Biomaterials Discovery

Publications

Here is a list of the publications that our team of academics and researchers have authored, or contributed to, on the topic of biomaterials discovery.

2025

  • Bioinstructive Polymer Fibre Mats to Reduce Bacterial Pathogen Colonisation. In preparation.
  • Wound-healing biodegradable microparticles: an in vitro investigation. Biomaterials Science.
  • Feasibility of diffuse Raman spectroscopy to detect in-vivo molecular changes in the tissue induced by subcutaneous implants. Biomedical Optics Express.
  • Helix 1.0: An Open-Source Framework for Reproducible and Interpretable Machine Learning on Tabular Scientific Data. arXiv.
  • Combinatorial discovery of micro-topographical landscapes that resist biofilm formation through quorum sensing-mediated auto-lubrication. Nature Communications.
  • High-Throughput Analysis of Protein Adsorption to a Large Library of Polymers Using Liquid Extraction Surface Analysis–Tandem Mass Spectrometry (LESA-MS/MS). Analytical Chemistry.
  • Study on molecular orientation and stratification in RNA-lipid nanoparticles by cryogenic orbitrap secondary ion mass spectrometry. Communications Chemistry.
  • Molecular biointerface characterisation for an implanted medical device using cryogenic orbitrap secondary ion mass spectrometry (Cryo-OrbiSIMS). bioRxiv.
  • Screening of modular supramolecular star polymers for 3D printing of biomedical devices. Materials Today Communications.
  • Modulation of the biological response to surfaces through the controlled deposition of 3D polymeric surfactants. Journal of Materials Chemistry B.
  • Development of C. albican Anti-attachment Inkjet 3D Printing Ink, via High Throughput Screening. International Conference on Computational & Experimental Engineering and Sciences.

2024

  • Fungal Attachment-Resistant Polymers for the Additive Manufacture of Medical Devices. ACS Applied Materials & Interfaces.
  • Discovery and computational modeling of adsorbent polymers that effectively immobilize SARS-CoV-2, with potential practical applications. Cell Reports Physical Science.
  • Computer Vision for Substrate Detection in High‐Throughput Biomaterial Screens Using Bright‐Field Microscopy. Advanced Intelligent Systems.
  • Merging Modular Molecular Design with High Throughput Screening of Cell Adhesion on Antimicrobial Supramolecular Biomaterials. Macromolecular Rapid Communications.
  • Spatially resolved molecular analysis of host response to medical device implantation using the 3D OrbiSIMS highlights a critical role for lipids. Advanced Science.
  • Polymer-coated urinary catheter reduces biofilm formation and biomineralization: a first-in-man, prospective pilot study. JU Open Plus.

2023 Q2-4 (Materials for Medical Devices Large Grant start)

  • Toward comprehensive analysis of the 3D chemistry of Pseudomonas aeruginosa biofilms. Analytical Chemistry.
  • Optimization of diffuse Raman spectroscopy for in-vivo quantification of foreign body response in a small animal model. Biomedical Optics Express.
  • Antibacterial evaluation of natural oridonin and its chemically synthesised derivatives. Planta Medica.
  • A potential alternative to fungicides using actives-free (meth) acrylate polymers for protection of wheat crops from fungal attachment and infection. Green Chemistry.
  • Label-free Chemical Characterization of Polarized Immune Cells in vitro and Host Response to Implanted Bio-instructive Polymers in vivo Using 3D OrbiSIMS. Bio-protocol.
  • Identification of Pseudomonas aeruginosa exopolysaccharide Psl in biofilms using 3D OrbiSIMS. Biointerphases.
  • Untargeted Metabolomic Characterization of Glioblastoma Intra-Tumor Heterogeneity Using OrbiSIMS. Analytical Chemistry.
  • Surface-sampling mass spectrometry to study proteins and protein complexes. Essays in Biochemistry.
  • Probing Interkingdom Signaling Molecules via Liquid Extraction Surface Analysis–Mass Spectrometry. Analytical Chemistry.
  • Linear Binary Classifier to Predict Bacterial Biofilm Formation on Polyacrylates. Applied Materials & Interfaces.
  • Exploring the Relationship between Polymer Surface Chemistry and Bacterial Attachment Using ToF-SIMS and Self-Organizing maps. Advanced Materials Interfaces.


2023 Q1

  • Discovery of a polymer resistant to bacterial biofilm, swarming, and encrustation. Science Advances.
  • Innate immune cell instruction using micron-scale 3D objects of varied architecture and polymer chemistry: The ChemoArchiChip. Matter.
  • Biomaterials discovery: experimental and computational approaches. Tissue Engineering.
  • Identifying new biomarkers of aggressive Group 3 and SHH medulloblastoma using 3D hydrogel models, single cell RNA sequencing and 3D OrbiSIMS imaging. Acta Neuropathologia Communications.
  • Predictive Molecular Design and Structure–Property Validation of Novel Terpene-Based, Sustainably Sourced Bacterial Biofilm-Resistant Materials. Biomacromolecules.

2022

  • Microparticles Decorated with Cell‐Instructive Surface Chemistries Actively Promote Wound Healing. Advanced Materials.
  • Feature importance in machine learning models: A fuzzy information fusion approach. Neurocomputing.
  • Evaluation of the relative potential for contact and doffing transmission of SARS-CoV-2 by a range of personal protective equipment materials. Scientific Reports.
  • Single-cell metabolic profiling of macrophages using 3D OrbiSIMS: Correlations with phenotype. Analytical Chemistry.
  • A multifaceted ferrocene interlayer for highly stable and efficient lithium doped spiro‐OMeTAD‐based perovskite solar cells. Advanced Energy Materials.
  • Micro topographical instruction of bacterial attachment, biofilm formation and in vivo host response. bioRxiv.
  • Immune-instructive materials as new tools for immunotherapy. Current Opinion in Biotechnology.
  • Elucidating the molecular landscape of the stratum corneum. Proceedings of the National Academy of Sciences.
  • Molecular formula prediction for chemical filtering of 3D OrbiSIMS Datasets. Analytical Chemistry.
  • A new particle mounting method for surface analysis. Surface Interface and Analysis.

  • Efficacy of antimicrobial and anti-viral coated air filters to prevent the spread of airborne pathogens. Scientific Reports.

  • Developing Novel Biointerfaces: Using Chlorhexidine Surface Attachment as a Method for Creating Anti‐Fungal Surfaces. Global Challenges.

  • Ink-jet 3D printing as a strategy for developing bespoke non-eluting biofilm resistant medical devices. Biomaterials.

  • Quantifiable correlation of ToF‐SIMS and XPS data from polymer surfaces with controlled amino acid and peptide content. Surface and Interface Analysis.

  • Polymer-directed inhibition of reversible to irreversible attachment prevents Pseudomonas aeruginosa biofilm formation. bioRxiv.
  • The Galapagos Chip Platform for High‐Throughput Screening of Cell Adhesive Chemical Micropatterns. Small.

2021

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2015

2014

2013

2012

Next Generation Biomaterials Discovery

Advanced Materials and Healthcare Technologies, School of Pharmacy, The University of Nottingham
University Park
Nottingham, NG7 2RD


telephone: +44 (0) 115 846 6246
email: BiomaterialsDiscovery@nottingham.ac.uk