Chronic liver disease presents a major global public health challenge. Stratification of asymptomatic, at-risk patients in primary care using non-invasive methods such as genotyping has the potential to address this by identifying those likely to progress. We evaluated variant alleles at 3 loci associated with non-alcoholic and alcoholic liver disease (NAFLD and ALD) as genetic determinants of liver fibrosis in 536 patients with disease risk factors in an observational cross-sectional study. Levels of serum pro-collagen III (PIIINP), an established fibrosis marker, and genotypes PNPLA3 rs738409, GCKR rs1260326 and TM6SF2 rs58542926 were determined and the potential for predicting liver fibrosis in at-risk individuals identified assessed.
Speaker: Dr Jane Grove
Sandwiches and refreshments provided.
The University of Nottingham E Floor, West Block, Queen's Medical Centre Nottingham, NG7 2UH
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