Rachael Tarlinton

Contact

• workSchool of Veterinary Medicine and Science
  Sutton Bonington Campus
  Sutton Bonington
  Leicestershire
  LE12 5RD
  UK
• work0115 951 6273
• rachael.tarlinton@nottingham.ac.uk

Biography

Rachael graduated with a BVSc from Sydney University in 1999 and worked in mixed practice in Australia and the UK. She then did PhD on retroviruses of koalas at the University of Queensland. She spent time after this working as a postdoctoral researcher for the Queensland Department of Primary Industries participating in vaccine trials testing oral vaccination strategies for ruminants and at Georg August Universitaet Goettingen in Germany, examining the interactions between human coronaviruses, including SARs, and human plasmacytic dendritic cells. She then joined the School of Veterinary Medicine and Science in 2007 where she teaches undergraduate and clinical phase veterinary medicine students and runs a research program in animal infectious diseases.

Expertise Summary

Rachael is an Associate Professor of Veterinary Cellular Microbiology and a European Diplomate in Veterinary Microbiology. Her research expertise is in animal virology, particularly retroviruses but covers a broad range of virology and genetics methods in domestic and exotic species. She is currently serving as the schools biosafety officer responsible for risk assessment of biological and genetic modification work. She is available for consultancy work on biosafety and biosecurity risks. She also teaches clinical skills and internal medicine into the undergraduate veterinary curriculum.

Teaching Summary

Due to my clinical background I teach across a range of courses at SVMS from 1st through to 4th year. I do much of the introductory surgery practical classes and am responsible for tracking the… read more

Research Summary

My research is split into two broad themes, the first on endogenous retroviruses. These viruses are the remnants of past infections that have become incorporated in their hosts genome (about 10% of… read more

Selected Publications

• CHAPPELL, J.G., TSOLERIDIS, T., ONIANWA, O., DRAKE, G., ASHPOLE, I., DOBBS, P., EDEMA, W., KUMI-ANSAH, F., BENNETT, M., TARLINTON, R.E., BALL, J.K. and MCCLURE, C.P., 2020. Retrieval of the Complete Coding Sequence of the UK-Endemic Tatenale Orthohantavirus Reveals Extensive Strain Variation and Supports Its Classification as a Novel Species Viruses. 12, 454
• TSOLERIDIS, T, CHAPPELL, J, ONIANWA, O, MARSTON, D A, FOOKS, A R, MONCHATRE-LEROY, E, UMHANG, G, MULLER, M M, DREXLER, J F, DROSTEN, C, TARLINTON, R E, MCCLURE, C P, HOLMES, E C and BALL, J K, 2019. Shared common ancestry of alphacoronaviruses in globally distributed rodents Viruses. 11(2), 125
• MORANDI, E., TANASESCU, R., TARLINTON, R.E., CONSTANTIN-TEODOSIU, D. and GRAN, B., 2019. Do Antiretroviral Drugs Protect From Multiple Sclerosis By Inhibiting Expression Of MS-Associated Retrovirus? Frontiers in Immunology. 9, 3092
• STOKES JE, TARLINTON RE, LOVATT F, BAYLIS M, CARSON A and DUNCAN JS, 2018. Survey to determine the farm-level impact of Schmallenberg virus during the 2016-2017 United Kingdom lambing season. The Veterinary record. 183, 690

• View all publications

Due to my clinical background I teach across a range of courses at SVMS from 1st through to 4th year. I do much of the introductory surgery practical classes and am responsible for tracking the preventative medicine curriculum across the course, this covers everything from antimicrobial prescribing to nutrition. I also manage the second year biosciences course "Principals of Animal Health and Disease" open to science students across the university.

Current Research

My research is split into two broad themes, the first on endogenous retroviruses. These viruses are the remnants of past infections that have become incorporated in their hosts genome (about 10% of the human genome is made up of segments of retrovirus). I am particularly interested in the process by which retroviruses become integrated into their host's normal cellular functions. I have current projects on Koala retrovirus (KoRV), Feline leukaemia virus and the role of human endogenous retroviruses in autoimmune diseases such as Multiple Sclerosis. Recent work has included retroviruses in dogs, horses, primates, chickens and squirrels. I also work on infectious retroviruses with current projects on the impacts of Maedi Visna in sheep breeding.

I also have research interests in emerging viral diseases and viral diseases in domestic animals. My current projects include SARS-CoV-2 in wildlife (UK and India), Schmallenberg virus impacts on ruminant reproduction, tick borne diseases of Nigerian dogs, European hantaviruses and novel rodent viruses and Elephant Endotheliotropic Herpesvirus 1 (the cause of a fatal haemorrhagic syndrome in juvenile elephants). Past work has included rabies and tick borne diseases of Indian street dogs, SARs-CoV-1 immunology and oral vaccination systems for ruminants.

For details of this and other infectious diseases research in SVMS please see the Animal Infection and Immunity web page

• JONES, S., MCKAY, H., EDEN, L., BOLLARD, N., DUNHAM, S., DAVIES, P. and TARLINTON, R., 2022. Clearance of Maedi Visna Infection in a longitudiional study of naturally infected rams is associated with homozygosity for the TMEM154 resistance allele Journal of Medical Microbiology. (In Press.)
• SHAKIROVA, VENERA, KHAERTYNOVA, ILSEYAR, MARKELOVA, MARIA, TARLINTON, RACHAEL, BEHNKE, JERZY, MARTYNOVA, EKATERINA, GARANINA, EKATERINA, RIZVANOV, ALBERT and KHAIBOULLINA, SVETLANA, 2022. Serum Cytokine Alterations Associated with Age of Patients with Nephropathia Epidemica. BioMed research international. 2022, 4685288
• TARLINTON R E, LEGIONE A R, SARKER N, FABIJAN J, MEERS J, MCMICHAEL L, SIMMONS G, OWEN H, SEDDON J M, DICK G, RYDER J S, HEMMATZEDAH F, TROTT D J, SPEIGHT N, HOLMES N, LOOSE M and EMES R D E, 2022. Differential and defective transcription of Koala Retrovirus indicate complexity of host and virus evolution Journal of General Virology. (In Press.)
• CURWEN A, JONES S, STAYLEY C, EDEN L, MCKAY H, DAVIES P, LOVATT F, DUNHAM S and TARLINTON R, 2022. Lack of Schmallenberg Virus Detection in Ram Semen Vet Record open. In press
• TARLINTON, R.E., FABIJAN, J., HEMMATZADEH, F., MEERS, J., OWEN, H., SARKER, N., SEDDON, J., SIMMONS, G., SPEIGHT, N., TROTT, D., WOOLFORD, L. and EMES, R.D.E., 2021. Transcriptomic and genomic variants between koala populations reveals underlying genetic components to disorders in a bottlenecked population Conservation Genetics.
• MCEWAN, G.K., ALQUEZAR-PLANAS, D.E., DAYARAM, A., GILLET, A., TARLINTON, R., MONGAN, N., CHAPPELL, K., HENNING, J., TAN, M., TIMMS, P., YOUNG, P., ROCA, A.L. and GREENWOOD, A., 2021. Retroviral integrations contribute to elevated host cancer rates during germline invasion Nature communications. 1316
• TSOLERIDIS T, CHAPPELL JG, MONCHATRE-LEROY E, UMHANG G, SHI M, BENNETT M, TARLINTON RE, MCCLURE CP, HOLMES EC and BALL JK, 2020. Discovery and Prevalence of Divergent RNA Viruses in European Field Voles and Rabbits. Viruses. 12(1),
• SARKER N, FABIJAN J, OWEN H, SEDDON J, SIMMONS G, SPEIGHT N, KALER J, WOOLFORD L, EMES RD, HEMMATZADEH F, TROTT DJ, MEERS J and TARLINTON RE, 2020. Koala retrovirus viral load and disease burden in distinct northern and southern koala populations. Scientific reports. 10(1), 263
• SARKER, N., TARLINTON, R., OWEN, H., EMES, R.D., SEDDON, J., SIMMONS, G. and MEERS, J., 2020. Novel insights into viral infection and oncogenesis from Koala Retrovirus(KoRV) infection of HEK293T cells Gene. (In Press.)
• FABIJAN, J., SARKER, N., SPEIGHT, N., OWEN, H., MEERS, J., SIMMONS, G., SEDDON, J., EMES, R.D.E., TARLINTON, R., HEMMATZADEH, F., WOOLFORD, L. and TROTT, D., 2020. Pathological Findings in Retrovirus-positive Koalas (Phascolarctos cinereus) From Northern and Southern Australia Journal of Comparative Pathology. 176, 50-66
• CHAPPELL, J.G., TSOLERIDIS, T., ONIANWA, O., DRAKE, G., ASHPOLE, I., DOBBS, P., EDEMA, W., KUMI-ANSAH, F., BENNETT, M., TARLINTON, R.E., BALL, J.K. and MCCLURE, C.P., 2020. Retrieval of the Complete Coding Sequence of the UK-Endemic Tatenale Orthohantavirus Reveals Extensive Strain Variation and Supports Its Classification as a Novel Species Viruses. 12, 454
• TARLINTON, R.E., MARTYNOVA, E., RIZVANOV, A., KHAIBOULLINA, S. and VERMA, S., 2020. Role of Viruses in the Pathogenesis ofMultiple Sclerosis Viruses. 12, 643
• TARLINTON, R.E., KHAIBOULLIN, T., GRANATOV, E., MARTYNOVA, E., RIZVANOV, A. and KHAIBOULLINA, S., 2019. The Interaction between Viral and Environmental Risk Factors in the Pathogenesis of Multiple Sclerosis International Journal of Molecular Sciences.
• MORANDI, E., TANASESCU, R., TARLINTON, R.E., CONSTANTIN-TEODOSIU, D. and GRAN, B., 2019. Do Antiretroviral Drugs Protect From Multiple Sclerosis By Inhibiting Expression Of MS-Associated Retrovirus? Frontiers in Immunology. 9, 3092
• TSOLERIDIS, T, CHAPPELL, J, ONIANWA, O, MARSTON, D A, FOOKS, A R, MONCHATRE-LEROY, E, UMHANG, G, MULLER, M M, DREXLER, J F, DROSTEN, C, TARLINTON, R E, MCCLURE, C P, HOLMES, E C and BALL, J K, 2019. Shared common ancestry of alphacoronaviruses in globally distributed rodents Viruses. 11(2), 125
• JONES, S., EDEN, L., MCKAY, H., BOLLARD, N., DUNHAM, S., DAVIES, P. and TARLINTON, R.E., 2019. Schmallenberg virus neutralising antibody responses in sheep BMC veterinary research. 15, 426
• GARANINA, E., MARTYNOVA, E.,, DAVIDYUK, Y., KABWE, E., IVANOV, K., TITOVA, A., MARKELOVA, M., ZHURAVLEVA, M., CHEREPNEV, G., SHAKIROVA, V.G., KHAERTYNOVA, I., TARLINTON, R., RIZVANOV, A.,, KHAIBOULLINA, S., and MORZUNOV, S., 2019. Cytokine Storm Combined With Humoral Immune Response Defect In Fatal Hemorrhragic Fever With Renal Syndrome Case, Tatarstan, Russia Viruses. 11, 601
• SARKER, N., FABIJAN, J., SEDDON, J., TARLINTON, R., OWEN, H., SIMMONS, G., THIA, J., BLANCHARD, A.M., SPEIGHT, N., KALER, J., EMES, R.D.E., WOOLFORD, L., HEMMATZADEH, F., TROTT, D. and MEERS, J., 2019. Genetic diversity of Koala retrovirus (KoRV) env gene subtypes: Insights into northern and southern koala populations Journal of General Virology.
• KLETENKOV, K., MARTYNOVA, E., DAVIDYUK, Y., KABWE, E., SHAMSUTDINOV, A., GARANINA, E., SHAKIROVA, V.G., KHAERTYNOVA, I., ANOHKIN, V., TARLINTON, R., RIZVANOV, A., KHAIBOULLINA, S. and MORZUNOV, S., 2019. Δccr5 Genotype Is Associated with Mild Form of Nephropathia Epidemica Viruses. 11, 675
• TARLINTON, R.E., WANG, B., MORANDI, E., GRAN, B., KHAIBOULLIN, T., MARTYNOVA, E.,, RIZVANOV, A., and KHAIBOULLINA, S., 2019. Differential Expression of HERV-W in Peripheral blood in Multiple Sclerosis and Healthy Patients in Two Different Ethnic Groups Frontiers in Immunology. (In Press.)
• SARKER, N., FABIJAN, J., EMES, R.D, HEMMATZADEH, F., MEERS, J., MORETON, J., OWEN, H., SEDDON, J.M., SIMMONS, G., SPEIGHT, N., TROTT, D., WOOLFORD L. and TARLINTON, R.E.,, 2018. Identification of stable reference genes for quantitative PCR in koalas Scientific Reports. 8, 3364
• STOKES JE, TARLINTON RE, LOVATT F, BAYLIS M, CARSON A and DUNCAN JS, 2018. Survey to determine the farm-level impact of Schmallenberg virus during the 2016-2017 United Kingdom lambing season. The Veterinary record. 183, 690
• BROWN, K and TARLINTON, R, 2017. Is gibbon ape leukaemia virus still a threat? Mammal Review. 47, 53-61
• MORANDI E, TANASESCU R, TARLINTON RE, CONSTANTINESCU CS, ZHANG W, TENCH C and GRAN B, 2017. The association between human endogenous retroviruses and multiple sclerosis: A systematic review and meta-analysis. PloS one. 12(2), e0172415
• MORANDI E, TARLINTON RE, TANASESCU R and GRAN B, 2017. Human endogenous retroviruses and multiple sclerosis: Causation, association, or after-effect? Multiple sclerosis (Houndmills, Basingstoke, England). 1352458517704711
• STAVROU, A, DALY, J, MADDISON, B, GOUGH, K and TARLINTON, R, 2017. How is Europe positioned for a re-emergence of Schmallenberg virus? The Veterinary Journal. 230, 45-51
• T. TSOLERIDIS, O. ONAINWA, E. HORNCASTLE, E. DAYMAN, M. ZHU, T. DANJITTRONG, M.WACHTL, J. BEHNKE, S. CHAPMAN, V. STRONG, P. DOBBS, J. BALL, R. TARLINTON and C.P. MCCLURE, 2016. Discovery of Novel Alphacoronaviruses in European Rodents and Shrews Viruses. 8, 84
• R. TARLINTON, L.ALDER, J.MORETON, G.MABONI, R.EMES and S.TOTEMEYER, 2016. RNA expression of TLR10 in normal equine tissues BMC research notes. 353
• T.T.APAA, J.M.DALY and R.E.TARLINTON, 2016. Canine parvovirus (CPV-2) variants circulating in Nigerian dogs Vet Record Open. 3, e000198
• DALY, JM, KING, B, TARLINTON, R, GOUGH, KC, MADDISON, BC and BLOWEY, R, 2015. Comparison of Schmallenberg virus antibody levels detected in milk and serum from individual cows BMC Vet Res. 11, 56
• KING BJ, O'SHEA BROWN T, TARLINTON R and DALY JM, 2015. Seroprevalence of Schmallenberg virus in the United Kingdom and Republic of Ireland: 2011-2013 Veterinary Microbiology. 180(1-2), 36-40
• LAURA BENNETT, STEPHEN DUNHAM, LISA YON, SARAH CHAPMAN, MEGAN KENAGHAN, LAURA PURDIE and RACHAEL TARLINTON, 2015. Longitudinal study of Asian elephants, Elephas maximus, indicates intermittent shedding of elephant endotheliotropic herpesvirus 1 during pregnancy Veterinary Record Open.
• MORANDI E and TARLINTON R E, 2015. Multiple Sclerosis between Genetics and Infections: Human Endogenous Retroviruses in Monocytes and Macrophages. Fronteirs in Immunology. 6(647),
• JOANNA MORETON, SUNII MALLA, A.AZIZ ABOOBAKER, RACHAEL TARLINTON and RICHARD D. EMES, 2014. Characterisation of the horse transcriptome from immunologically active tissues PeerJ. 2:e382
• BROWN K, EMES RD and TARLINTON RE, 2014. Multiple groups of endogenous epsilon-like endogenous retroviruses conserved across primates. Journal of virology. 88, 12464-71
• TARLINTON, R.E., BARFOOT, H.K.R., ALLEN, C.E., BROWN, K., GIFFORD, R.J. and EMES, R.D., 2013. Characterisation of a group of endogenous gammaretroviruses in the canine genome Veterinary Journal. 196(1), 28-33
• TARLINTON R and DALY J, 2013. Testing for Schmallenberg virus. The Veterinary record. 172(7), 190
• KYDD JH, COBB K, DAVIS R, DEAN R, DRINKWATER J, DUNHAM S, FLYNN R, GRAY C, GROGONO-THOMAS R, HAGAN P, JEFFERIES A, JONES M, OGDEN C, PEARSON G, ROBINSON N, RUTLAND C, TARLINTON R, TÖTEMEYER S, WASON J, WHITTINGTON R, WILLIAMS L and MOSSOP L, 2013. Report of the first veterinary student support workshop. The Veterinary record. 173(14), 346
• TARLINTON R, DALY J, DUNHAM S and KYDD JH, 2013. Schmallenberg virus: could wildlife reservoirs threaten domestic livestock? Veterinary journal (London, England : 1997). 198(2), 309-10
• WISE AE and TARLINTON RE, 2012. Seroprevalence Of Vectorborne Diseases In Free-Roaming Dogs In Goa, India. The Veterinary Record. 170(3), 76
• TARLINTON, R., DALY, J., DUNHAM, S. and KYDD, J., 2012. The challenge of Schmallenberg virus emergence in Europe Veterinary Journal. 194(1), 10-18
• BROWN, K., MORETON, J., MALLA, S., ABOOBAKER, A. A., EMES, R.D. and TARLINTON, RACHAEL, E.,, 2012. Characterisation of retroviruses in the horse genome and their transcriptional activity via transcriptome sequencing Virology. 433(1), 55-63
• TARLINTON, RACHAEL E and DUNHAM, STEPHEN P, 2011. Pushing the envelope: Advances in molecular techniques for the detection of novel viruses. Veterinary journal.
• TARLINTON, R.E., TATE, H.F.J., MOHALLAL, E.M.E., DALY, J.M. and BEHNKE, J.M., 2011. Betaherpesvirus sequences in eastern spiny mice and Wagner's dipodils Journal of Wildlife Diseases. 47(4), 958-962
• TARLINTON, RE, YON, L, KLISCH, K, TOTEMEYER, S and GOUGH, KC, 2011. Confidence As A Barrier To The Use Of Problem-Based Learning In Veterinary Undergraduate Students Journal Of Veterinary Medical Education. 38(3), 305-310
• TARLINTON, R., MEERS, J. and YOUNG, P, 2008. Endogenous retrovirus. Cellular and Molecular Life Sciences. 65(21), 3413-3421
• TARLINTON, RE, MEERS, J and YOUNG, PR, 2006. Retroviral Invasion Of The Koala Genome Nature. 442(7098), 79-81
• TARLINTON, R, MEERS, J, HANGER, J and YOUNG, P, 2005. Real-Time Reverse Transcriptase Pcr For The Endogenous Koala Retrovirus Reveals An Association Between Plasma Viral Load And Neoplastic Disease In Koalas Journal Of General Virology. 86, 783-787