Associations-between-biomarkers-and-skeletal-muscle-function-in-individuals-with-osteoarthritis-a-systematic-review-and-meta-analysis
Full reference: Smith, S.L., Paul, L., Steultjens, M.P.M. et al. Associations between biomarkers and skeletal muscle function in individuals with osteoarthritis: a systematic review and meta-analysis. Arthritis Res Ther 26, 189 (2024). https://doi.org/10.1186/s13075-024-03419-1
Changes in how muscles work, such as weakness, can increase the risk of developing osteoarthritis. Biomarkers are biological molecules in our blood, urine and other bodily fluids, which can indicate or confirm the presence or status of a disease. Biomarkers may be able to detect early signs of muscle problems before noticeable changes are seen in the muscle and may be useful for finding ways to prevent disability in osteoarthritis. Dr Smith, alongside colleagues from the University of Lincoln and Glasgow Caledonian University, searched and reviewed thousands of studies. Of these 24 studies involving over 4,100 people with osteoarthritis identified that Vitamin D may play a role in muscle strength. Many biomarkers were identified, but there was limited information linking biomarkers with muscle function. More research is needed to understand the link between muscle health and osteoarthritis. This could help in detecting muscle weakness early, which could result in preventing osteoarthritis.
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