Professor of Veterinary Molecular Medicine, Faculty of Medicine & Health Sciences
Kin-Chow Chang qualified as a veterinary surgeon from the University of Bristol. He undertook post-graduate research training at University College London (MSc with Distinction), and at the Royal Veterinary College (RVC), University of London (PhD). He was awarded a 5-year Wellcome Trust Postdoctoral Fellowship based at the RVC after which he joined the Roslin Institute as a Principal Investigator. He subsequently took up a senior lectureship at the University of Glasgow and became a Reader. He is a Fellow of the Royal College of Veterinary Surgeons (FRCVS). He later joined the University of Nottingham in 2008 as Professor of Veterinary Molecular Medicine. His main research focus is on host innate resistance and antivirals against respiratory viruses (SARS-CoV-2, influenza and respiratory syncytial virus), with long-standing research involvement in skeletal muscle biology.
Mammalian host innate resistance to respiratory viruses
Coronavirus (in particular pandemic SARS-CoV-2), influenza A virus and respiratory syncytial virus are major respiratory pathogens that can inflict widespread and serious morbidity and mortality in human and animal hosts. We seek to understand the mechanisms of host innate disease resistance to such viral infections. One strategic approach we have adopted is to compare host response to virulent influenza virus infection (such as highly pathogenic avian H5N1 virus) between resistant (e.g. pig and duck) and susceptible (human and chicken) species to identify host targets for the development of antivirals to tackle active infection of different viruses.
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