Clinical, Metabolic and Molecular Physiology
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Mathew Piasecki

Assistant Professor - Clinical, Metabolic and Molecular Physiology, Faculty of Medicine & Health Sciences

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Biography

My research focus is the age-related remodelling of skeletal muscle motor units; the reduction in motor unit number and corresponding expansion of motor unit size/innervation ratio. Occurring via repeated cycles of fibre denervation and reinnervation, it is evident this compensatory mechanism of axonal sprouting is not always successful and may be influenced by activity levels, thus highlighting the plasticity of the peripheral neuromuscular system. To date these investigations have involved intramuscular EMG at the single motor unit/muscle fibre level combined with in/voluntary contractions, with current work also involving alterations in gene expression, immunohistochemistry and c.elegans as an experimental model. Among the aims here is to establish imaging biomarkers of age-related neuromuscular dysfunction and associate them with clinically relevant functional outcomes.

Teaching Summary

I teach on a variety of topics on both the Graduate Entry Medical Course and the BSc in Medical Physiology and Therapeutics.

Recent Publications

Clinical, Metabolic and Molecular Physiology

Division of Medical Sciences and Graduate Entry Medicine
The University of Nottingham
Royal Derby Hospital
Uttoxeter Road, Derby, DE22 3DT


telephone: +44 (0)1332 724622
email:gem@nottingham.ac.uk