School of Veterinary Medicine and Science

People

Image of Kin-Chow Chang

Kin-Chow Chang

Professor of Veterinary Molecular Medicine, Faculty of Medicine & Health Sciences

Contact

  • workRoom A14a Veterinary Academic Building
    Sutton Bonington Campus
    Sutton Bonington
    Leicestershire
    LE12 5RD
    UK
  • work0115 951 6491

Biography

Kin-Chow Chang qualified as a veterinary surgeon from the University of Bristol. He undertook post-graduate research training at University College London (MSc with Distinction), and at the Royal Veterinary College (RVC), University of London (PhD). He was awarded a 5-year Wellcome Trust Postdoctoral Fellowship based at the RVC after which he joined the Roslin Institute as a Principal Investigator. He subsequently took up a senior lectureship at the University of Glasgow becoming a Reader in 2006. He joined the University of Nottingham in 2008 as Professor of Veterinary Molecular Medicine. His main research focus is on host innate resistance and antivirals against respiratory viruses (SARS-CoV-2, influenza and respiratory syncytial virus), with long-standing active involvement in skeletal muscle biology.

Expertise Summary

Prof. Chang is a Fellow of the Royal College of Veterinary Surgeons, and a Visiting Professor of Liaoning Medical University, China. He had been a long serving member of the Portuguese Animal and Veterinary Sciences Research Committee, Foundation for Science and Technology (FCT) and is a member of the scientific committee of the Petplan Charitable Trust. He was a member of the BBSRC Agri-Food Research Committee and convenor of the fourth year undergraduate module of Veterinary Public Health. He was an external examiner of the second year BVetMed degree at the Royal Veterinary College and in the editorial board of Scientific Reports.

Research Summary

Mammalian host innate resistance to respiratory viruses

Coronavirus (in particular pandemic SARS-CoV-2), influenza A virus and respiratory syncytial virus are major respiratory pathogens that can inflict widespread and serious morbidity and mortality in human and animal hosts. We seek to understand the mechanisms of host innate disease resistance to such viral infections. One strategic approach we have adopted is to compare host response to virulent influenza virus infection (such as highly pathogenic avian H5N1 virus) between resistant (e.g. pig and duck) and susceptible (human and chicken) species to identify host targets for the development of antivirals to tackle active infection of different viruses.

Molecular basis of phenotype determination in skeletal muscle

We have a track record on skeletal muscle research in understanding the molecular basis of fibre type determination, muscle hypertrophy, and muscle as a major innate immune organ.

Selected Publications

School of Veterinary Medicine and Science

University of Nottingham
Sutton Bonington Campus
Leicestershire, LE12 5RD

telephone: +44 (0)115 951 6116
fax: +44 (0)115 951 6415
email: veterinary-enquiries@nottingham.ac.uk