Kin-Chow Chang qualified as a veterinary surgeon from the University of Bristol. He undertook post-graduate research training at University College London (MSc with Distinction), and at the Royal Veterinary College (RVC), University of London (PhD). He was awarded a 5-year Wellcome Trust Postdoctoral Fellowship based at the RVC after which he joined the Roslin Institute as a Principal Investigator. He subsequently took up a senior lectureship at the University of Glasgow becoming a Reader in 2006. He joined the University of Nottingham in 2008 as Professor of Veterinary Molecular Medicine. His main research focus is on host innate resistance and antivirals against respiratory viruses (SARS-CoV-2, influenza and respiratory syncytial virus), with long-standing active involvement in skeletal muscle biology.
Prof. Chang is a Fellow of the Royal College of Veterinary Surgeons, and a Visiting Professor of Liaoning Medical University, China. He had been a long serving member of the Portuguese Animal and Veterinary Sciences Research Committee, Foundation for Science and Technology (FCT) and is a member of the scientific committee of the Petplan Charitable Trust. He was a member of the BBSRC Agri-Food Research Committee and convenor of the fourth year undergraduate module of Veterinary Public Health. He was an external examiner of the second year BVetMed degree at the Royal Veterinary College and in the editorial board of Scientific Reports.
Mammalian host innate resistance to respiratory viruses
Coronavirus (in particular pandemic SARS-CoV-2), influenza A virus and respiratory syncytial virus are major respiratory pathogens that can inflict widespread and serious morbidity and mortality in human and animal hosts. We seek to understand the mechanisms of host innate disease resistance to such viral infections. One strategic approach we have adopted is to compare host response to virulent influenza virus infection (such as highly pathogenic avian H5N1 virus) between resistant (e.g. pig and duck) and susceptible (human and chicken) species to identify host targets for the development of antivirals to tackle active infection of different viruses.
Molecular basis of phenotype determination in skeletal muscle
We have a track record on skeletal muscle research in understanding the molecular basis of fibre type determination, muscle hypertrophy, and muscle as a major innate immune organ.
SARAH AL-BELTAGI, LEAH V. GOULDING, DANIEL K.E. CHANG, KENNETH H. MELLITS, CHRISTOPHER J. HAYES, PAVEL GERSHKOVICH, CHRISTOPHER M. COLEMAN and KIN-CHOW CHANG, 2021. Emergent SARS-CoV-2 variants: comparative replication dynamics and high sensitivity to thapsigargin Virulence. 12(1), 2946-2956 JIANG, ZHIMIN, WEI, FANHUA, ZHANG, YUYING, WANG, TONG, GAO, WEIHUA, YU, SHUFANG, SUN, HONGLEI, PU, JUAN, SUN, YIPENG, WANG, MINGYANG, TONG, QI, GAO, CHENGJIANG, CHANG, KIN-CHOW and LIU, JINHUA, 2021. IFI16 directly senses viral RNA and enhances RIG-I transcription and activation to restrict influenza virus infection. Nature Microbiology. 6, 932-945 AL-BELTAGI, SARAH, PREDA, CRISTIAN ALEXANDRU, GOULDING, LEAH V., JAMES, JOE, PU, JUAN, SKINNER, PAUL, JIANG, ZHIMIN, WANG, BELINDA LEI, YANG, JIAYUN, BANYARD, ASHLEY C., MELLITS, KENNETH H., GERSHKOVICH, PAVEL, HAYES, CHRISTOPHER J., NGUYEN-VAN-TAM, JONATHAN, BROWN, IAN H., LIU, JINHUA and CHANG, KIN-CHOW, 2021. Thapsigargin Is a Broad-Spectrum Inhibitor of Major Human Respiratory Viruses: Coronavirus, Respiratory Syncytial Virus and Influenza A Virus Viruses. 13, 234
SUN, HONGLEI, XIAO, YIHONG, LIU, JIYU, WANG, DAYAN, LI, FANGTAO, WANG, CHENXI, LI, CHONG, ZHU, JUNDA, SONG, JINGWEI, SUN, HAORAN, JIANG, ZHIMIN, LIU, LITAO, ZHANG, XIN, WEI, KAI, HOU, DONGJUN, PU, JUAN, SUN, YIPENG, TONG, QI, BI, YUHAI, CHANG, KIN-CHOW, LIU, SIDANG, GAO, GEORGE F. and LIU, JINHUA, 2020. Prevalent Eurasian avian-like H1N1 swine influenza virus with 2009 pandemic viral genes facilitating human infection Proceedings of the National Academy of Sciences USA. 117(29), 17204-17210