Kin-Chow Chang qualified as a veterinary surgeon from the University of Bristol. He carried out post-graduate research training at University College London (MSc with Distinction), and at the Royal Veterinary College (RVC), University of London (PhD). He remained at the RVC as a Wellcome Trust Postdoctoral Fellow until 1995 when he joined the Roslin Institute as a Principal Investigator working on the molecular biology and genetics of skeletal muscle. He subsequently took up a senior lectureship at the University of Glasgow veterinary school becoming a Reader in 2006. He joined Nottingham in 2008 as Professor of Veterinary Molecular Medicine with active research programmes on host innate resistance to influenza A viruses and skeletal muscle biology.
Prof. Chang is a Fellow of the Royal College of Veterinary Surgeons, and a Visiting Professor of Liaoning Medical University, China. He has been a member of the Portuguese Animal and Veterinary Sciences Research Committee, Foundation for Science and Technology (FCT) and a member of the scientific committee of the Petplan Charitable Trust. He was a member of the BBSRC Agri-Food Research Committee and convenor of the fourth year undergraduate module of Veterinary Public Health. He is external examiner of the second year BVetMed degree at the Royal Veterinary College. He is in the editorial board of Scientific Reports.
Mammalian host innate resistance to pathogenic influenza virus infection
Influenza A virus infection is a major veterinary disease that affects a wide range of mammalian and avian species, and is a serious zoonotic threat to human public health. We have a major research programme on understanding the mechanisms of host innate disease resistance to influenza infections. One of our strategic approaches is to compare host response to virulent influenza virus infection (such as avian H5N1 virus) between resistant (e.g. pig, duck and bat) and susceptible (human and chicken) species to identify targets for the development of intervention therapy to reduce disease severity. Collaborators include colleagues from the Animal and Plant Health Agency, Weybridge (Prof. Ian Brown) and China Agricultural University (Prof. Jinhua Liu).
Molecular basis of phenotype determination in skeletal muscle of target and model animal species
We have a major research programme on understanding the basic and strategic biology of skeletal muscle development and growth in model and farm species. We conduct fundamental research of biomedical and agricultural importance in relation to muscle growth (hypertrophy and atrophy) and muscle as a major organ of host innate immunity. The aim is to identify host targets for intervention to improve the physical characteristics of muscle and its innate immunity during growth or at old age.
GAO,W., ZU,Z., SONG,J., WANG,X., WANG,C., LIU,L., TONG,O., WANG,M., SUN,H., SUN,Y., LIU,J., CHANG,K.C. and PU,J., 2019. Prevailing I292V PB2 mutation in avian influenza H9N2 virus increases viral polymerase function and attenuates IFN-β induction in human cells. J. Gen. Virol. 100(9), 1273-1281 PU,J., SUN,H., QU,Y., WANG,C., GAO,W., ZHU,J., SUN,Y., BI,Y., CHANG,K.C., CUI,J. and LIU,J., 2017. M-gene reassortment in H9N2 influenza virus promotes early infection and replication: contribution to rising virus prevalence in chickens in China J.Virol. 91(8), e02055-16
ZHANG,X., XU,G., WANG,C., JIANG,M., GAO,W., WANG,M., SUN,H., SUN,Y., CHANG,K.C., LIU,J. and PU,J., 2017. Enhanced pathogenicity and neurotropism of mouse-adapted H10N7 influenza virus are mediated by novel PB2 and NA mutations J.Gen.Virol. 98, 1185-1195