Stem Cell Biology

Re-advertisement: BBSRC-DTP iCase Studentship - Understanding the role of microbial metabolites in the initiation and progression of Crohn's Disease


Applications are invited to join the University of Nottingham BBSRC iCASE Studentship to undertake an innovative four-year PhD training programme to work on a specific project:

Understanding the role of microbial metabolites in the initiation and progression of Crohn’s Disease

Crohn’s disease (CD) is a debilitating disease where chronic inflammation leads to intestinal perforation that requires surgical removal in up to 50% of cases. Recent evidence suggests that changes in intestinal microbiome may be responsible for the initiation and progression of the disease. Bacterial metabolites have been shown to influence intestinal inflammation making them interesting candidates for the management of CD. This project will bring together two advanced technologies developed by Hannan (in-vitro IBD models) and CHAIN Biotechnology (engineering of bacteria to deliver bio-therapeutic products). During the project we will create an in-vitro model of CD using primary tissue biopsy from patients with CD. In collaboration with CHAIN Biotechnology we will then investigate how bacterial metabolites influence gene expression in CD and healthy intestinal epithelium and determine the feasibility of using engineered bacteria as a microbial vehicle for delivering bioactives to the gut to treat CD. 

Contact: Dr Nicholas Hannan , School of Medicine

How to apply

Applications should include a fully completed application form, CV (no more than 2 sides of A4), a transcript of module marks and two references.  (PLEASE ENSURE THAT YOU CONTACT YOUR REFEREES AND LET THEM KNOW THAT WE NEED THEIR REFERENCES BY THE DEADLINE)

Application forms and CVs should be named in the following format: SURNAME-initial-[BBSRC iCASE]-application.doc (.docx or .pdf) and SURNAME-initial-[BBSRC iCASE]-cv.doc (.docx or.pdf) e.g. SMITH-A-[BBSRC iCASE]-application.doc 

Applications should be sent via email with the subject line ‘BBSRC iCASE Application’ to Dr Nicholas Hannan by the deadline: Friday 30 June 2017. 

References should be sent directly from the referees to ( by the deadline:  30 June 2017.  Further details are on the reference form.  

Enquiries should be sent to Dr Nicholas Hannan.

Please quote ref: BBSRC iCASE Studentship Application

Interviews will be conducted in the week commencing 17 July 2017

Please note that scholarships will be awarded on the following basis: Home students only: fees and stipend.

Application form

Referee form

More about the Biotechnology and Biological Sciences Doctoral Training Programme











Posted on Thursday 23rd February 2017

Wolfson Centre for Stem cells, Tissue Engineering and Modelling (STEM)

The University of Nottingham
Centre for Biomolecular Sciences
University Park
Nottingham NG7 2RD

telephone: +44 (0) 115 823 1231