Centre of Metabolism, Ageing, and Physiology

Image of Mathew Piasecki

Mathew Piasecki

Assistant Professor - Clinical, Metabolic and Molecular Physiology, Faculty of Medicine & Health Sciences



My research focus is the age-related remodelling of skeletal muscle motor units; the reduction in motor unit number and corresponding expansion of motor unit size/innervation ratio. Occurring via repeated cycles of fibre denervation and reinnervation, it is evident this compensatory mechanism of axonal sprouting is not always successful and may be influenced by activity levels, thus highlighting the plasticity of the peripheral neuromuscular system. To date these investigations have involved intramuscular EMG at the single motor unit/muscle fibre level combined with in/voluntary contractions, with current work also involving alterations in gene expression and immunohistochemistry data. Among the aims here is to establish imaging biomarkers of age-related neuromuscular dysfunction and associate them with clinically relevant functional outcomes.

Teaching Summary

I teach on a variety of topics on both the Graduate Entry Medical Course and the BSc in Medical Physiology and Therapeutics.

Recent Publications

  • ELLWOOD, REBECCA A, SLADE, LUKE, LEWIS, JONATHAN, TORREGROSSA, ROBERTA, SUDEVAN, SURABHI, PIASECKI, MATHEW, WHITEMAN, MATTHEW, ETHERIDGE, TIMOTHY and SZEWCZYK, NATHANIEL J, 2022. Sulfur amino acid supplementation displays therapeutic potential in a C. elegans model of Duchenne muscular dystrophy. Communications biology. 5(1), 1255
  • HARDY, EDWARD J., HATT, JACOB, DOLEMAN, BRETT, SMART, THOMAS F., PIASECKI, MATTHEW, LUND, JONATHAN N. and PHILLIPS, BETHAN E., 2022. Post-operative electrical muscle stimulation attenuates loss of muscle mass and function following major abdominal surgery in older adults: a split body randomised control trial AGE AND AGEING. 51(10),
  • GUO, Y., JONES, E. J., INNS, T. B., PHILLIPS, B. E., ATHERTON, P. J. and PIASECKI, M., 2022. Reduced amplitude of persistent inward currents in the aged human vastus lateralis ACTA PHYSIOLOGICA. 236, 357-359
  • JONES, E. J., GUO, Y., ATHERTON, P., PHILLIPS, B. E. and PIASECKI, M., 2022. Motor unit firing rate variability and microvascular blood flow as mediators of neuromuscular control. ACTA PHYSIOLOGICA. 236, 142-143

Clinical, Metabolic and Molecular Physiology

Division of Medical Sciences and Graduate Entry Medicine
The University of Nottingham
Royal Derby Hospital
Uttoxeter Road, Derby, DE22 3DT

telephone: +44 (0)1332 724622