2014 Publications
Highlights | 2016 | 2015 | 2014 | 2013 | 2012 | Archived
Synthesis of macrolactam analogues of radicicol and their binding to heat shock protein Hsp90. B. L. Dutton, R. R. A. Kitson, S. Parry-Morris, S. M. Roe, C. Prodromou and C. J. Moody. Org. Biomol. Chem., 2014, 12, 1328-1340.
Benzofuranquinones as inhibitors of indoleamine 2,3-dioxygenase (IDO). Synthesis and biological evaluation. C. Carvalho, D. Siegel, M. Inman, R. Xiong, D. Ross and C. J. Moody. Org. Biomol. Chem., 2014, 12, 2663-2674.
19-Substituted benzoquinone ansamycin heat shock protein-90 inhibitors: Biological activity and decreased off-target toxicity. C.-H. Chang, D. A. Drechsel, R. R. A. Kitson, D. Siegel, Q. You, D. S. Backos, C. Ju, C. J. Moody and D. Ross. Mol. Pharm., 2014, 85, 849-857.
Antitumour indolequinones: synthesis and activity against human pancreatic cancer cells. M. Inman, A. Visconti, C. Yan, D. Siegel, D. Ross and C. J. Moody. Org. Biomol. Chem., 2014, 12, 4848-4861.
Surgical delivery of drug-releasing poly(lactic-co-glycolic acid) / poly(ethylene glycol) paste with in vivo effects against glioblastoma. Smith SJ, Rahman CV, Clarke PA, Ritchie AA, Gould TW, Ward JH, Shakesheff KM, Grundy RG, Rahman R. Annals of Royal College of Surgeons England 96 (2014): 495-501.
RHPS4 G-quadruplex ligand induces telomere length independent anti-proliferative effects in childhood brain tumor cells with associated telomerase inhibition. Lagah S, Tan I-L, Radhakrishnan P, Hirst RA, Ward JH, O’Callaghan C, Smith SJ, Stevens MFG, Grundy RG, Rahman R. PLoS One 9(1) (2014): e86187.
Low calpain-9 is associated with adverse disease-specific survival following endocrine therapy in breast cancer. Davis J, Martin SG, Patel PM, Green AR, Rakha EA, Ellis IO, Storr SJ. BMC Cancer. 2014 Dec 23;14:995.
Involvement of metformin and AMPK in the radioresponse and prognosis of luminal versus basal-like breast cancer treated with radiotherapy. Zhang Y, Storr SJ, Johnson K, Green AR, Rakha EA, Ellis IO, Morgan DA, Martin SG. Oncotarget. 2014 Dec 30;5(24):12936-49.
Prognostic significance of lymphatic invasion in lymph node-positive breast carcinoma: findings from a large case series with long-term follow-up using immunohistochemical endothelial marker. Mohammed RA, Menon S, Martin SG, Green AR, Paish EC, Ellis IO. Mod Pathol. 2014 Dec;27(12):1568-77.
Redox proteins and radiotherapy. Zhang Y, Martin SG. Clin Oncol (R Coll Radiol). 2014 May;26(5):289-300.
Chemically diverse polymer microarrays and high throughput surface characterisation: a method for discovery of materials for stem cell culture. Celiz AD, Smith JGW, Patel AK, Langer R, Anderson DG, Barrett DA, Young LE, Davies MC, Denning C and Alexander MR. Biomaterials Science (2014) 2, 1604-1611 DOI: 10.1039/c4bm00054d.
Multiplexing Spheroid Volume, Resazurin and Acid Phosphatase Viability Assays for High-Throughput Screening of Tumour Spheroids and Stem Cell Neurospheres. Ivanov DP, Parker TL, Walker DA, Alexander C, Ashford MB, Gellert PR and Garnett MC. PLOS One (2014) 9, 3103817 DOI: 10.1371.journal.pone.0103817.
Treatment decisions and survival for people with small cell lung cancer. Powell H, Tata L, David R Baldwin DR, Potter V, Stanley R, Khakwani A and Hubbard RB. Brit J Cancer 2014; Feb 18;110(4):908-15.
The UK Lung Screen (UKLS): demographic profile of first 88,897 approaches provides recommendations for population screening. McRonald F, Yadegarfar G, Baldwin DR et al. Cancer Prevention Research. 2014 Mar;7(3):362-71. doi: 10.1158/1940-6207.
Small-cell lung cancer in England: Trends in survival and chemotherapy using the National Lung Cancer Audit. Khakwani A, Rich AL, Tata LJ, Powell HA, Stanley RA, Baldwin DR and Hubbard RB. PLOS ONE 2014;9(2)e89426.
The European Initiative for Quality Management in Lung Cancer Care. Blum T, Rich AL, Baldwin DR et al. Eur Resp J 2014; 23 March doi: 10.1183/09031936.00106913.
Appetite Stimulants for people with cystic fibrosis. Chinuck R, Dewar J, Baldwin DR and Hendron E. The Cochrane Collaboration 2014 (Systematic Cochrane review No 700308052811360131).
The impact of the ‘hub and spoke’ model of care for lung cancer and equitable access to surgery. Khakwani A, Rich AL, Powell HA, Tata LJ, Stanley RA, Baldwin DR, Duffy JP and Hubbard RB. Thorax 2014 Thorax thoraxjnl-2014-205841 Published Online First: 2 September 2014 doi:10.1136/thoraxjnl-2014-205841.
What characteristics of primary care and patients are associated with early death in patients with lung cancer in the United Kingdom? O’Dowd E, McKeever T, Baldwin D, Anwar S, Powell H, Gibson J, Iyen-Omofoman B and Hubbard R. Thorax 2014 thoraxjnl-2014-205692 Published Online First: 13 October 2014 doi:10.1136/thoraxjnl-2014-205692.
Brain metastases following radical surgical treatment of non-small cell lung cancer: is preoperative brain imaging important? O’Dowd EL, Kumaran M, Anwar S, Palomo B and Baldwin DR. Lung Cancer 2014 Nov;86(2):185-9. doi: 10.1016/j.lungcan.2014.08.021.
PET-CT for assessing mediastinal lymph node involvement in patients with suspected resectable non-small cell lung cancer. Schmidt-Hansen M, Baldwin DR, Collins E, Zamora J and Abraira V. The Cochrane Collaboration 2014 (Systematic Cochrane Review No 799611011308391659).
Involvement of metformin and AMPK in the radioresponse and prognosis of luminal versus basal-like breast cancer treated with radiotherapy. Zhang Y, Storr SJ, Johnson K, Green AR, Rakha EA, Ellis IO, Morgan DA, Martin SG. Oncotarget. 2014 Dec 30;5(24):12936-49.
Inclusion of KI67 significantly improves performance of the PREDICT prognostication and prediction model for early breast cancer. Wishart GC, Rakha E, Green A, Ellis I, Ali HR, Provenzano E, Blows FM, Caldas C, Pharoah PD. BMC Cancer. 2014 Dec 3;14:908.
Clinicopathological significance of ATM-Chk2 expression in sporadic breast cancers: a comprehensive analysis in large cohorts. Abdel-Fatah TM, Arora A, Alsubhi N, Agarwal D, Moseley PM, Perry C, Doherty R, Chan SY, Green AR, Rakha E, Ball G, Ellis IO, Madhusudan S. Neoplasia. 2014 Nov 20;16(11):982-91.
Anti-nicastrin monoclonal antibodies elicit pleiotropic anti-tumour pharmacological effects in invasive breast cancer cells. Filipovic A, Lombardo Y, Faronato M, Abrahams J, Aboagye E, Nguyen QD, d'Aqua BB, Ridley A, Green A, Rahka E, Ellis I, Recchi C, Przulj N, Sarajlic A, Alattia JR, Fraering P, Deonarain M, Coombes RC. Breast Cancer Res Treat. 2014 Nov;148(2):455-62.
Low calpain-9 is associated with adverse disease-specific survival following endocrine therapy in breast cancer. Davis J, Martin SG, Patel PM, Green AR, Rakha EA, Ellis IO, Storr SJ. BMC Cancer. 2014 Dec 23;14:995.
Insights into low molecular mass organic gelators: a focus on drug delivery and tissue engineering applications. Kathryn J. Skilling, Francesca Citossi, Tracey D. Bradshaw, Marianne Ashford, Barrie Kellam and Maria Marlow. (2014) Soft Matter 10 (2) 237-256.
Novel antitumour indole alkaloid, Jerantinine A, evokes potent G2/M cell cycle arrest targeting microtubules. V J Raja, KH Lim, T S Kam and T D Bradshaw. (2014) Invest New Drugs DOI 10.1007/s 10637-014-0126-1.
Overcoming multiple drug resistance mechanisms in medulloblastoma. Ramadhan T Othman, Ioanna Kimishi, Tracey D Bradshaw, Lisa CD Storer, Andrey Korshunov, Stefan M Pfister, Richard G Grundy, Ian D Kerr and Beth Coyle. (2014) Acta Neuropath Comm 2: 57.
Targeting RNA transcription and translation in ovarian cancer cells with pharmacological inhibitor CDKI-73. Frankie Lam, Abdullahi Y. Abbas, Hao Shao, Theodosia Teo, Julian Adams, Peng Li, Tracey D. Bradshaw, Peter M. Fischer, Elisabeth Walsby, Chris Pepper, Yi Chen, Jian Ding and Shudong Wang. (2014) Oncotarget 5 (17) 7691-7704.
Gelation properties of self-assembling N-acyl modified cytidine derivatives. KJ Skilling, A Ndungu, B Kellam, M Ashford, TD Bradshaw, and M Marlow. J Mat Chem B. 2014, 2, 8412-8417.
Cytotoxicity and apoptotic activities of alpha-, gamma- and delta-tocotrienol isomers on human cancer cells. Su-Wen Lim,Hwei-San Loh, Kang-Nee Ting, Tracey D Bradshaw, Nazariah A Zeenathul. BMC Complementary and Alternative Medicine 2014, 14:469 doi:10.1186/1472-6882-14-469.
Highlights | 2016 | 2015 | 2014 | 2013 | 2012 | Archived