GI and Liver Diseases Medical and Surgical Research
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Tanya Monaghan

Clinical Associate Professor, Anne McLaren Fellow and Honorary Consultant in Gastroenterology, Faculty of Medicine & Health Sciences

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Biography

I was appointed as the first NIHR Academic Clinical Fellow in Gastroenterology in 2006. During my clinical training, I was subsequently awarded a three-year Wellcome Trust Clinical Training Fellowship in 2009 to study the host immune response to C. difficile toxins A and B, the principal virulence factors involved in disease pathogenesis, and was awarded my PhD in 2013. I then commenced an NIHR Academic Clinical Lectureship in Gastroenterology in the Nottingham Digestive Diseases Biomedical Research Unit. I was awarded an Academy of Medical Sciences Starter Grant for Clinical Lecturers to study novel antimicrobial treatments for C. difficile infection, utilising a human in vitro gut model of CDI developed by Professor Mark Wilcox, University of Leeds. In collaboration with the Immunology Department at UoN and with the help of a subsequent Hermes Fellowship, I have also adapted a protein microarray platform to investigate antigen-specific antibody responses in the circulation of patients with CDI. This assay is also being used a prediction tool and has recently moved into PCT.

I have established collaborations with Dr Nick Hannan, University of Nottingham and CHAIN Biotechnology to determine the utility of a human stem-cell derived intestinal organoid culture model in modelling Crohn's disease and studying C. difficile pathogenesis. We are exploring ways to use this model to develop and test new therapies for C. difficile infection and inflammatory bowel disease. I am also collaborating with Dr Nick Markham, Vanderbilt University in studying C. difficile infection-associated epigenetic alterations using murine models of infection. I work closely with Dr Dina Kao at the University of Alberta and Dr Christos Polytarchou at Nottingham Trent University and lately, Kelsey Huus and Brett Finlay, University of British Columbia, to study molecular mechanisms of action of faecal microbiota transplantation therapy for C. difficile infection.

In 2017, I was awarded an Anne McLaren Fellowship to study Clostridium difficile infection in urbanised and tribal communities in Central India in collaboration with the Central India Institutes of Medical Sciences (CIIMS), Mahatma Gandhi Tribal Hospital, Melghat Tiger Reserve and the C. difficile Ribotyping Network, Leeds. Since commencing this project, we have expanded our research programme to also concentrate on more broadly studying the aetiology of infectious diarrhoea using multiplex PCR and anaerobic culture programmes. These studies have been funded by two University of Nottingham Research Priority Area grants. We have recently been awarded a GCRF Network Grant to develop an Indo-UK interdisciplinary networking partnership for tackling infectious diarrhoea in Central India in collaboration with researchers in the School's of Geography, Health Sciences, Veterinary Medicine and Science in Nottingham, and externally with the London School of Hygiene and Tropical Medicine and multiple institutions in India including CIIMS, the Central Council of India Medicine, New Delhi, Government Medical College, Nagpur Veterinary Collaege, National Environmental Engineering Research Institute, Nagpur, University of Hyderabad, Maharashtra Association of Anthropological Science, Pune and Kasturba Medical College and Hospital Manipal, Kamataka. I collaborate with Tim Sloan and Adam Blanchard, both University of Nottingham academics and APC Microbiome Cork (Stephen Stockdale, Lorraine Draper and Colin Hill), as well as The Chinese University of Hong Kong (Siew Ng) on faecal metagenome studies.

Allied to my research studies in India, I am working closely with Weng Chan in the School of Pharmacy in Nottingham on a recently funded MRC DPFS grant to develop LY256, a novel and potent antibiotic for treating C. difficile infection. Finally, I have started collaborating with Professor Nicola Pitchford in the School of Psychology on a University of Nottingham GCRF Interdisciplinary Award assessing the impact of socio-biological risk factors on infant development in Malawi.

Expertise Summary

C. difficile infection - adaptive immune responses to C. difficile toxins A and B in varied patient groups (University of Nottingham)

  • Developmental ELISA and ELISPOT assays
  • Protein microarray assays
  • Antigen-specific flow cytometry
  • In vitro gut models of C. difficile infection

Novel anti-C. difficile antimicrobials (University of Nottingham)

  • LY256: a novel and potent antibiotic for treating C. difficile infection

Mechanisms of action of faecal microbiota transplantation (University of Nottingham, Nottingham Trent University, University of Alberta, University of British Columbia)

  • Specific focus on immunometabolic and epigenetic factors

Faecal metagenomics (University of Nottingham, Central India Institute of Medical Sciences, The Chinese University of Hong Kong, APC Microbiome)

  • Metagenomics reveals impact of geography, antibiotics and acute diarrhoeal disease on the gut microbiome of Central Indian populations
  • GAME-COSMIC Study
  • Deciphering gut microbiome-glycomic-immune system interactions in health and disease: a meta-omics study

Medical Education publishing:

  • Oxford Handbook of Clinical Examination and Practical Skills. Thomas J, Monaghan T. Pub: Oxford University Press, Oxford. June 2007.
  • 2 ed. published July 2014.
  • "Highly commended" at BMA Medical Book Awards 2015
  • Oxford Handbooks Clinical Tutor Study Cards: Medicine. Monaghan T, Thomas J. Pub: Oxford University Press, Oxford. September 2011
  • Oxford Handbooks Clinical Study Cards: Surgery. Monaghan T, Thomas J, Humes D. Pub: Oxford University Press, Oxford. September 2011
  • Oxford Handbooks Clinical Study Cards: Practical Procedures. Thomas J, Monaghan T, Thompson A. Pub: Oxford University Press, Oxford. September 2011.

Research Summary

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Recent Publications

Current Research

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Nottingham Digestive Diseases Centre

The University of Nottingham
E Floor, West Block, Queen's Medical Centre
Nottingham, NG7 2UH


telephone: +44 (0) 115 82 31090
email:nddcbru@nottingham.ac.uk