University of Nottingham
  

Events

2nd World Congress on Controversies, Debates & Consensus in Bone, Muscle & Joint Diseases

Date
22/11/2013
Description
We are happy to announce that D-BOARD Consortium have organised a symposium during the 2nd World Congress on Controversies, Debates & Consensus in Bone, Muscle & Joint Diseases.
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Newsletter

 

Publications

Book Chapters
Mobasheri A, Shakibaei M, Biesalski H-K, Henrotin Y. Antioxidants in the Treatment of Osteoarthritis and Bone Mineral Loss. In: Oxidative Stress in Advanced Basic Research and Clinical Practice. Studies on Arthritis and Joint Diseases. Editors: Maria J. Alcaraz, Oreste Gualillo, Olga Sanchez Pernaute. 2013. Springer. ISBN 978-1-4614-6165-4.

Mobasheri A, Henrotin Y. Biomarkers of Oxidative Stress in Joint Diseases. In: Oxidative Stress in Advanced Basic Research and Clinical Practice. Studies on Arthritis and Joint Diseases. Editors: Maria J. Alcaraz, Oreste Gualillo, Olga Sanchez Pernaute. 2013. Springer. ISBN 978-1-4614-6165-4.
 
Articles
Reynard LN, Loughlin J (2013) Insights from human genetic studies into the pathways involved in osteoarthritis. Nature Reviews Rheumatology 9:573-583.

Lewis, R., H. May, A. Mobasheri, and R. Barrett-Jolley, Chondrocyte channel transcriptomics: Do microarray data fit with expression and functional data? Channels, 2013. 7(6) published online 30. August 2013.

Lewis R, Feetham CH, Gentles L, Penny J, Tregilgas L, Tohami W, et al. (2013a). Benzamil sensitive ion channels contribute to volume regulation in canine chondrocytes. Br J Pharmacol 168(7): 1584-1596.

Lewis R, May H, Mobasheri A, Barrett-Jolley R (2013b). Chondrocyte channel transcriptomics: Do microarray data fit with expression and functional data? Channels 7(6): 16-15.

Mobasheri A, Lewis R, Ferreira-Mendes A, Rufino A, Dart C, Barrett-Jolley R (2012). Potassium channels in articular chondrocytes. Channels 6(6): 416-425.

Staunton CA, Lewis R, Barrett-Jolley R (2013). Ion Channels and Osteoarthritic Pain: Potential for Novel Analgesics. Curr Pain Headache Rep 17(12): 1-9.

Mobasheri A. The future of osteoarthritis therapeutics: emerging biological therapy.
Curr Rheumatol Rep. 2013 Dec;15(12):385. doi: 10.1007/s11926-013-0385-4.
PMID: 24170255 [PubMed - in process] Free PMC Article
Related citations

Swan AL, Mobasheri A, Allaway D, Liddell S, Bacardit J. Application of machine learning to proteomics data: classification and biomarker identification in postgenomics biology.
OMICS. 2013 Dec;17(12):595-610. doi: 10.1089/omi.2013.0017. Epub 2013 Oct 12.
PMID: 24116388 [PubMed - in process] Free PMC Article

Mobasheri A. The future of osteoarthritis therapeutics: targeted pharmacological therapy.
Curr Rheumatol Rep. 2013 Oct;15(10):364. doi: 10.1007/s11926-013-0364-9.
PMID: 24061701 [PubMed - in process] Free PMC Article

Lewis R, May H, Mobasheri A, Barrett-Jolley R. Chondrocyte channel transcriptomics: Do microarray data fit with expression and functional data? Channels (Austin). 2013 Aug 30;7(6). [Epub ahead of print] PMID: 23995703 [PubMed - as supplied by publisher]

Henrotin Y, Chevalier X, Herrero-Beaumont G, McAlindon T, Mobasheri A, Pavelka K, Schon C, Weimans H, Biesalski H. Physiological effects of oral glucosamine on joint health : current status and consensus on future research priorities. BMC res Notes 2013 ; 6 (1) : 115-120.

Henrotin Y, Pesesse L, Lambert C. Targeting the synovial angiogenesis as a novel treatment approach to osteoarthritis. Ther Adv Musculoskelet Dis. 2014 Feb;6(1):20-34. Review

Raine EVA, Reynard LN, van de Larr IMBH, Bertoli-Avella AM, Loughlin J (2014) Identification and analysis of a SMAD3 cis-acting eQTL operating in primary osteoarthritis and in the aortic aneurysms and early-onset OA syndrome. Osteoarthritis Cartilage (in press).

Ratnayake M, Plöger F, Santibanez-Koref M, Loughlin J (2014) Human chondrocytes respond discordantly to the protein encoded by the osteoarthritis susceptibility gene GDF5. PLOS ONE 9:e86590.

 
Submitted manuscript
Santos Franco, S., H. Raveh-Amit, J. Kobolak, M.H. Alqahtani, A. Mobasheri, and A. Dinnyes, The Crossroads Between Cancer Stem Cells and Aging. BMC Genomics, 2014(Special Supplement)
 

 

Oral Presentations at Conferences

Mobasheri A.:
1. Biomarkers of osteoarthritis: translating information from in vitro culture systems to human
patients. The Second International Genomic Medicine Conference in Saudi Arabia - 24-27 November
2013, Jeddah, Kingdom of Saudi Arabia

2. Three Presentations at the 2nd BMJD Congress November 21-24, 2013 Brussels, Belgium
1. Are botanical extracts and herbal medicines promising oral treatments for rheumatic diseases and musculoskeletal complaints?
2. Natural antioxidants for treating inflammatory joint diseases?
3. Applying OMICS techniques to discover new OA biomarkers

3. Mesenchymal Stem Cells and Chondroprogenitors for Cartilage Repair and Regeneration
Oxford Global Stem Cell Congress, 6th – 7th November 2013, London, UK

4. 3-Dimensional Culture Models of Joint Tissues: Applications in Tissue Engineering and Arthritis
Research. Tissue Engineering Today, 5 June 2013, London, UK

5. Biomarkers of osteoarthritis: from in vitro culture systems to animal models and longitudinal
cohort studies. Combined BSAS/AVTRW/RBST/CFER/WPSA Conference, 16/17th April 2013,
Nottingham, UK

COLL2-1NO2: A BIOMARKER FOR EARLY KNEE OSTEOARTHRITIS by Landsmeer MLA, Runhaar J, Henrotin YE, van Middelkoop M, Oei EH, Vroegindeweij D, van der Plas P, Reijman M, van Osch G, Bindels PJE, Bierma-Zeinstra SMA at OARSI 2014, Paris pdf

Reynard L. “Functional analysis of the osteoarthritis susceptibility locus residing at Carbohydrate Sulfuotransferase 11 gene CHST11”. Gordon Research Conference on Cartilage

Biology and Pathology. April 2013 in Les Diablerets, Switzerland

“Osteoarthritis”. Biomedical Research Centre, Frontiers of Aging Research. Public engagement event at Newcastle upon Tyne, October 2013

DECORIN-DEFICIENT MICE ARE LESS PRONE TO DEVELOP OSTEOARTHRITIS AFTER FORCED EXERCISE
DOI: 10.1016/j.joca.2014.02.044) (OARSI 2014) (Tobias Gronau)
BCP CRYSTALS INDUCE HYPERTROPHIC DIFFERENTIATION OF CHONDROCYTES BY ACTIVATING CANONICAL WNT SIGNALING

Regulation of Cartilage Homeostasis and Degeneration by the Small Leucine-rich Proteoglycan Decorin (Talk; Annual Meeting of the German Society for Matrix Biology, March 12-14th 2015, Münster, Germany; Tobias Gronau

Gronau T, Hansen U, Seidler DG, Iozzo RV, Aszódi A, Prein C, Clausen-Schaumann H, Krüger K, Mooren FC, Bertrand J, Pap T, Bruckner P & Dreier R (2015). Forced exercise-induced osteoarthritis is attenuated in mice lacking the small leucine-rich proteoglycan decorin. Ann Rheum Dis 74, A40–A40. (EWRR 2015)
doi: 10.1136/annrheumdis-2015-207259.92

Forced exercise-induced osteoarthritis is attenuated in mice lacking the small leucine-rich proteoglycan decorin (Talk; 35th European Workshop for Rheumatology Research, March 5-7th 2015, Budapest, Hungary) Tobias Gronau

Gronau T, Hubert J, Prein C, Aszódi A, Clausen-Schaumann H, Amling M, Püschel K, Rüther W, Pap T, Bertrand J & Hawellek T (2015). Effects of tissue calcification during osteoarthritis on extracellular matrix and cartilage stiffness. Osteoarthritis and Cartilage 23, Supplement 2, A290. (OARSI 2015)
doi: 10.1016/j.joca.2015.02.527

 

 

Posters

Bertrand, Jessica PhD, Kräft, Tabea ; Nitschke, Yvonne ; Hawellek, Thelonius ;

Hubert, Jan ; Godmann, Lars BSc; Pap, Thomas MD. Cartilage Matrix Remodeling and
Activation Of Canonical Wnt- Signaling Precedes Calcification and OA-Like Changes In
Mice. October 27, 2013. ACR/ARHP MEETING, 2013, San Diego

Bertrand_OARSI_2014 poster (pdf)

Gronau, Tobias, Hansen, Uwe PhD; Seidler, Daniela PhD; Iozzo, Renato MD; Aszodi,
Attila PhD; Prein, Carina ; Clausen-Schaumann, Hauke PhD; Krüger, Karsten PhD;
Mooren, Frank MD; Bertrand, Jessica PhD; Pap, Thomas MD; Bruckner, Peter PhD;
Dreier, Rita PhD. Decorin-Deficiency Alters Cartilage Stiffness and Attenuates The
Development Of Osteoarthritis In Mice. October 27, 2013. ACR/ARHP MEETING,
2013, San Diego

L. Ben-Aderet, E. Reich, E. Merquiol, H. Oppenheimer, D. Fahham, L. Kandel, A. Haze, M. Liebergall J. Steinmeyer, G. Blum, M. Dvir-Ginzberg. Evaluating cathepsin activity and Sirt1 cleavage in experimental osteoarthritis. OARSI April 2014, Paris, France

Ben-Aderet_OARSI_abstract (pdf)

Chandrasekaran, A., L. Neelchen Roesingh, S. Berzsenyi, J. Kobolak, and A. Dinnyes. Small molecule induced neuronal differentiation of hIPS cell lines through NPC derivation. in Fiatal Biotechnológusok Országos Konferenciája (FIBOK 2014). Szeged, Hungary, 7. March 2014.

Lewis, R. and Barrett-Jolley R. (2014) Ion channel modulation of chondrocyte cell volume regulation. FASEB J. 28:1182.1

Lewis_R_abstract  (pdf)

Lewis, R., Paddison, E., Wegg, M. and Barrett-Jolley, R. (2014) Altered ion channel function in an in vitro model of inflammatory arthritis. Osteoarthritis and Cartilage 22:S172-S173

Lewis_R_OARSI-2014-abstract_(pdf)

Dam, E. Is complete segmentation of the OAI knee MRI feasible?. International Workshop in OA Imaging, Iceland, July 2014

Dam_E_IWOAI-Iceland-Poster_(pdf)

Dam_E_IWOAI-abstract (pdf)

Bertrand, Jessica PhD
BCP CRYSTALS INDUCE HYPERTROPHIC DIFFERENTIATION OF CHONDROCYTES BY ACTIVATING CANONICAL WNT SIGNALING
Poster presentation at OARSI 2014, Paris

Gronau, Tobias
Effects of tissue calcification during osteoarthritis on extracellular matrix and cartilage stiffness. (Poster; OARSI 2015)

 

 

Invited Lectures

Dvir-Ginzberg M., Elucidating the Role of SirT1 in Chondrocyte Survival, Gene Expression and Osteoarthritis”.The Epigenetics and Human Disease Hub, Hebrew University of Jerusalem, Israel

Dvir-Ginzberg M., "Elucidating the role of SirT1 in Chondrocyte Survival, Gene Expression and Osteoarthritis". Institute of Molecular Psychiatry, University of Bonn. Germany

Dvir-Ginzberg M., Deciphering the Role of SirT1 in Chondrocyte Survival and Osteoarthritis”, Faculty of Life Sciences, University of Manchester. UK

Loughlin J. “Recent advances in the genetics of OA”. BMJD 2nd World Congress,
Brussels, Belgium. 21st-24th November 2013.

Loughlin J. “Recent advances in the genetics of OA”. American College of Rheumatology, San Diego, USA. 25th-30th October 2013.

Loughlin J. “OA disease mechanisms delineated from the genetic and functional analysis of OA susceptibility”. European Calcified Tissue Society,
Lisbon, Portugal. 18th-21st May 2013.

Loughlin J. “Epigenetic influences in osteoarthritis”. British Society for Rheumatology. Birmingham, UK, 23rd-25th April 2013.

Loughlin J. “Lessons from GWAS of osteoarthritis - where do we go from here?” British Society for Rheumatology. Birmingham, UK, 23rd-25th April 2013.

Reynard L.”Genetic analysis of OA patient cohorts”. International Cartilage Repair Society (ICRS) Summit, Tallinn, Estonia, 2013.