Dermatologic uses of omalizumab

2016 What is the evidence-base for atopic eczema treatments? A summary of published randomised controlled trials

2016 Efficacy of omalizumab in patients with atopic dermatitis: A systematic review and meta-analysis

2016 Omalizumab for atopic dermatitis: case series and a systematic review of the literature

2016 Scoping systematic review of treatments for eczema

2016 An evidence-based review of systemic treatments for itch

2014 Efficacy and safety of systemic treatments for moderate-to-severe atopic dermatitis: a systematic review

2014 Guidelines of care for the management of atopic dermatitis: section 3. Management and treatment with phototherapy and systemic agents (AAD guideline)

2007 Atopic eczema in under 12s: diagnosis and management (NICE guideline)

2005 Atopic dermatitis and the 'hygiene hypothesis': too clean to be true?

2000 Systematic review of treatments for atopic eczema

 


Other treatments

Phototherapy
 
Psychological & educational

2017 Frequency and management of sleep disturbance in adults with atopic dermatitis: A systematic review

2017 Systematic review of self-management interventions for people with eczema

2016 What is the evidence-base for atopic eczema treatments? A summary of published randomised controlled trials

2016 Scoping systematic review of treatments for eczema

2016 The effectiveness of written action plans in atopic dermatitis

2016 Education to improve quality of life of people with chronic inflammatory skin conditions: a systematic review of the evidence

2015 Educational interventions to improve quality of life in people with chronic inflammatory skin diseases: systematic reviews of clinical effectiveness and cost-effectiveness

2015 Educational programs for the management of childhood atopic dermatitis: an integrative review

2015 Interventions to increase treatment adherence in pediatric atopic dermatitis: A systematic review

2015 Psychological interventions for parents of children and adolescents with chronic illness (Cochrane Review)

2015 A review of multidisciplinary interventions in atopic dermatitis

2014 Psychological and educational interventions for atopic eczema in children (Cochrane Review)

2014 Guidelines of care for the management of atopic dermatitis: Section 4. Prevention of disease flares and use of adjunctive therapies and approaches (AAD guideline)

2012 A meta-analysis of the effectiveness of psychological interventions for adults with skin conditions

2011 Management of atopic eczema in primary care (SIGN guideline) PDF

2011 Patient education in chronic skin diseases: a systematic review

2010 Patient and parental education programs for atopic neurodermatitis. Evidence-based literature review on their effectiveness in the rehabilitation of children and adolescents with atopic dermatitis

2008 Written action plans: potential for improving outcomes in children with atopic dermatitis

2007 Atopic eczema in under 12s: diagnosis and management (NICE guideline)

2007 The effects of psychological intervention on atopic dermatitis. A systematic review and meta-analysis

2006 Nurse-led clinics reduce severity of childhood atopic eczema: a review of the literature

2000 Systematic review of treatments for atopic eczema

 
Aeroallergen reduction (for treatment)
 
Laundering techniques 
 
Clothing
 
Bathing & water softeners
 
Chinese herbal medicine

2017 The traditional Chinese medicine and relevant treatment for the efficacy and safety of atopic dermatitis: A systematic review and meta-analysis of randomized controlled trials

2016 What is the evidence-base for atopic eczema treatments? A summary of published randomised controlled trials

2016 Chinese herbal medicine for atopic eczema: an overview of clinical evidence

2016 Complementary and alternative medicine for atopic dermatitis: An evidence-based review

2016 Scoping systematic review of treatments for eczema

2014 Efficacy and safety of systemic treatments for moderate-to-severe atopic dermatitis: a systematic review

2014 Guidelines of care for the management of atopic dermatitis: Section 4. Prevention of disease flares and use of adjunctive therapies and approaches (AAD guideline)

2014 Topical application of Chinese herbal medicine for atopic eczema: a systematic review with a meta-analysis

2013 Chinese herbal medicine for atopic dermatitis: a systematic review

2013 Chinese herbal medicine for atopic eczema (Cochrane Review)

2012 Relieving the pruritus of atopic dermatitis: a meta-analysis

2011 Chinese herbal medicine research in eczema treatment

2011 Management of atopic eczema in primary care (SIGN guideline) PDF

2010 Botanicals in dermatology: an evidence-based review

2007 Atopic eczema in under 12s: diagnosis and management (NICE guideline)

2007 Systemic treatment of severe atopic eczema: a systematic review

2002 Complementary/alternative medicine in dermatology: evidence-assessed efficacy of two diseases and two treatments

2000 Systematic review of treatments for atopic eczema

 
Complementary & alternative therapies

2017 The traditional Chinese medicine and relevant treatment for the efficacy and safety of atopic dermatitis: A systematic review and meta-analysis of randomized controlled trials

2016 What is the evidence-base for atopic eczema treatments? A summary of published randomised controlled trials

2016 Topical herbal medicines for atopic eczema: A systematic review of randomised controlled trials

2016 Complementary and alternative medicine for atopic dermatitis: An evidence-based review

2016 Scoping systematic review of treatments for eczema

2015 Efficacy of acupuncture in the management of atopic dermatitis: a systematic review

2015 Acupuncture as a treatment modality in dermatology: A systematic review

2015 Alpine climate treatment of atopic dermatitis: a systematic review

2014 Guidelines of care for the management of atopic dermatitis: Section 4. Prevention of disease flares and use of adjunctive therapies and approaches (AAD guideline)

2012 Homeopathy for eczema: a systematic review of controlled clinical trials

2012 Relieving the pruritus of atopic dermatitis: a meta-analysis

2011 Homoeopathic remedies in dermatology: A systematic review of controlled clinical trials

2011 Management of atopic eczema in primary care (SIGN guideline) PDF

2010 Botanicals in dermatology: an evidence-based review

2007 Atopic eczema in under 12s: diagnosis and management (NICE guideline)

2002 Complementary/alternative medicine in dermatology: evidence-assessed efficacy of two diseases and two treatments

2000 Systematic review of treatments for atopic eczema

 

Centre of Evidence Based Dermatology

The University of Nottingham
King's Meadow Campus
Lenton Lane
Nottingham, NG7 2NR


telephone: +44 (0) 115 823 1048
email:cebd@nottingham.ac.uk