Centre of Evidence Based Dermatology

Systematic reviews on hidradenitis suppurativa

March 2021: This resource is now archived and no longer being updated.

We recommend the Epistemonikos database as a comprehensive, searchable database of systematic reviews. 

This page is a mapping by topic of systematic reviews on hidradenitis suppurativa, based on searches of PubMed and other sources. Links are given to the PubMed abstract, or the original publication if not in PubMed.

HS cropped

Hidradenitis suppurativa (© Dr John Ingram)

 

Copyright © 2021 The University of Nottingham, on behalf of the Centre of Evidence Based Dermatology. ALL RIGHTS RESERVED.
Please reference this resource (as a web page citation) if you use it for research or publications.

 

Guidelines 

Guidelines

NICE Technology Appraisal (TA392) - Adalimumab for treating moderate to severe hidradenitis suppurativa

British Association of Dermatologists guidelines for the management of hidradenitis suppurativa (acne inversa) 2018.
Ingram JR, Collier F, Brown D, Burton T, Burton J, Chin MF, Desai N, Goodacre TEE, Piguet V, Pink AE, Exton LS, Mohd Mustapa MF.
Br J Dermatol. 2018 Dec 15. doi: 10.1111/bjd.17537. [Epub ahead of print]

North American Clinical Management Guidelines for Hidradenitis Suppurativa: a Publication from the United States and Canadian Hidradenitis Suppurativa Foundations. Part I: Diagnosis, Evaluation, and the use of Complementary and Procedural Management.
Alikhan A, Sayed C, Alavi A, Alhusayen R, Brasasard A, Burkhart C, Crowell K, Eisen D, Gottlieb A, Hamzavi I, Hazen P, Jaleel T, Kimball A, Kirby J, Lowes MA, Micheletti R, Miller A, Naik HB, Orgill D, Poulin Y.
J Am Acad Dermatol. 2019 Mar 11. pii: S0190-9622(19)30367-6. doi: 10.1016/j.jaad.2019.02.067. [Epub ahead of print]

North American Clinical Management Guidelines for Hidradenitis Suppurativa: a Publication from the United States and Canadian Hidradenitis Suppurativa Foundations. Part II: Topical, Intralesional, and Systemic medical Management.
Alikhan A, Sayed C, Alavi A, Alhusayen R, Brasasard A, Burkhart C, Crowell K, Eisen D, Gottlieb A, Hamzavi I, Hazen P, Jaleel T, Kimball A, Kirby J, Lowes MA, Micheletti R, Miller A, Naik HB, Orgill D, Poulin Y.
J Am Acad Dermatol. 2019 Mar 11. pii: S0190-9622(19)30368-8. doi: 10.1016/j.jaad.2019.02.068. [Epub ahead of print]

Comorbidity screening in hidradenitis suppurativa: Evidence-based recommendations from the US and Canadian Hidradenitis Suppurativa Foundations.
Garg A, Malviya N, Strunk A, Wright S, Alavi A, Alhusayen R, Alikhan A, Daveluy SD, Delorme I, Goldfarb N, Gulliver W, Hamzavi I, Jaleel T, Kimball AB, Kirby JS, Kirchhof Md MG, Lester J, Lev-Tov H, Lowes MA, Micheletti R, Orenstein LA, Piguet V, Sayed C, Tan J, Naik HB.
J Am Acad Dermatol. 2021 Jan 22:S0190-9622(21)00213-9. doi: 10.1016/j.jaad.2021.01.059. Online ahead of print.

Swiss Practice Recommendations for the Management of Hidradenitis Suppurativa/Acne Inversa.
Hunger RE, Laffitte E, Läuchli S, Mainetti C, Mühlstädt M, Schiller P, Lapointe AK, Meschberger P, Navarini AA.
Dermatology. 2017;233(2-3):113-119. doi: 10.1159/000477459. Epub 2017 Jul 7.

Hidradenitis suppurativa: guidelines of the Italian Society of Dermatology and Venereology (SIDeMaST) for the use of anti-TNF-α agents.
Megna M, Bettoli V, Chimenti S, Chiricozzi A, Naldi L, Virgili A, Girolomoni G, Monfrecola G.
G Ital Dermatol Venereol. 2015 Dec;150(6):731-9.

European S1 guideline for the treatment of hidradenitis suppurativa/acne inversa.
Zouboulis CC, Desai N, Emtestam L, Hunger RE, Ioannides D, Juhász I, Lapins J, Matusiak L, Prens EP, Revuz J, Schneider-Burrus S, Szepietowski JC, van der Zee HH, Jemec GB.
J Eur Acad Dermatol Venereol. 2015 Apr;29(4):619-44. doi: 10.1111/jdv.12966. Epub 2015 Jan 30.

 

 

Epidemiology & aetiology

Aetiology, risk factors & diagnosis

Hidradenitis suppurativa and chromosomal abnormalities: a case report and systematic review of the literature.
Shah M, Sachdeva M, Melendez-Gonzalez M, Piguet V, Sayed C.
Int J Dermatol. 2021 Mar;60(3):261-271. doi: 10.1111/ijd.15111. Epub 2020 Aug 9.

Recent advances in hidradenitis suppurativa in pediatrics.
Rundle CW, Price KN, Hogeling M, Hsiao JL, Shi VY.
Dermatol Online J. 2020 Dec 15;26(12):13030/qt5gt6m9n3.

γ-Secretase genetics of hidradenitis suppurativa: A systematic literature review.
Wang Z, Yan Y, Wang B.
Dermatology. 2020 Dec 17:1-7. doi: 10.1159/000512455. Online ahead of print.

Race-specific prevalence of hidradenitis suppurativa.
Sachdeva M, Shah M, Alavi A.
J Cutan Med Surg. 2020 Nov 11:1203475420972348. doi: 10.1177/1203475420972348. Online ahead of print.

Cytokine pathways and investigational target therapies in hidradenitis suppurativa.
Del Duca E, Morelli P, Bennardo L, Di Raimondo C, Nisticò SP.
Int J Mol Sci. 2020 Nov 10;21(22):E8436. doi: 10.3390/ijms21228436.

Phenotypes and pathophysiology of syndromic hidradenitis suppurativa: Different faces of the same disease? A systematic review.
Nikolakis G, Kaleta KP, Vaiopoulos AG, Wolter K, Baroud S, Wojas-Pelc A, Zouboulis CC.
Dermatology. 2020 Sep 17:1-25. doi: 10.1159/000509873. Online ahead of print.

A systematic review and critical appraisal of metagenomic and culture studies in hidradenitis suppurativa.
Williams SC, Frew JW, Krueger JG.
Exp Dermatol. 2020 Jul 2. doi: 10.1111/exd.14141. [Epub ahead of print]

Hidradenitis suppurativa: An update on epidemiology, phenotypes, diagnosis, pathogenesis, comorbidities and quality of life.
Nguyen TV, Damiani G, Orenstein LAV, Hamzavi I, Jemec G.
J Eur Acad Dermatol Venereol. 2020 May 27. doi: 10.1111/jdv.16677. [Epub ahead of print]

Hidradenitis suppurativa in pediatric patients: a retrospective monocentric study in Germany and review of the literature.
Vaiopoulos AG, Nikolakis G, Zouboulis CC.
J Eur Acad Dermatol Venereol. 2020 Apr 23. doi: 10.1111/jdv.16520. [Epub ahead of print]

Paradoxical hidradenitis suppurativa in patients receiving TNF-α inhibitors: Case series, systematic review, and case meta-analysis.
Salvador-Rodriguez L, Montero-Vílchez T, Arias-Santiago S, Molina-Leyva A.
Dermatology. 2020 Mar 5:1-7. doi: 10.1159/000506074. [Epub ahead of print]

Hidradenitis suppurativa and smoking: a systematic review and meta-analysis.
Acharya P, Mathur M.
J Am Acad Dermatol. 2019 Oct 31. pii: S0190-9622(19)32967-6. doi: 10.1016/j.jaad.2019.10.044. [Epub ahead of print] 

A scoping review of non-invasive imaging modalities in dermatological disease: potential novel biomarkers in hidradenitis suppurativa.
Grand D, Navrazhina K, Frew JW.
Front Med (Lausanne). 2019 Nov 6;6:253. doi: 10.3389/fmed.2019.00253. eCollection 2019.

Dietary and metabolic factors in the pathogenesis of hidradenitis suppurativa: a systematic review.
Choi F, Lehmer L, Ekelem C, Mesinkovska NA.
Int J Dermatol. 2019 Oct 25. doi: 10.1111/ijd.14691. [Epub ahead of print]

A systematic review and critical evaluation of immunohistochemical associations in hidradenitis suppurativa.
Frew JW, Hawkes JE, Krueger JG.Version 2.
F1000Res. 2018 Dec 11 [revised 2019 Jan 1];7:1923. doi: 10.12688/f1000research.17268.2. eCollection 2018.

A systematic review and critical evaluation of inflammatory cytokine associations in hidradenitis suppurativa.
Frew JW, Hawkes JE, Krueger JG.
F1000Res. 2018 Dec 13;7:1930. doi: 10.12688/f1000research.17267.1. eCollection 2018.

Hidradenitis suppurativa: A systematic review integrating inflammatory pathways into a cohesive pathogenic model.
Vossen ARJV, van der Zee HH, Prens EP.
Front Immunol. 2018 Dec 14;9:2965. doi: 10.3389/fimmu.2018.02965. eCollection 2018.

A systematic literature review of the human skin microbiome as biomarker for dermatological drug development.
Niemeyer-van der Kolk T, van der Wall HEC, Balmforth C, Van Doorn MBA, Rissmann R.
Br J Clin Pharmacol. 2018 Jun 7. doi: 10.1111/bcp.13662. [Epub ahead of print]

Drug-associated hidradenitis suppurativa: A systematic review of case reports.
Frew JW, Vekic DA, Woods JA, Cains GD.
J Am Acad Dermatol. 2018 Jan;78(1):217-219.e2. doi: 10.1016/j.jaad.2017.08.046. No abstract available.

Recognizing syndromic hidradenitis suppurativa: a review of the literature.
Gasparic J, Theut Riis P, Jemec GB.
J Eur Acad Dermatol Venereol. 2017 Nov;31(11):1809-1816. doi: 10.1111/jdv.14464. Epub 2017 Sep 7.

Hidradenitis suppurativa: Advances in diagnosis and treatment.
Saunte DML, Jemec GBE.
JAMA. 2017 Nov 28;318(20):2019-2032. doi: 10.1001/jama.2017.16691.

A systematic review and critical evaluation of reported pathogenic sequence variants in hidradenitis suppurativa.
Frew JW, Vekic DA, Woods J, Cains GD.
Br J Dermatol. 2017 Oct;177(4):987-998. doi: 10.1111/bjd.15441. Epub 2017 Sep 20.

The role of androgens and estrogens in hidradenitis suppurativa – a systematic review.
Riis PT, Ring HC, Themstrup L, Jemec GB.
Acta Dermatovenerol Croat. 2016 Dec;24(4):239-249.

A systematic review of terms used to describe hidradenitis suppurativa.
Freysz M, Jemec GB, Lipsker D.
Br J Dermatol. 2015 Nov;173(5):1298-300. doi: 10.1111/bjd.13940. Epub 2015 Aug 12.

The bacteriology of hidradenitis suppurativa: a systematic review.
Ring HC, Riis Mikkelsen P, Miller IM, Jenssen H, Fuursted K, Saunte DM, Jemec GB.
Exp Dermatol. 2015 Oct;24(10):727-31. doi: 10.1111/exd.12793. Epub 2015 Aug 21.

 

Co-morbidities & sequelae

Recent advances in hidradenitis suppurativa in pediatrics.
Rundle CW, Price KN, Hogeling M, Hsiao JL, Shi VY.
Dermatol Online J. 2020 Dec 15;26(12):13030/qt5gt6m9n3.

Hidradenitis suppurativa and major adverse cardiac events: A systematic review and meta-analysis.
Joseph Bailey AM, Oi-Yee Li H, Tan MG, Kirchhof MG.
J Am Acad Dermatol. 2020 Oct 7:S0190-9622(20)32757-2. doi: 10.1016/j.jaad.2020.10.005. Online ahead of print.

Hidradenitis suppurativa and Down syndrome: A systematic review and meta-analysis.
Lam M, Lai C, Almuhanna N, Alhusayen R.
Pediatr Dermatol. 2020 Sep 6. doi: 10.1111/pde.14326. Online ahead of print.

Hidradenitis suppurativa and psychiatric comorbidities, suicides and substance abuse: systematic review and meta-analysis.
Phan K, Huo YR, Smith SD.
Ann Transl Med. 2020 Jul;8(13):821. doi: 10.21037/atm-20-1028.

Hidradenitis suppurativa: An update on epidemiology, phenotypes, diagnosis, pathogenesis, comorbidities and quality of life.
Nguyen TV, Damiani G, Orenstein LAV, Hamzavi I, Jemec G.
J Eur Acad Dermatol Venereol. 2020 May 27. doi: 10.1111/jdv.16677. [Epub ahead of print]

The prevalence and odds of anxiety and depression in children and adults with hidradenitis suppurativa: systematic review and meta-analyses.
Jalenques I, Ciortianu L, Pereira B, D'Incan M, Lauron S, Rondepierre F.
J Am Acad Dermatol. 2020 Mar 25. pii: S0190-9622(20)30461-8. doi: 10.1016/j.jaad.2020.03.041. [Epub ahead of print]

Hidradenitis suppurativa and thyroid disease: Systematic review and meta-analysis.
Phan K, Huo YR, Charlton O, Smith SD.
J Cutan Med Surg. 2020 Jan/Feb;24(1):23-27. doi: 10.1177/1203475419874411. Epub 2019 Sep 5.

Association between hidradenitis suppurativa, depression, anxiety, and suicidality: A systematic review and meta-analysis.
Patel KR, Lee HH, Rastogi S, Vakharia PP, Hua T, Chhiba K, Singam V, Silverberg JI.
J Am Acad Dermatol. 2019 Dec 17. pii: S0190-9622(19)33299-2. doi: 10.1016/j.jaad.2019.11.068. [Epub ahead of print]

Prevalence of inflammatory bowel disease (IBD) in hidradenitis suppurativa (HS): systematic review and adjusted meta-analysis.
Phan K, Tatian A, Woods J, Cains G, Frew JW.
Int J Dermatol. 2019 Oct 20. doi: 10.1111/ijd.14697. [Epub ahead of print]

Thyroid disorders in patients with hidradenitis suppurativa: a systematic review and meta-analysis.
Acharya P, Mathur M.
J Am Acad Dermatol. 2019 Jul 13. pii: S0190-9622(19)32383-7. doi: 10.1016/j.jaad.2019.07.025. [Epub ahead of print] No abstract available.

Association of hidradenitis suppurativa with inflammatory bowel disease: A systematic review and meta-analysis.
Chen WT, Chi CC.
JAMA Dermatol. 2019 Jul 10. doi: 10.1001/jamadermatol.2019.0891. [Epub ahead of print]

Hidradenitis suppurativa and polycystic ovarian syndrome: Systematic review and meta-analysis.
Phan K, Charlton O, Smith SD.
Australas J Dermatol. 2019 Jul 1. doi: 10.1111/ajd.13110. [Epub ahead of print]

Depression and anxiety in adults with hidradenitis suppurativa: A systematic review and meta-analysis.
Machado MO, Stergiopoulos V, Maes M, Kurdyak PA, Lin PY, Wang LJ, Shyu YC, Firth J, Koyanagi A, Solmi M, Alavi A, Piguet V, Carvalho AF.
JAMA Dermatol. 2019 Jun 5. doi: 10.1001/jamadermatol.2019.0759. [Epub ahead of print]

Hidradenitis suppurativa and metabolic syndrome - systematic review and adjusted meta-analysis.
Phan K, Charlton O, Smith SD.
Int J Dermatol. 2019 May 31. doi: 10.1111/ijd.14500. [Epub ahead of print]

Hidradenitis suppurativa and risk of suicide - systematic review and meta-analysis.
Phan K, Loya A, Ramachandran V, Smith SD.
J Dermatolog Treat. 2019 May 7:1-8. doi: 10.1080/09546634.2019.1613483. [Epub ahead of print]

Association between hidradenitis suppurativa and metabolic syndrome.
Rodríguez-Zuñiga MJM, García-Perdomo HA, Ortega-Loayza AG.
Actas Dermosifiliogr. 2019 Mar 4. pii: S0001-7310(19)30002-X. doi: 10.1016/j.ad.2018.10.020. [Epub ahead of print] English, Spanish. 

Hidradenitis suppurativa and diabetes mellitus: updated systematic review and adjusted meta-analysis.
Phan K, Charlton O, Smith SD.
Clin Exp Dermatol. 2019 Feb 7. doi: 10.1111/ced.13922. [Epub ahead of print]

Hidradenitis suppurativa/acne inversa: A practical framework for treatment optimization - systematic review and recommendations from the HS ALLIANCE working group.
Zouboulis CC, Bechara FG, Dickinson-Blok JL, Gulliver W, Horváth B, Hughes R, Kimball AB, Kirby B, Martorell A, Podda M, Prens EP, Ring HC, Tzellos T, van der Zee HH, van Straalen KR, Vossen ARJV, Jemec GBE.
J Eur Acad Dermatol Venereol. 2018 Sep 3. doi: 10.1111/jdv.15233. [Epub ahead of print]

Lymphedema in patients with hidradenitis suppurativa: a systematic review of published literature.
Micieli R, Alavi A.
Int J Dermatol. 2018 Aug 13. doi: 10.1111/ijd.14173. [Epub ahead of print]

Hidradenitis suppurativa and diabetes mellitus: A systematic review and meta-analysis.
Bui TL, Silva-Hirschberg C, Torres J, Armstrong AW.
J Am Acad Dermatol. 2018 Feb;78(2):395-402. doi: 10.1016/j.jaad.2017.08.042. Epub 2017 Oct 19.

Vulvar, perianal and perineal cancer after hidradenitis suppurativa: A systematic review and pooled analysis.
Makris GM, Poulakaki N, Papanota AM, Kotsifa E, Sergentanis TN, Psaltopoulou T.
Dermatol Surg. 2017 Jan;43(1):107-115. doi: 10.1097/DSS.0000000000000944.

Cardiovascular disease risk factors in patients with hidradenitis suppurativa: a systematic review and meta-analysis of observational studies.
Tzellos T, Zouboulis CC, Gulliver W, Cohen AD, Wolkenstein P, Jemec GB.
Br J Dermatol. 2015 Nov;173(5):1142-55. doi: 10.1111/bjd.14024. Epub 2015 Sep 22.

 

Disease impact

Trends in the management of hidradenitis suppurativa in the Middle East region: a systematic review.
Karvar M, Panayi AC, Alavi A, Baziar Z, Orgill DP.
Int J Dermatol. 2020 Dec 8. doi: 10.1111/ijd.15293. Online ahead of print.

Recent advances in hidradenitis suppurativa in pediatrics.
Rundle CW, Price KN, Hogeling M, Hsiao JL, Shi VY.
Dermatol Online J. 2020 Dec 15;26(12):13030/qt5gt6m9n3.

Sexual impairment in patients with hidradenitis suppurativa: a systematic review.
Cuenca-Barrales C, Montero-Vílchez T, Szepietowski JC, Matusiak L, Molina-Leyva A.
J Eur Acad Dermatol Venereol. 2020 Jun 12. doi: 10.1111/jdv.16726. [Epub ahead of print]

Hidradenitis suppurativa: An update on epidemiology, phenotypes, diagnosis, pathogenesis, comorbidities and quality of life.
Nguyen TV, Damiani G, Orenstein LAV, Hamzavi I, Jemec G.
J Eur Acad Dermatol Venereol. 2020 May 27. doi: 10.1111/jdv.16677. [Epub ahead of print]

The prevalence and odds of anxiety and depression in children and adults with hidradenitis suppurativa: systematic review and meta-analyses.
Jalenques I, Ciortianu L, Pereira B, D'Incan M, Lauron S, Rondepierre F.
J Am Acad Dermatol. 2020 Mar 25. pii: S0190-9622(20)30461-8. doi: 10.1016/j.jaad.2020.03.041. [Epub ahead of print]

Hidradenitis suppurativa in pediatric patients: a retrospective monocentric study in Germany and review of the literature.
Vaiopoulos AG, Nikolakis G, Zouboulis CC.
J Eur Acad Dermatol Venereol. 2020 Apr 23. doi: 10.1111/jdv.16520. [Epub ahead of print]

The prevalence and odds of anxiety and depression in children and adults with hidradenitis suppurativa: systematic review and meta-analyses.
Jalenques I, Ciortianu L, Pereira B, D'Incan M, Lauron S, Rondepierre F.
J Am Acad Dermatol. 2020 Mar 25. pii: S0190-9622(20)30461-8. doi: 10.1016/j.jaad.2020.03.041. [Epub ahead of print]

Association between hidradenitis suppurativa, depression, anxiety, and suicidality: A systematic review and meta-analysis.
Patel KR, Lee HH, Rastogi S, Vakharia PP, Hua T, Chhiba K, Singam V, Silverberg JI.
J Am Acad Dermatol. 2019 Dec 17. pii: S0190-9622(19)33299-2. doi: 10.1016/j.jaad.2019.11.068. [Epub ahead of print]

Depression and anxiety in adults with hidradenitis suppurativa: A systematic review and meta-analysis.
Machado MO, Stergiopoulos V, Maes M, Kurdyak PA, Lin PY, Wang LJ, Shyu YC, Firth J, Koyanagi A, Solmi M, Alavi A, Piguet V, Carvalho AF.
JAMA Dermatol. 2019 Jun 5. doi: 10.1001/jamadermatol.2019.0759. [Epub ahead of print]

Hidradenitis suppurativa and risk of suicide - systematic review and meta-analysis.
Phan K, Loya A, Ramachandran V, Smith SD.
J Dermatolog Treat. 2019 May 7:1-8. doi: 10.1080/09546634.2019.1613483. [Epub ahead of print]

Quality of life of patients with pyoderma gangrenosum and hidradenitis suppurativa.
Gerard AJ, Feldman SR, Strowd L.
J Cutan Med Surg. 2015 Jul-Aug;19(4):391-6. doi: 10.1177/1203475415575013. Epub 2015 Mar 5.

EQ-5D in skin conditions: an assessment of validity and responsiveness.
Yang Y, Brazier J, Longworth L.
Eur J Health Econ. 2015 Dec;16(9):927-39. doi: 10.1007/s10198-014-0638-9. Epub 2014 Oct 31.

 

Outcomes & outcome measures

A narrative review of the definition of "flare" in hidradenitis suppurativa.
Kirby J, Moore B, Leiphart P, Shumaker K, Mammis-Gierbolini A, Benhadou F, Del Marmol V.
Br J Dermatol. 2019 Apr 26. doi: 10.1111/bjd.18035. [Epub ahead of print]

Hidradenitis suppurativa/acne inversa: A practical framework for treatment optimization - systematic review and recommendations from the HS ALLIANCE working group.
Zouboulis CC, Bechara FG, Dickinson-Blok JL, Gulliver W, Horváth B, Hughes R, Kimball AB, Kirby B, Martorell A, Podda M, Prens EP, Ring HC, Tzellos T, van der Zee HH, van Straalen KR, Vossen ARJV, Jemec GBE.
J Eur Acad Dermatol Venereol. 2018 Sep 3. doi: 10.1111/jdv.15233. [Epub ahead of print]

Development of core outcome sets in hidradenitis suppurativa: systematic review of outcome measure instruments to inform the process.
Ingram JR, Hadjieconomou S, Piguet V.
Br J Dermatol. 2016 Aug;175(2):263-72. doi: 10.1111/bjd.14475. Epub 2016 May 2.

 

 

Topical treatments 

Topical antimicrobials

Hidradenitis suppurativa/acne inversa: A practical framework for treatment optimization - systematic review and recommendations from the HS ALLIANCE working group.
Zouboulis CC, Bechara FG, Dickinson-Blok JL, Gulliver W, Horváth B, Hughes R, Kimball AB, Kirby B, Martorell A, Podda M, Prens EP, Ring HC, Tzellos T, van der Zee HH, van Straalen KR, Vossen ARJV, Jemec GBE.
J Eur Acad Dermatol Venereol. 2018 Sep 3. doi: 10.1111/jdv.15233. [Epub ahead of print]

Hidradenitis suppurativa: Advances in diagnosis and treatment.
Saunte DML, Jemec GBE.
JAMA. 2017 Nov 28;318(20):2019-2032. doi: 10.1001/jama.2017.16691.

Interventions for hidradenitis suppurativa: a Cochrane systematic review incorporating GRADE assessment of evidence quality.
Ingram JR, Woo PN, Chua SL, Ormerod AD, Desai N, Kai AC, Hood K, Burton T, Kerdel F, Garner SE, Piguet V.
Br J Dermatol. 2016 May;174(5):970-8. doi: 10.1111/bjd.14418. Epub 2016 Mar 30.

Interventions for hidradenitis suppurativa.
Ingram JR, Woo PN, Chua SL, Ormerod AD, Desai N, Kai AC, Hood K, Burton T, Kerdel F, Garner SE, Piguet V.
Cochrane Database Syst Rev. 2015 Oct 7;(10):CD010081. doi: 10.1002/14651858.CD010081.pub2.

Pharmacologic interventions for hidradenitis suppurativa: what does the evidence say?
Alhusayen R, Shear NH.
Am J Clin Dermatol. 2012 Oct 1;13(5):283-91. doi: 10.2165/11631880-000000000-00000.

A systematic review of treatments for hidradenitis suppurativa.
Rambhatla PV, Lim HW, Hamzavi I.
Arch Dermatol. 2012 Apr;148(4):439-46. doi: 10.1001/archdermatol.2011.1950. Epub 2011 Dec 19.

 

Other topical treatments

Efficacy of topical ichthammol 10% for hidradenitis suppurativa: case series and systematic review of its use in dermatology.
Fisher S, Ziv M.
Dermatol Ther. 2020 Jun 18:e13868. doi: 10.1111/dth.13868. [Epub ahead of print] No abstract available. 

Hidradenitis suppurativa: Advances in diagnosis and treatment.
Saunte DML, Jemec GBE.
JAMA. 2017 Nov 28;318(20):2019-2032. doi: 10.1001/jama.2017.16691.

A systematic review of treatments for hidradenitis suppurativa.
Rambhatla PV, Lim HW, Hamzavi I.
Arch Dermatol. 2012 Apr;148(4):439-46. doi: 10.1001/archdermatol.2011.1950. Epub 2011 Dec 19.

 

 

Systemic treatments

Systemic antimicrobials

Hidradenitis suppurativa: A systematic review and meta-analysis of therapeutic interventions.
Tchero H, Herlin C, Bekara F, Fluieraru S, Teot L.
Indian J Dermatol Venereol Leprol. 2019 Mar 20. doi: 10.4103/ijdvl.IJDVL_69_18. [Epub ahead of print]

Long-term clinical safety of clindamycin and rifampicin combination for the treatment of hidradenitis suppurativa: a critically appraised topic.
Albrecht J, Baine PA, Ladizinski B, Jemec GB, Bigby M.
Br J Dermatol. 2018 Oct 3. doi: 10.1111/bjd.17265. [Epub ahead of print]

Hidradenitis suppurativa/acne inversa: A practical framework for treatment optimization - systematic review and recommendations from the HS ALLIANCE working group.
Zouboulis CC, Bechara FG, Dickinson-Blok JL, Gulliver W, Horváth B, Hughes R, Kimball AB, Kirby B, Martorell A, Podda M, Prens EP, Ring HC, Tzellos T, van der Zee HH, van Straalen KR, Vossen ARJV, Jemec GBE.
J Eur Acad Dermatol Venereol. 2018 Sep 3. doi: 10.1111/jdv.15233. [Epub ahead of print]

Hidradenitis suppurativa: Advances in diagnosis and treatment.
Saunte DML, Jemec GBE.
JAMA. 2017 Nov 28;318(20):2019-2032. doi: 10.1001/jama.2017.16691.

Non-surgical treatments for hidradenitis suppurativa: A systematic review.
Robert E, Bodin F, Paul C, Konstantinou MP, Gall Y, Grolleau JL, Laloze J, Chaput B.
Ann Chir Plast Esthet. 2017 Aug;62(4):274-294. doi: 10.1016/j.anplas.2017.03.012. Epub 2017 Apr 28.

Medical management of hidradenitis suppurativa.
Orenstein LA, Micheletti RG.
Semin Cutan Med Surg. 2017 Jun;36(2):62-66. doi: 10.12788/j.sder.2017.021.

Interventions for hidradenitis suppurativa: a Cochrane systematic review incorporating GRADE assessment of evidence quality.
Ingram JR, Woo PN, Chua SL, Ormerod AD, Desai N, Kai AC, Hood K, Burton T, Kerdel F, Garner SE, Piguet V.
Br J Dermatol. 2016 May;174(5):970-8. doi: 10.1111/bjd.14418. Epub 2016 Mar 30.

Randomized controlled trials for the treatment of hidradenitis suppurativa.
van Rappard DC, Mekkes JR, Tzellos T.
Dermatol Clin. 2016 Jan;34(1):69-80. doi: 10.1016/j.det.2015.08.012.

Interventions for hidradenitis suppurativa.
Ingram JR, Woo PN, Chua SL, Ormerod AD, Desai N, Kai AC, Hood K, Burton T, Kerdel F, Garner SE, Piguet V.
Cochrane Database Syst Rev. 2015 Oct 7;(10):CD010081. doi: 10.1002/14651858.CD010081.pub2.

Pharmacologic interventions for hidradenitis suppurativa: what does the evidence say?
Alhusayen R, Shear NH.
Am J Clin Dermatol. 2012 Oct 1;13(5):283-91. doi: 10.2165/11631880-000000000-00000.

A systematic review of treatments for hidradenitis suppurativa.
Rambhatla PV, Lim HW, Hamzavi I.
Arch Dermatol. 2012 Apr;148(4):439-46. doi: 10.1001/archdermatol.2011.1950. Epub 2011 Dec 19.

 

Systemic immune modulators (conventional, non-biologic)

Hidradenitis suppurativa: A systematic review and meta-analysis of therapeutic interventions.
Tchero H, Herlin C, Bekara F, Fluieraru S, Teot L.
Indian J Dermatol Venereol Leprol. 2019 Mar 20. doi: 10.4103/ijdvl.IJDVL_69_18. [Epub ahead of print]

Non-surgical treatments for hidradenitis suppurativa: A systematic review.
Robert E, Bodin F, Paul C, Konstantinou MP, Gall Y, Grolleau JL, Laloze J, Chaput B.
Ann Chir Plast Esthet. 2017 Aug;62(4):274-294. doi: 10.1016/j.anplas.2017.03.012. Epub 2017 Apr 28.

Systemic therapy with immunosuppressive agents and retinoids in hidradenitis suppurativa: a systematic review.
Blok JL, van Hattem S, Jonkman MF, Horváth B.
Br J Dermatol. 2013 Feb;168(2):243-52. doi: 10.1111/bjd.12104.

Pharmacologic interventions for hidradenitis suppurativa: what does the evidence say?
Alhusayen R, Shear NH.
Am J Clin Dermatol. 2012 Oct 1;13(5):283-91. doi: 10.2165/11631880-000000000-00000.

 

Systemic biologic therapies and targeted immune-modulating drugs

Recent advances in hidradenitis suppurativa in pediatrics.
Rundle CW, Price KN, Hogeling M, Hsiao JL, Shi VY.
Dermatol Online J. 2020 Dec 15;26(12):13030/qt5gt6m9n3.

Anti-drug antibodies to TNF inhibitors in hidradenitis suppurativa: a systematic review.
Lu JD, Milakovic M, Piguet V, Alavi A.
Br J Dermatol. 2020 Oct 2. doi: 10.1111/bjd.19591. Online ahead of print.

A systematic review of promising therapeutic targets in hidradenitis suppurativa: A critical evaluation of mechanistic and clinical relevance.
Frew JW, Marzano AV, Wolk K, Join-Lambert O, Alavi A, Lowes MA, Piguet V.
J Invest Dermatol. 2020 Sep 9:S0022-202X(20)31826-1. doi: 10.1016/j.jid.2020.06.019. Online ahead of print.

Ustekinumab in the treatment of patients with hidradenitis suppurativa: multicenter case series and systematic review.
Montero-Vichez T, Pozo-Román T, Sánchez-Velicia L, Vega-Gutiérrez J, Arias-Santiago S, Molina-Leyva A.
J Dermatolog Treat. 2020 Apr 11:1-15. doi: 10.1080/09546634.2020.1755008. [Epub ahead of print]

Systematic review of immunomodulatory therapies for hidradenitis suppurativa.
Lim SYD, Oon HH.
Biologics. 2019 May 13;13:53-78. doi: 10.2147/BTT.S199862. eCollection 2019.

Hidradenitis suppurativa: A systematic review and meta-analysis of therapeutic interventions.
Tchero H, Herlin C, Bekara F, Fluieraru S, Teot L.
Indian J Dermatol Venereol Leprol. 2019 Mar 20. doi: 10.4103/ijdvl.IJDVL_69_18. [Epub ahead of print]

Hidradenitis suppurativa/acne inversa: A practical framework for treatment optimization - systematic review and recommendations from the HS ALLIANCE working group.
Zouboulis CC, Bechara FG, Dickinson-Blok JL, Gulliver W, Horváth B, Hughes R, Kimball AB, Kirby B, Martorell A, Podda M, Prens EP, Ring HC, Tzellos T, van der Zee HH, van Straalen KR, Vossen ARJV, Jemec GBE.
J Eur Acad Dermatol Venereol. 2018 Sep 3. doi: 10.1111/jdv.15233. [Epub ahead of print]

Hidradenitis suppurativa: Advances in diagnosis and treatment.
Saunte DML, Jemec GBE.
JAMA. 2017 Nov 28;318(20):2019-2032. doi: 10.1001/jama.2017.16691.

Targeted treatments for hidradenitis suppurativa: a review of the current literature and ongoing clinical trials.
Maarouf M, Clark AK, Lee DE, Shi VY.
J Dermatolog Treat. 2018 Aug;29(5):441-449. doi: 10.1080/09546634.2017.1395806. Epub 2017 Nov 10.

Adalimumab for treating moderate-to-severe hidradenitis suppurativa: An evidence review group perspective of a NICE single technology appraisal.
Tappenden P, Carroll C, Stevens JW, Rawdin A, Grimm S, Clowes M, Kaltenthaler E, Ingram JR, Collier F, Ghazavi M.
Pharmacoeconomics. 2017 Aug;35(8):805-815. doi: 10.1007/s40273-017-0488-2.

Non-surgical treatments for hidradenitis suppurativa: A systematic review.
Robert E, Bodin F, Paul C, Konstantinou MP, Gall Y, Grolleau JL, Laloze J, Chaput B.
Ann Chir Plast Esthet. 2017 Aug;62(4):274-294. doi: 10.1016/j.anplas.2017.03.012. Epub 2017 Apr 28.

Medical management of hidradenitis suppurativa.
Orenstein LA, Micheletti RG.
Semin Cutan Med Surg. 2017 Jun;36(2):62-66. doi: 10.12788/j.sder.2017.021.

What heals hidradenitis suppurativa: Surgery, immunosuppression, or both?
Falola RA, DeFazio MV, Anghel EL, Mitnick CD, Attinger CE, Evans KK.
Plast Reconstr Surg. 2016 Sep;138(3 Suppl):219S-29S. doi: 10.1097/PRS.0000000000002671.

New treatment strategies for hidradenitis suppurativa.
Andersen R, Jemec GB.
Drugs Today (Barc). 2016 Aug;52(8):439-451

Interventions for hidradenitis suppurativa: a Cochrane systematic review incorporating GRADE assessment of evidence quality.
Ingram JR, Woo PN, Chua SL, Ormerod AD, Desai N, Kai AC, Hood K, Burton T, Kerdel F, Garner SE, Piguet V.
Br J Dermatol. 2016 May;174(5):970-8. doi: 10.1111/bjd.14418. Epub 2016 Mar 30.

Randomized controlled trials for the treatment of hidradenitis suppurativa.
van Rappard DC, Mekkes JR, Tzellos T.
Dermatol Clin. 2016 Jan;34(1):69-80. doi: 10.1016/j.det.2015.08.012.

Interventions for hidradenitis suppurativa.
Ingram JR, Woo PN, Chua SL, Ormerod AD, Desai N, Kai AC, Hood K, Burton T, Kerdel F, Garner SE, Piguet V.
Cochrane Database Syst Rev. 2015 Oct 7;(10):CD010081. doi: 10.1002/14651858.CD010081.pub2.

Systematic review of the efficacy and adverse events associated with infliximab treatment of hidradenitis suppurativa in patients with coexistent inflammatory diseases.
Machet L, Samimi M, Delage M, Paintaud G, Maruani A.
J Am Acad Dermatol. 2013 Oct;69(4):649-50. doi: 10.1016/j.jaad.2013.04.032. 

Impact of TNF-α antagonists on the quality of life in selected skin diseases.
Gisondi P, Girolomoni G.
G Ital Dermatol Venereol. 2013 Jun;148(3):243-8. 

The off-label treatment of severe hidradenitis suppurativa with TNF-α inhibitors: a systematic review.
van Rappard DC, Limpens J, Mekkes JR.
J Dermatolog Treat. 2013 Oct;24(5):392-404. doi: 10.3109/09546634.2012.674193. Epub 2012 Apr 12.

Systemic therapy with immunosuppressive agents and retinoids in hidradenitis suppurativa: a systematic review.
Blok JL, van Hattem S, Jonkman MF, Horváth B.
Br J Dermatol. 2013 Feb;168(2):243-52. doi: 10.1111/bjd.12104.

Pharmacologic interventions for hidradenitis suppurativa: what does the evidence say?
Alhusayen R, Shear NH.
Am J Clin Dermatol. 2012 Oct 1;13(5):283-91. doi: 10.2165/11631880-000000000-00000.

A systematic review of treatments for hidradenitis suppurativa.
Rambhatla PV, Lim HW, Hamzavi I.
Arch Dermatol. 2012 Apr;148(4):439-46. doi: 10.1001/archdermatol.2011.1950. Epub 2011 Dec 19.

Treatment of hidradenitis suppurativa with tumour necrosis factor-alpha inhibitors.
Haslund P, Lee RA, Jemec GB.
Acta Derm Venereol. 2009 Nov;89(6):595-600. doi: 10.2340/00015555-0747.

 

Systemic retinoids

Oral isotretinoin for the treatment of dermatologic conditions other than acne: a systematic review and discussion of future directions.
Chu S, Michelle L, Ekelem C, Sung CT, Rojek N, Mesinkovska NA.
Arch Dermatol Res. 2020 Nov 5. doi: 10.1007/s00403-020-02152-4. Online ahead of print.

Hidradenitis suppurativa: A systematic review and meta-analysis of therapeutic interventions.
Tchero H, Herlin C, Bekara F, Fluieraru S, Teot L.
Indian J Dermatol Venereol Leprol. 2019 Mar 20. doi: 10.4103/ijdvl.IJDVL_69_18. [Epub ahead of print]

Non-surgical treatments for hidradenitis suppurativa: A systematic review.
Robert E, Bodin F, Paul C, Konstantinou MP, Gall Y, Grolleau JL, Laloze J, Chaput B.
Ann Chir Plast Esthet. 2017 Aug;62(4):274-294. doi: 10.1016/j.anplas.2017.03.012. Epub 2017 Apr 28.

Systemic therapy with immunosuppressive agents and retinoids in hidradenitis suppurativa: a systematic review.
Blok JL, van Hattem S, Jonkman MF, Horváth B.
Br J Dermatol. 2013 Feb;168(2):243-52. doi: 10.1111/bjd.12104.

Pharmacologic interventions for hidradenitis suppurativa: what does the evidence say?
Alhusayen R, Shear NH.
Am J Clin Dermatol. 2012 Oct 1;13(5):283-91. doi: 10.2165/11631880-000000000-00000.

A systematic review of treatments for hidradenitis suppurativa.
Rambhatla PV, Lim HW, Hamzavi I.
Arch Dermatol. 2012 Apr;148(4):439-46. doi: 10.1001/archdermatol.2011.1950. Epub 2011 Dec 19.

 

Hormones, anti-androgens and insulin-sensitising drugs

Recent advances in hidradenitis suppurativa in pediatrics.
Rundle CW, Price KN, Hogeling M, Hsiao JL, Shi VY.
Dermatol Online J. 2020 Dec 15;26(12):13030/qt5gt6m9n3.

Oral metformin for treating dermatological diseases: A systematic review.
Sung CT, Chao T, Lee A, Foulad DP, Choi F, Juhasz M, Dobry A, Mesinkovska NA.
J Drugs Dermatol. 2020 Aug 1;19(8):713-720. doi: 10.36849/JDD.2020.4874.

Is there a role for antiandrogen therapy for hidradenitis suppurativa? A systematic review of published data.
Nikolakis G, Kyrgidis A, Zouboulis CC.
Am J Clin Dermatol. 2019 May 9. doi: 10.1007/s40257-019-00442-w. [Epub ahead of print]

Hidradenitis suppurativa: A systematic review and meta-analysis of therapeutic interventions.
Tchero H, Herlin C, Bekara F, Fluieraru S, Teot L.
Indian J Dermatol Venereol Leprol. 2019 Mar 20. doi: 10.4103/ijdvl.IJDVL_69_18. [Epub ahead of print]

Hidradenitis suppurativa: Advances in diagnosis and treatment.
Saunte DML, Jemec GBE.
JAMA. 2017 Nov 28;318(20):2019-2032. doi: 10.1001/jama.2017.16691.

Non-surgical treatments for hidradenitis suppurativa: A systematic review.
Robert E, Bodin F, Paul C, Konstantinou MP, Gall Y, Grolleau JL, Laloze J, Chaput B.
Ann Chir Plast Esthet. 2017 Aug;62(4):274-294. doi: 10.1016/j.anplas.2017.03.012. Epub 2017 Apr 28.

Medical management of hidradenitis suppurativa.
Orenstein LA, Micheletti RG.
Semin Cutan Med Surg. 2017 Jun;36(2):62-66. doi: 10.12788/j.sder.2017.021.

Interventions for hidradenitis suppurativa: a Cochrane systematic review incorporating GRADE assessment of evidence quality.
Ingram JR, Woo PN, Chua SL, Ormerod AD, Desai N, Kai AC, Hood K, Burton T, Kerdel F, Garner SE, Piguet V.
Br J Dermatol. 2016 May;174(5):970-8. doi: 10.1111/bjd.14418. Epub 2016 Mar 30.

Interventions for hidradenitis suppurativa.
Ingram JR, Woo PN, Chua SL, Ormerod AD, Desai N, Kai AC, Hood K, Burton T, Kerdel F, Garner SE, Piguet V.
Cochrane Database Syst Rev. 2015 Oct 7;(10):CD010081. doi: 10.1002/14651858.CD010081.pub2.

Pharmacologic interventions for hidradenitis suppurativa: what does the evidence say?
Alhusayen R, Shear NH.
Am J Clin Dermatol. 2012 Oct 1;13(5):283-91. doi: 10.2165/11631880-000000000-00000.

A systematic review of treatments for hidradenitis suppurativa.
Rambhatla PV, Lim HW, Hamzavi I.
Arch Dermatol. 2012 Apr;148(4):439-46. doi: 10.1001/archdermatol.2011.1950. Epub 2011 Dec 19.

 

Intralesional treatments

Hidradenitis suppurativa: Advances in diagnosis and treatment.
Saunte DML, Jemec GBE.
JAMA. 2017 Nov 28;318(20):2019-2032. doi: 10.1001/jama.2017.16691.

 

Other systemic and dietary treatments

Radiotherapy for hidradenitis suppurativa: A systematic review.
Thompson AM, Seivright J, Atluri S, Ederle A, Jaros J, Hsiao JL, Shi VY.
Dermatology. 2021 Feb 3:1-8. doi: 10.1159/000514027. Online ahead of print.

Effects of zinc supplementation on inflammatory skin diseases: a systematic review of the clinical evidence.
Dhaliwal S, Nguyen M, Vaughn AR, Notay M, Chambers CJ, Sivamani RK.
Am J Clin Dermatol. 2019 Nov 19. doi: 10.1007/s40257-019-00484-0. [Epub ahead of print]

Dietary and metabolic factors in the pathogenesis of hidradenitis suppurativa: a systematic review.
Choi F, Lehmer L, Ekelem C, Mesinkovska NA.
Int J Dermatol. 2019 Oct 25. doi: 10.1111/ijd.14691. [Epub ahead of print]

Weight loss and dietary interventions for hidradenitis suppurativa: A systematic review.
Sivanand A, Gulliver WP, Josan CK, Alhusayen R, Fleming PJ.
J Cutan Med Surg. 2019 Sep 10:1203475419874412. doi: 10.1177/1203475419874412. [Epub ahead of print]

Non-pharmacologic approaches for hidradenitis suppurativa - A systematic review.
Hendricks AJ, Hirt PA, Sekhon S, Vaughn AR, Lev-Tov HA, Hsiao JL, Shi VY.
J Dermatolog Treat. 2019 May 20:1-30. doi: 10.1080/09546634.2019.1621981. [Epub ahead of print]

Non-surgical treatments for hidradenitis suppurativa: A systematic review.
Robert E, Bodin F, Paul C, Konstantinou MP, Gall Y, Grolleau JL, Laloze J, Chaput B.
Ann Chir Plast Esthet. 2017 Aug;62(4):274-294. doi: 10.1016/j.anplas.2017.03.012. Epub 2017 Apr 28.

Interventions for hidradenitis suppurativa: a Cochrane systematic review incorporating GRADE assessment of evidence quality.
Ingram JR, Woo PN, Chua SL, Ormerod AD, Desai N, Kai AC, Hood K, Burton T, Kerdel F, Garner SE, Piguet V.
Br J Dermatol. 2016 May;174(5):970-8. doi: 10.1111/bjd.14418. Epub 2016 Mar 30.

Interventions for hidradenitis suppurativa.
Ingram JR, Woo PN, Chua SL, Ormerod AD, Desai N, Kai AC, Hood K, Burton T, Kerdel F, Garner SE, Piguet V.
Cochrane Database Syst Rev. 2015 Oct 7;(10):CD010081. doi: 10.1002/14651858.CD010081.pub2.

Pharmacologic interventions for hidradenitis suppurativa: what does the evidence say?
Alhusayen R, Shear NH.
Am J Clin Dermatol. 2012 Oct 1;13(5):283-91. doi: 10.2165/11631880-000000000-00000.

A systematic review of treatments for hidradenitis suppurativa.
Rambhatla PV, Lim HW, Hamzavi I.
Arch Dermatol. 2012 Apr;148(4):439-46. doi: 10.1001/archdermatol.2011.1950. Epub 2011 Dec 19.

 

 

Surgical interventions

Surgery

Current surgical management of hidradenitis suppurativa: A systematic review and meta-analysis.
Riddle A, Westerkam L, Feltner C, Sayed C.
Dermatol Surg. 2021 Jan 11. doi: 10.1097/DSS.0000000000002892. Online ahead of print.

Office-based surgical intervention for hidradenitis suppurativa (HS): A focused review for dermatologists.
Saylor DK, Brownstone ND, Naik HB.
Dermatol Ther (Heidelb). 2020 May 20. doi: 10.1007/s13555-020-00391-x. [Epub ahead of print]

Recurrence rates following excision of hidradenitis suppurativa: A systematic review and meta-analysis.
Ovadja ZN, Jacobs W, Zugaj M, van der Horst CMAM, Lapid O.
Dermatol Surg. 2020 Mar 31. doi: 10.1097/DSS.0000000000002403. [Epub ahead of print]

Systematic review of complications and recurrences after surgical interventions in hidradenitis suppurativa.
Bouazzi D, Chafranska L, Saunte DML, Jemec GBE.
Dermatol Surg. 2020 Feb 11. doi: 10.1097/DSS.0000000000002323. [Epub ahead of print]

Hidradenitis suppurativa: A systematic review and meta-analysis of therapeutic interventions.
Tchero H, Herlin C, Bekara F, Fluieraru S, Teot L.
Indian J Dermatol Venereol Leprol. 2019 Mar 20. doi: 10.4103/ijdvl.IJDVL_69_18. [Epub ahead of print]

Hidradenitis suppurativa/acne inversa: A practical framework for treatment optimization - systematic review and recommendations from the HS ALLIANCE working group.
Zouboulis CC, Bechara FG, Dickinson-Blok JL, Gulliver W, Horváth B, Hughes R, Kimball AB, Kirby B, Martorell A, Podda M, Prens EP, Ring HC, Tzellos T, van der Zee HH, van Straalen KR, Vossen ARJV, Jemec GBE.
J Eur Acad Dermatol Venereol. 2018 Sep 3. doi: 10.1111/jdv.15233. [Epub ahead of print]

Hidradenitis suppurativa: Advances in diagnosis and treatment.
Saunte DML, Jemec GBE.
JAMA. 2017 Nov 28;318(20):2019-2032. doi: 10.1001/jama.2017.16691.

What heals hidradenitis suppurativa: Surgery, immunosuppression, or both?
Falola RA, DeFazio MV, Anghel EL, Mitnick CD, Attinger CE, Evans KK.
Plast Reconstr Surg. 2016 Sep;138(3 Suppl):219S-29S. doi: 10.1097/PRS.0000000000002671.

Randomized controlled trials for the treatment of hidradenitis suppurativa.
van Rappard DC, Mekkes JR, Tzellos T.
Dermatol Clin. 2016 Jan;34(1):69-80. doi: 10.1016/j.det.2015.08.012.

Recurrence of hidradenitis suppurativa after surgical management: A systematic review and meta-analysis.
Mehdizadeh A, Hazen PG, Bechara FG, Zwingerman N, Moazenzadeh M, Bashash M, Sibbald RG, Alavi A.
J Am Acad Dermatol. 2015 Nov;73(5 Suppl 1):S70-7. doi: 10.1016/j.jaad.2015.07.044.

A systematic review of treatments for hidradenitis suppurativa.
Rambhatla PV, Lim HW, Hamzavi I.
Arch Dermatol. 2012 Apr;148(4):439-46. doi: 10.1001/archdermatol.2011.1950. Epub 2011 Dec 19.

 

Medical and surgical combination therapy

Hidradenitis suppurativa: A systematic review and meta-analysis of therapeutic interventions.
Tchero H, Herlin C, Bekara F, Fluieraru S, Teot L.
Indian J Dermatol Venereol Leprol. 2019 Mar 20. doi: 10.4103/ijdvl.IJDVL_69_18. [Epub ahead of print]

Hidradenitis suppurativa/acne inversa: A practical framework for treatment optimization - systematic review and recommendations from the HS ALLIANCE working group.
Zouboulis CC, Bechara FG, Dickinson-Blok JL, Gulliver W, Horváth B, Hughes R, Kimball AB, Kirby B, Martorell A, Podda M, Prens EP, Ring HC, Tzellos T, van der Zee HH, van Straalen KR, Vossen ARJV, Jemec GBE.
J Eur Acad Dermatol Venereol. 2018 Sep 3. doi: 10.1111/jdv.15233. [Epub ahead of print]

Hidradenitis suppurativa: Advances in diagnosis and treatment.
Saunte DML, Jemec GBE.
JAMA. 2017 Nov 28;318(20):2019-2032. doi: 10.1001/jama.2017.16691.

What heals hidradenitis suppurativa: Surgery, immunosuppression, or both?
Falola RA, DeFazio MV, Anghel EL, Mitnick CD, Attinger CE, Evans KK.
Plast Reconstr Surg. 2016 Sep;138(3 Suppl):219S-29S. doi: 10.1097/PRS.0000000000002671.

Randomized controlled trials for the treatment of hidradenitis suppurativa.
van Rappard DC, Mekkes JR, Tzellos T.
Dermatol Clin. 2016 Jan;34(1):69-80. doi: 10.1016/j.det.2015.08.012.

 

 

Lasers & phototherapy

Lasers

Outcomes and adverse effects of ablative versus nonablative lasers for skin resurfacing: A systematic review of 1093 patients.
Mirza HN, Mirza FN, Khatri KA.
Dermatol Ther. 2020 Oct 20. doi: 10.1111/dth.14432. Online ahead of print.

Systematic review of light-based treatments for hidradenitis suppurativa.
Gracia Cazaña T, Berdel Díaz LV, Martín Sánchez JI, Querol Nasarre I, Gilaberte Y.
Actas Dermosifiliogr. 2019 Dec 20. pii: S0001-7310(19)30371-0. doi: 10.1016/j.ad.2019.04.008. [Epub ahead of print] Review. English, Spanish.

Hidradenitis suppurativa: A systematic review and meta-analysis of therapeutic interventions.
Tchero H, Herlin C, Bekara F, Fluieraru S, Teot L.
Indian J Dermatol Venereol Leprol. 2019 Mar 20. doi: 10.4103/ijdvl.IJDVL_69_18. [Epub ahead of print]

Hidradenitis suppurativa: Advances in diagnosis and treatment.
Saunte DML, Jemec GBE.
JAMA. 2017 Nov 28;318(20):2019-2032. doi: 10.1001/jama.2017.16691.

Non-surgical treatments for hidradenitis suppurativa: A systematic review.
Robert E, Bodin F, Paul C, Konstantinou MP, Gall Y, Grolleau JL, Laloze J, Chaput B.
Ann Chir Plast Esthet. 2017 Aug;62(4):274-294. doi: 10.1016/j.anplas.2017.03.012. Epub 2017 Apr 28.

A systematic review of the use of lasers for the treatment of hidradenitis suppurativa.
John H, Manoloudakis N, Stephen Sinclair J.
J Plast Reconstr Aesthet Surg. 2016 Oct;69(10):1374-81. doi: 10.1016/j.bjps.2016.05.029. Epub 2016 Jun 27.

Interventions for hidradenitis suppurativa: a Cochrane systematic review incorporating GRADE assessment of evidence quality.
Ingram JR, Woo PN, Chua SL, Ormerod AD, Desai N, Kai AC, Hood K, Burton T, Kerdel F, Garner SE, Piguet V.
Br J Dermatol. 2016 May;174(5):970-8. doi: 10.1111/bjd.14418. Epub 2016 Mar 30.

Randomized controlled trials for the treatment of hidradenitis suppurativa.
van Rappard DC, Mekkes JR, Tzellos T.
Dermatol Clin. 2016 Jan;34(1):69-80. doi: 10.1016/j.det.2015.08.012.

Interventions for hidradenitis suppurativa.
Ingram JR, Woo PN, Chua SL, Ormerod AD, Desai N, Kai AC, Hood K, Burton T, Kerdel F, Garner SE, Piguet V.
Cochrane Database Syst Rev. 2015 Oct 7;(10):CD010081. doi: 10.1002/14651858.CD010081.pub2.

A systematic review of treatments for hidradenitis suppurativa.
Rambhatla PV, Lim HW, Hamzavi I.
Arch Dermatol. 2012 Apr;148(4):439-46. doi: 10.1001/archdermatol.2011.1950. Epub 2011 Dec 19.

 

Intense pulsed light

Systematic review of light-based treatments for hidradenitis suppurativa.
Gracia Cazaña T, Berdel Díaz LV, Martín Sánchez JI, Querol Nasarre I, Gilaberte Y.
Actas Dermosifiliogr. 2019 Dec 20. pii: S0001-7310(19)30371-0. doi: 10.1016/j.ad.2019.04.008. [Epub ahead of print] Review. English, Spanish.

Hidradenitis suppurativa/acne inversa: A practical framework for treatment optimization - systematic review and recommendations from the HS ALLIANCE working group.
Zouboulis CC, Bechara FG, Dickinson-Blok JL, Gulliver W, Horváth B, Hughes R, Kimball AB, Kirby B, Martorell A, Podda M, Prens EP, Ring HC, Tzellos T, van der Zee HH, van Straalen KR, Vossen ARJV, Jemec GBE.
J Eur Acad Dermatol Venereol. 2018 Sep 3. doi: 10.1111/jdv.15233. [Epub ahead of print]

Interventions for hidradenitis suppurativa: a Cochrane systematic review incorporating GRADE assessment of evidence quality.
Ingram JR, Woo PN, Chua SL, Ormerod AD, Desai N, Kai AC, Hood K, Burton T, Kerdel F, Garner SE, Piguet V.
Br J Dermatol. 2016 May;174(5):970-8. doi: 10.1111/bjd.14418. Epub 2016 Mar 30.

Interventions for hidradenitis suppurativa.
Ingram JR, Woo PN, Chua SL, Ormerod AD, Desai N, Kai AC, Hood K, Burton T, Kerdel F, Garner SE, Piguet V.
Cochrane Database Syst Rev. 2015 Oct 7;(10):CD010081. doi: 10.1002/14651858.CD010081.pub2.

 

Photodynamic therapy & other light-based treatments

The efficacy and effectiveness of non-ablative light-based devices in hidradenitis suppurativa: A systematic review and meta-analysis.
Jfri A, Saxena A, Rouette J, Netchiporouk E, Barolet A, O'Brien E, Barolet D, Litvinov IV.
Front Med (Lausanne). 2020 Nov 3;7:591580. doi: 10.3389/fmed.2020.591580. eCollection 2020.

Systematic review of light-based treatments for hidradenitis suppurativa.
Gracia Cazaña T, Berdel Díaz LV, Martín Sánchez JI, Querol Nasarre I, Gilaberte Y.
Actas Dermosifiliogr. 2019 Dec 20. pii: S0001-7310(19)30371-0. doi: 10.1016/j.ad.2019.04.008. [Epub ahead of print] Review. English, Spanish.

Hidradenitis suppurativa/acne inversa: A practical framework for treatment optimization - systematic review and recommendations from the HS ALLIANCE working group.
Zouboulis CC, Bechara FG, Dickinson-Blok JL, Gulliver W, Horváth B, Hughes R, Kimball AB, Kirby B, Martorell A, Podda M, Prens EP, Ring HC, Tzellos T, van der Zee HH, van Straalen KR, Vossen ARJV, Jemec GBE.
J Eur Acad Dermatol Venereol. 2018 Sep 3. doi: 10.1111/jdv.15233. [Epub ahead of print]

Non-surgical treatments for hidradenitis suppurativa: A systematic review.
Robert E, Bodin F, Paul C, Konstantinou MP, Gall Y, Grolleau JL, Laloze J, Chaput B.
Ann Chir Plast Esthet. 2017 Aug;62(4):274-294. doi: 10.1016/j.anplas.2017.03.012. Epub 2017 Apr 28.

Interventions for hidradenitis suppurativa: a Cochrane systematic review incorporating GRADE assessment of evidence quality.
Ingram JR, Woo PN, Chua SL, Ormerod AD, Desai N, Kai AC, Hood K, Burton T, Kerdel F, Garner SE, Piguet V.
Br J Dermatol. 2016 May;174(5):970-8. doi: 10.1111/bjd.14418. Epub 2016 Mar 30.

Interventions for hidradenitis suppurativa.
Ingram JR, Woo PN, Chua SL, Ormerod AD, Desai N, Kai AC, Hood K, Burton T, Kerdel F, Garner SE, Piguet V.
Cochrane Database Syst Rev. 2015 Oct 7;(10):CD010081. doi: 10.1002/14651858.CD010081.pub2.

A systematic review of treatments for hidradenitis suppurativa.
Rambhatla PV, Lim HW, Hamzavi I.
Arch Dermatol. 2012 Apr;148(4):439-46. doi: 10.1001/archdermatol.2011.1950. Epub 2011 Dec 19.

 

 

Centre of Evidence Based Dermatology

The University of Nottingham
King's Meadow Campus
Lenton Lane
Nottingham, NG7 2NR


telephone: +44 (0) 115 823 1048
email:cebd@nottingham.ac.uk