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Systematic reviews on vitiligo

March 2021: This resource is now archived and no longer being updated.

We recommend the Epistemonikos database as a comprehensive, searchable database of systematic reviews. 

This page is a mapping by topic of systematic reviews on vitiligo, based on searches of PubMed and other sources. Links are given to the PubMed abstract, or the original publication if not in PubMed.

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Vitiligo

 

Copyright © 2021 The University of Nottingham, on behalf of the Centre of Evidence Based Dermatology. ALL RIGHTS RESERVED.
Please reference this resource (as a web page citation) if you use it for research or publications.

 

Epidemiology and aetiology

Prevalence
 

Aetiology & risk factors

2020 Associations of methylenetetrahydrofolate reductase gene (MTHFR) rs1801131 and rs1801133 polymorphisms with susceptibility to vitiligo: A meta-analysis

2020 Selenium level in patients with vitiligo: A meta-analysis

2020 Associations of angiotensin-converting enzyme gene insertion/deletion (ACE Gene I/D) polymorphism with vitiligo: An updated systematic review and meta-analysis

2020 Serum level of antioxidant vitamins and minerals in patients with vitiligo, a systematic review and meta-analysis

2020 Interleukin-17 level in patients with vitiligo: A systematic review and meta-analysis

2019 Association of PTPN22 1858C/T polymorphism with autoimmune diseases: A systematic review and Bayesian approach

2018 Serum homocysteine, folate, and vitamin B12 levels in patients with vitiligo and their potential roles as disease activity biomarkers: A systematic review and meta-analysis

2018 Vitamin D receptor gene polymorphism, serum 25-hydroxyvitamin D levels, and risk of vitiligo: A meta-analysis

2018 The role of interleukins in vitiligo: A systematic review

2018 Critical appraisal of the oxidative stress pathway in vitiligo: a systematic review and meta-analysis

2017 Association of protein tyrosine phosphatase, non-receptor type 22 +1858C→T polymorphism and susceptibility to vitiligo: Systematic review and meta-analysis

2016 Meta-analysis of the association between vitiligo and the level of superoxide dismutase or malondialdehyde

2016 Meta-analysis of the association between vitiligo and human leukocyte antigen-A

2016 Glutathione peroxidase level in patients with vitiligo: a meta-analysis

2016 Low 25-hydroxyvitamin D levels are associated with vitiligo: a systematic review and meta-analysis

2015 Meta-analysis of the TNF-α-308G/A polymorphism and vitiligo risk

2015 The association between tumor necrosis factor-α-308 G/A polymorphism and risk for vitiligo: a meta-analysis

2015 Associations between TNF-α polymorphisms and susceptibility to rheumatoid arthritis and vitiligo: a meta-analysis

2015 Lack of association between cytotoxic T-lymphocyte antigen-4+49A/G polymorphism and psoriasis and vitiligo: A meta-analysis of case-control studies

2015 Association of Apal and Bsml polymorphisms with vitiligo risk: a meta-analysis

2015 Lack of association between the 389C>T polymorphism (rs769217) in the catalase (CAT) gene and the risk of vitiligo: an update by meta-analysis

2015 Interventions for vitiligo (Cochrane Review)

2014 Association of the 389 C/T polymorphism of the catalase gene with susceptibility to vitiligo: a meta-analysis

2014 Association of glutathione S-transferase M1/T1 polymorphisms with susceptibility to vitiligo

2014 Decreased copper and zinc in sera of Chinese vitiligo patients: a meta-analysis

2013 Association of ACE gene I/D polymorphism with vitiligo: a meta-analysis

2013 The angiotensin-converting enzyme gene insertion/deletion polymorphism in Indian patients with vitiligo: a case-control study and meta-analysis

2013 The CTLA-4 +49 A/G, CT60 A/G and PTPN22 1858 C/T polymorphisms and susceptibility to vitiligo: a meta-analysis

2012 Meta-analysis reveals an association of PTPN22 C1858T with autoimmune diseases, which depends on the localization of the affected tissue

2012 Genome-wide association analyses identify 13 new susceptibility loci for generalized vitiligo

2011 The polymorphism of catalase T/C codon 389 in exon 9 and vitiligo susceptibility: a meta-analysis

2009 CTLA4 and generalized vitiligo: two genetic association studies and a meta-analysis of published data

2007 Association of vitiligo with HLA-A2: a meta-analysis

 

Co-morbidities

2020 Association between vitiligo and hearing loss: A systemic review and meta-analysis

2020 Vitiligo and anxiety: A systematic review and meta-analysis

2020 Association of multiple sclerosis with vitiligo: a systematic review and meta-analysis

2019 Association of atopic dermatitis with vitiligo: A systematic review and meta-analysis

2019 The association between vitiligo and diabetes mellitus: A systematic review and meta-analysis

2019 The prevalence of thyroid disorders in patients with vitiligo: a systematic review and meta-analysis

2019 Associated auto-immune disease in type 1 diabetes patients: a systematic review and meta-analysis

2018 Vitiligo and thyroid disease: a systematic review and meta-analysis

2018 Association between psoriasis and vitiligo: A systematic review and meta-analysis

2018 Vitiligo and autoantibodies: a systematic review and meta-analysis

2018 Risk of skin cancer in people with vitiligo: a systematic review and meta-analysis

2017 The prevalence and odds of depression in patients with vitiligo: A meta-analysis

2017 The prevalence of psychological co-morbidity in people with vitiligo: a systematic review and meta-analysis

2017 Skin manifestations associated with autoimmune liver diseases: A systematic review

2017 Autoimmune diseases involving skin and intestinal mucosa are more frequent in adolescents and young adults suffering from atopic dermatitis

2017 Hearing loss in vitiligo: current concepts and review

2016 Vitiligo and depression: A systematic review and meta-analysis of observational studies

2015 Association of vitiligo and alopecia areata with atopic dermatitis: a systematic review and meta-analysis

2015 Interventions for vitiligo (Cochrane Review)

2012 The prevalence of thyroid disease in patients with vitiligo: a systematic review

2012 The coexistence of psoriasis and vitiligo: a review

2008 Alexithymia and dermatology: the state of the art

 

Diagnosis & evaluation
 

Disease impact & treatment cost-effectiveness
 

Topical treatments 

Topical corticosteroids
 

Topical calcineurin inhibitors

2020 The effects of tacrolimus plus phototherapy in the treatment of vitiligo: a meta-analysis

2020 Efficacy of combination therapy of narrowband-ultraviolet B phototherapy or excimer laser with topical tacrolimus for vitiligo: An updated systematic review and meta-analysis

2019 The effectiveness of topical calcineurin inhibitors comparing with topical corticosteroids in the treatment of vitiligo: a systematic review and meta-analysis

2019 The efficacy and safety of tacrolimus as mono- and adjunctive therapy for vitiligo: A systematic review of randomised clinical trials

2019 Treatment outcomes of topical calcineurin inhibitor therapy for patients with vitiligo: a systematic review and meta-analysis

2016 Pharmacologic treatment of vitiligo in children and adolescents: a systematic review

2016 Effect of narrow band ultraviolet B phototherapy as monotherapy or combination therapy for vitiligo: a meta-analysis

2016 Evidence-based management of vitiligo: summary of a Cochrane systematic review

2016 The efficacy of 308-nm excimer laser/light (EL) and topical agent combination therapy versus EL monotherapy for vitiligo: A systematic review and meta-analysis of randomized controlled trials (RCTs)

2016 Effectiveness and safety of topical tacrolimus monotherapy for repigmentation in vitiligo: a comprehensive literature review

2016 Effect of topical calcineurin inhibitors as monotherapy or combined with phototherapy for vitiligo treatment: a meta-analysis

2015 Interventions for vitiligo (Cochrane Review)

2012 Evidence-based, non-surgical treatments for vitiligo: a review

2011 Vitiligo in adults and children (BMJ Clinical Evidence)

2008 Therapeutic interventions for vitiligo

 

Topical vitamin D analogues
 

Topical pseudocatalase/dismutase superoxide
 

Topical 5-fluorouracil
 
Platelet-rich plasma
 

Topical melagenina
 
Topical Janus kinase (JAK) inhibitors
 

Note: Other topical treatments used in combination therapies are included under "Phototherapy"


Systemic treatments

Oral corticosteroids

2016 Interventions for vitiligo (summary of Cochrane Review)

2015 Interventions for vitiligo (Cochrane Review)

2011 Vitiligo in adults and children (BMJ Clinical Evidence)

 

Oral levamisole

2015 Interventions for vitiligo (Cochrane Review)

2011 Vitiligo in adults and children (BMJ Clinical Evidence)

 

Oral ginkgo biloba
 

Oral antioxidants—vitamin E, Polypodium, L-phenylalanine, vitamin B12, folic acid & zinc sulphate
 

Azathioprine
 

Minocycline
2015 Interventions for vitiligo (Cochrane Review)
 

 

JAK/STAT inhibitors
 

Note: Other oral treatments used in combination therapies are included under "Phototherapy"


Phototherapy (including combination therapies)

Phototherapy - sunlight
 

Phototherapy - broadband UVB
 

Phototherapy - narrowband UVB

2020 Current art of combination therapy with autologous platelet-rich plasma for stable vitiligo: A meta-analysis

2020 The effects of tacrolimus plus phototherapy in the treatment of vitiligo: a meta-analysis

2020 Efficacy of combination therapy of narrowband-ultraviolet B phototherapy or excimer laser with topical tacrolimus for vitiligo: An updated systematic review and meta-analysis

2020 The efficacy of fractional carbon dioxide laser combined with narrow-band ultraviolet B phototherapy for non-segmental vitiligo: a systematic review and meta-analysis

2020 Repigmentation in vitiligo using Janus kinase (JAK) inhibitors with phototherapy: systematic review and meta-analysis

2018 Antioxidant supplements in combination with phototherapy for vitiligo: A systematic review and meta-analysis of randomized controlled trials

2018 The role of phototherapy in the surgical treatment of vitiligo: a systematic review

2017 Phototherapy for vitiligo: A systematic review and meta-analysis

2016 Effect of narrow band ultraviolet B phototherapy as monotherapy or combination therapy for vitiligo: a meta-analysis

2016 Interventions for vitiligo (summary of Cochrane Review)

2016 Oral Chinese herbal medicine in combination with phototherapy for vitiligo: A systematic review and meta-analysis of randomized controlled trials

2016 Evidence-based management of vitiligo: summary of a Cochrane systematic review

2016 Exploring the gaps in the evidence-based application of narrowband UVB for the treatment of vitiligo

2016 Efficacy and safety of 308-nm monochromatic excimer lamp versus other phototherapy devices for vitiligo: a systematic review with meta-analysis

2016 Targeted phototherapy

2015 Interventions for vitiligo (Cochrane Review)

2015 Treatment of vitiligo with NB-UVB: A systematic review

2012 Evidence-based, non-surgical treatments for vitiligo: a review

2011 Vitiligo in adults and children (BMJ Clinical Evidence)

2008 Therapeutic interventions for vitiligo

1998 Nonsurgical repigmentation therapies in vitiligo. Meta-analysis of the literature

 

Phototherapy - monochromatic excimer lamp (UVB)
 

Phototherapy - lasers
 

Phototherapy – UVA
 

Phototherapy – topical PUVA (psoralen plus UVA)
 

Phototherapy – oral PUVA (psoralen plus UVA) & PUVAsol
 

Phototherapy - topical khellin plus UVA
 

Surgical interventions

Cultured cellular transplantation
 

Non-cultured cellular transplantation
 

Punch grafts/mini-grafts
 

Blister grafts
 

Split-thickness grafts
 

Needling
 

Laser ablation — Er-YAG & fractional CO2 lasers
 

Other treatments

Psychological & educational
 

Chinese herbal medicine
 

Complementary & alternative therapies and dietary
 

 

Centre of Evidence Based Dermatology

The University of Nottingham
King's Meadow Campus
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Nottingham, NG7 2NR


telephone: +44 (0) 115 823 1048
email:cebd@nottingham.ac.uk