Pain Centre Versus Arthritis

Knee Pain and related health In the Community (KPIC) cohort

Black and white photo of a person clutching their knee which is glowing red with painThe Knee Pain and related health In the Community (KPIC) was initiated in 2014 as a prospective community-based cohort of 9500 people aged 40 years or over within the East Midlands region (UK). KPIC has, to date, completed 4 waves (0, 1, 3, 6 years) of questionnaire surveys, wave 6 administered within the context of the COVID-19 pandemic. Available data describe:-

  • demographic characteristics
  • knee pain; pain severity, quality and distribution
  • risk factors for knee pain and osteoarthritis (OA) (age, body mass index, knee alignment, nodal OA, index: ring finger length (2D4D ratio)
  • quality of life (SF12)
  • mental health (Hospital Anxiety and Depression Scale).

Clinical assessment/phenotyping of a subsample of 400 wave-0 participants plus 115 incidence knee pain cases was undertaken the first 3 waves. These baseline cases were purposively sampled from the KPIC population to comprise 3 groups: early knee pain (≤3 years), established knee pain or no knee pain. Available data include:-

  • knee radiographs (standing semi-flexed and 300 skyline views)
  • knee ultrasound (synovial effusion, hypertrophy, and power Doppler)
  • quantitative sensory testing (pressure pain detection thresholds and temporal summation)
  • muscle strength (quadriceps, hip abductor, and hand-grip)
  • measured balance
  • gait analysis (GAITrite)
  • blood and urine samples for biomarkers.

 Data enquiries and requests for KPIC should be directed to

View publications involving our KPIC study

Pain Centre Versus Arthritis

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